First-in-human trial of blood–brain barrier opening in amyotrophic lateral sclerosis using MR-guided focused ultrasound

MR-focused ultrasound can be used to transiently open the blood-brain barrier (BBB). Here, the authors report the results of a first-in-human trial on four patients with amyotrophic lateral sclerosis (ALS), showing that the procedure reversibly permeabilised the BBB in the motor cortex without compl...

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Autores principales:	Agessandro Abrahao, Ying Meng, Maheleth Llinas, Yuexi Huang, Clement Hamani, Todd Mainprize, Isabelle Aubert, Chinthaka Heyn, Sandra E. Black, Kullervo Hynynen, Nir Lipsman, Lorne Zinman
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/39152bb20d4547b38efa39b5f3872500
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spelling	oai:doaj.org-article:39152bb20d4547b38efa39b5f38725002021-12-02T14:39:16ZFirst-in-human trial of blood–brain barrier opening in amyotrophic lateral sclerosis using MR-guided focused ultrasound10.1038/s41467-019-12426-92041-1723https://doaj.org/article/39152bb20d4547b38efa39b5f38725002019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12426-9https://doaj.org/toc/2041-1723MR-focused ultrasound can be used to transiently open the blood-brain barrier (BBB). Here, the authors report the results of a first-in-human trial on four patients with amyotrophic lateral sclerosis (ALS), showing that the procedure reversibly permeabilised the BBB in the motor cortex without complications, and suggest that the procedure could in the future be used to increase drug delivery in ALS patients.Agessandro AbrahaoYing MengMaheleth LlinasYuexi HuangClement HamaniTodd MainprizeIsabelle AubertChinthaka HeynSandra E. BlackKullervo HynynenNir LipsmanLorne ZinmanNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Agessandro Abrahao Ying Meng Maheleth Llinas Yuexi Huang Clement Hamani Todd Mainprize Isabelle Aubert Chinthaka Heyn Sandra E. Black Kullervo Hynynen Nir Lipsman Lorne Zinman First-in-human trial of blood–brain barrier opening in amyotrophic lateral sclerosis using MR-guided focused ultrasound
description	MR-focused ultrasound can be used to transiently open the blood-brain barrier (BBB). Here, the authors report the results of a first-in-human trial on four patients with amyotrophic lateral sclerosis (ALS), showing that the procedure reversibly permeabilised the BBB in the motor cortex without complications, and suggest that the procedure could in the future be used to increase drug delivery in ALS patients.
format	article
author	Agessandro Abrahao Ying Meng Maheleth Llinas Yuexi Huang Clement Hamani Todd Mainprize Isabelle Aubert Chinthaka Heyn Sandra E. Black Kullervo Hynynen Nir Lipsman Lorne Zinman
author_facet	Agessandro Abrahao Ying Meng Maheleth Llinas Yuexi Huang Clement Hamani Todd Mainprize Isabelle Aubert Chinthaka Heyn Sandra E. Black Kullervo Hynynen Nir Lipsman Lorne Zinman
author_sort	Agessandro Abrahao
title	First-in-human trial of blood–brain barrier opening in amyotrophic lateral sclerosis using MR-guided focused ultrasound
title_short	First-in-human trial of blood–brain barrier opening in amyotrophic lateral sclerosis using MR-guided focused ultrasound
title_full	First-in-human trial of blood–brain barrier opening in amyotrophic lateral sclerosis using MR-guided focused ultrasound
title_fullStr	First-in-human trial of blood–brain barrier opening in amyotrophic lateral sclerosis using MR-guided focused ultrasound
title_full_unstemmed	First-in-human trial of blood–brain barrier opening in amyotrophic lateral sclerosis using MR-guided focused ultrasound
title_sort	first-in-human trial of blood–brain barrier opening in amyotrophic lateral sclerosis using mr-guided focused ultrasound
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/39152bb20d4547b38efa39b5f3872500
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First-in-human trial of blood–brain barrier opening in amyotrophic lateral sclerosis using MR-guided focused ultrasound

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