Changes in DXA-derived lean mass and MRI-derived cross-sectional area of the thigh are modestly associated

Abstract Dual-energy X-ray absorptiometry (DXA) derived measures of lean mass demonstrate strong associations with magnetic resonance imaging (MRI) derived measures of muscle volume (MV) in cross-sectional studies, however, few studies have compared changes in response to an intervention. The purpos...

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Autores principales:	Dallin Tavoian, Kwasi Ampomah, Shinichi Amano, Timothy D. Law, Brian C. Clark
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/391630fc1e5b4ec8b94eab76fc564dd3
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spelling	oai:doaj.org-article:391630fc1e5b4ec8b94eab76fc564dd32021-12-02T15:09:24ZChanges in DXA-derived lean mass and MRI-derived cross-sectional area of the thigh are modestly associated10.1038/s41598-019-46428-w2045-2322https://doaj.org/article/391630fc1e5b4ec8b94eab76fc564dd32019-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-46428-whttps://doaj.org/toc/2045-2322Abstract Dual-energy X-ray absorptiometry (DXA) derived measures of lean mass demonstrate strong associations with magnetic resonance imaging (MRI) derived measures of muscle volume (MV) in cross-sectional studies, however, few studies have compared changes in response to an intervention. The purpose of this study was to determine the accuracy of DXA at detecting changes in lean mass, using MRI-derived MV as a reference standard. 10 male and 16 female subjects (29.2 ± 9.5 years) underwent DXA and MRI scans before and after a 10-week resistance training intervention. DXA thigh lean mass was compared to MRI mid-thigh MV, and percent change in size was compared between MRI and DXA. There was a strong correlation between measures cross-sectionally (r = 0.89) in agreement with previous investigations. However, there was a modest correlation of percentage change over time between methods (r = 0.49). Bland-Altman plots revealed that the amount of random error increased as the magnitude of the change from baseline increased. DXA measures of change in lean mass were modestly associated with MRI measures of change in MV. While there are several advantages to using DXA for the measurement of lean mass, the inability to accurately detect changes over time calls into question its use in clinical trials.Dallin TavoianKwasi AmpomahShinichi AmanoTimothy D. LawBrian C. ClarkNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-9 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Dallin Tavoian Kwasi Ampomah Shinichi Amano Timothy D. Law Brian C. Clark Changes in DXA-derived lean mass and MRI-derived cross-sectional area of the thigh are modestly associated
description	Abstract Dual-energy X-ray absorptiometry (DXA) derived measures of lean mass demonstrate strong associations with magnetic resonance imaging (MRI) derived measures of muscle volume (MV) in cross-sectional studies, however, few studies have compared changes in response to an intervention. The purpose of this study was to determine the accuracy of DXA at detecting changes in lean mass, using MRI-derived MV as a reference standard. 10 male and 16 female subjects (29.2 ± 9.5 years) underwent DXA and MRI scans before and after a 10-week resistance training intervention. DXA thigh lean mass was compared to MRI mid-thigh MV, and percent change in size was compared between MRI and DXA. There was a strong correlation between measures cross-sectionally (r = 0.89) in agreement with previous investigations. However, there was a modest correlation of percentage change over time between methods (r = 0.49). Bland-Altman plots revealed that the amount of random error increased as the magnitude of the change from baseline increased. DXA measures of change in lean mass were modestly associated with MRI measures of change in MV. While there are several advantages to using DXA for the measurement of lean mass, the inability to accurately detect changes over time calls into question its use in clinical trials.
format	article
author	Dallin Tavoian Kwasi Ampomah Shinichi Amano Timothy D. Law Brian C. Clark
author_facet	Dallin Tavoian Kwasi Ampomah Shinichi Amano Timothy D. Law Brian C. Clark
author_sort	Dallin Tavoian
title	Changes in DXA-derived lean mass and MRI-derived cross-sectional area of the thigh are modestly associated
title_short	Changes in DXA-derived lean mass and MRI-derived cross-sectional area of the thigh are modestly associated
title_full	Changes in DXA-derived lean mass and MRI-derived cross-sectional area of the thigh are modestly associated
title_fullStr	Changes in DXA-derived lean mass and MRI-derived cross-sectional area of the thigh are modestly associated
title_full_unstemmed	Changes in DXA-derived lean mass and MRI-derived cross-sectional area of the thigh are modestly associated
title_sort	changes in dxa-derived lean mass and mri-derived cross-sectional area of the thigh are modestly associated
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/391630fc1e5b4ec8b94eab76fc564dd3
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Changes in DXA-derived lean mass and MRI-derived cross-sectional area of the thigh are modestly associated

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