Cell-Free Biomimetic Mineralization Strategies to Regenerate the Enamel Microstructure

The distinct architecture of native enamel gives it its exquisite appearance and excellent intrinsic-extrinsic fracture toughening properties. However, damage to the enamel is irreversible. At present, the clinical treatment for enamel lesion is an invasive method; besides, its limitations, caused b...

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Autores principales:	Yu Yuan Zhang, Quan Li Li, Hai Ming Wong
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	enamel-inspired mineralization enamel-like structure biomineralization biomimetic mineralization Crystallography QD901-999
Acceso en línea:	https://doaj.org/article/391662df822f4a9682a78aa6df237a35
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id	oai:doaj.org-article:391662df822f4a9682a78aa6df237a35
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spelling	oai:doaj.org-article:391662df822f4a9682a78aa6df237a352021-11-25T17:19:11ZCell-Free Biomimetic Mineralization Strategies to Regenerate the Enamel Microstructure10.3390/cryst111113852073-4352https://doaj.org/article/391662df822f4a9682a78aa6df237a352021-11-01T00:00:00Zhttps://www.mdpi.com/2073-4352/11/11/1385https://doaj.org/toc/2073-4352The distinct architecture of native enamel gives it its exquisite appearance and excellent intrinsic-extrinsic fracture toughening properties. However, damage to the enamel is irreversible. At present, the clinical treatment for enamel lesion is an invasive method; besides, its limitations, caused by the chemical and physical difference between restorative materials and dental hard tissue, makes the restorative effects far from ideal. With more investigations on the mechanism of amelogenesis, biomimetic mineralization techniques for enamel regeneration have been well developed, which hold great promise as a non-invasive strategy for enamel restoration. This review disclosed the chemical and physical mechanism of amelogenesis; meanwhile, it overviewed and summarized studies involving the regeneration of enamel microstructure in cell-free biomineralization approaches, which could bring new prospects for resolving the challenges in enamel regeneration.Yu Yuan ZhangQuan Li LiHai Ming WongMDPI AGarticleenamel-inspired mineralizationenamel-like structurebiomineralizationbiomimetic mineralizationCrystallographyQD901-999ENCrystals, Vol 11, Iss 1385, p 1385 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	enamel-inspired mineralization enamel-like structure biomineralization biomimetic mineralization Crystallography QD901-999
spellingShingle	enamel-inspired mineralization enamel-like structure biomineralization biomimetic mineralization Crystallography QD901-999 Yu Yuan Zhang Quan Li Li Hai Ming Wong Cell-Free Biomimetic Mineralization Strategies to Regenerate the Enamel Microstructure
description	The distinct architecture of native enamel gives it its exquisite appearance and excellent intrinsic-extrinsic fracture toughening properties. However, damage to the enamel is irreversible. At present, the clinical treatment for enamel lesion is an invasive method; besides, its limitations, caused by the chemical and physical difference between restorative materials and dental hard tissue, makes the restorative effects far from ideal. With more investigations on the mechanism of amelogenesis, biomimetic mineralization techniques for enamel regeneration have been well developed, which hold great promise as a non-invasive strategy for enamel restoration. This review disclosed the chemical and physical mechanism of amelogenesis; meanwhile, it overviewed and summarized studies involving the regeneration of enamel microstructure in cell-free biomineralization approaches, which could bring new prospects for resolving the challenges in enamel regeneration.
format	article
author	Yu Yuan Zhang Quan Li Li Hai Ming Wong
author_facet	Yu Yuan Zhang Quan Li Li Hai Ming Wong
author_sort	Yu Yuan Zhang
title	Cell-Free Biomimetic Mineralization Strategies to Regenerate the Enamel Microstructure
title_short	Cell-Free Biomimetic Mineralization Strategies to Regenerate the Enamel Microstructure
title_full	Cell-Free Biomimetic Mineralization Strategies to Regenerate the Enamel Microstructure
title_fullStr	Cell-Free Biomimetic Mineralization Strategies to Regenerate the Enamel Microstructure
title_full_unstemmed	Cell-Free Biomimetic Mineralization Strategies to Regenerate the Enamel Microstructure
title_sort	cell-free biomimetic mineralization strategies to regenerate the enamel microstructure
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/391662df822f4a9682a78aa6df237a35
work_keys_str_mv	AT yuyuanzhang cellfreebiomimeticmineralizationstrategiestoregeneratetheenamelmicrostructure AT quanlili cellfreebiomimeticmineralizationstrategiestoregeneratetheenamelmicrostructure AT haimingwong cellfreebiomimeticmineralizationstrategiestoregeneratetheenamelmicrostructure
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Cell-Free Biomimetic Mineralization Strategies to Regenerate the Enamel Microstructure

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