The role of topical vitamin A in promoting healing in surface refractive procedures: a prospective randomized controlled study

The role of topical vitamin A in promoting healing in surface refractive procedures: a prospective randomized controlled study

Elias Chelala,1 Ali Dirani,1 Ali Fadlallah,1 Sharbel Fahd21Saint Joseph University, Faculty of Medicine, Beirut, Lebanon; 2Ophthalmic Consultant of Beirut, Chairman Ophthalmology, Lebanese American University, Beirut, LebanonAim: To evaluate the effect of topical vitamin A supplementation on corneal...

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Autores principales: Chelala E, Dirani A, Fadlallah A, Fahd S
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2013
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Ophthalmology
RE1-994
Acceso en línea:https://doaj.org/article/3917045d0ee54c7bb1d9565bb73b3683
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spelling oai:doaj.org-article:3917045d0ee54c7bb1d9565bb73b36832021-12-02T02:58:52ZThe role of topical vitamin A in promoting healing in surface refractive procedures: a prospective randomized controlled study1177-54671177-5483https://doaj.org/article/3917045d0ee54c7bb1d9565bb73b36832013-09-01T00:00:00Zhttp://www.dovepress.com/the-role-of-topical-vitamin-a-in-promoting-healing-in-surface-refracti-a14453https://doaj.org/toc/1177-5467https://doaj.org/toc/1177-5483Elias Chelala,1 Ali Dirani,1 Ali Fadlallah,1 Sharbel Fahd21Saint Joseph University, Faculty of Medicine, Beirut, Lebanon; 2Ophthalmic Consultant of Beirut, Chairman Ophthalmology, Lebanese American University, Beirut, LebanonAim: To evaluate the effect of topical vitamin A supplementation on corneal re-epithelialization time, postoperative pain, visual acuity, and haze following photorefractive keratectomy (PRK).Patients and methods: This prospective study included 32 patients. For each patient, one eye was randomized to the vitamin A group and the fellow eye to the non-vitamin A group (control group). Eyes in the vitamin A group received perioperative topical vitamin A (retinol palmitate, 250 IU/g VitAPOS eye ointment [AFT Pharmaceuticals Pty, Ltd, Sydney, NSW, Australia]) in addition to the classic treatment for PRK. Clinical outcomes were evaluated up to 3 months after PRK.Results: There was no difference in the mean time to complete healing between the vitamin A group and the control group (3.36 ± 0.6 days in the control group; 3.42 ± 0.7 days in the vitamin A group; P = 0.854). Mean postoperative pain at the 48-hour visit was 4.35 ± 1.42 over 10 in the control group, and 4.42 ± 1.37 over 10 in the vitamin A group, with no difference between the two groups (P = 0.589). Subepithelial haze evaluated at 3 months postoperatively did not differ between the two groups (P = 0.960). Also, visual and refractive outcomes were not different between the two groups 3 months postoperatively.Conclusion: Topical vitamin A supplementation did not affect re-epithelialization time, postoperative pain, corneal haze formation, or visual outcomes after PRK.Keywords: photorefractive keratectomy, topical vitamin A, corneal re-epithelializationChelala EDirani AFadlallah AFahd SDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2013, Iss default, Pp 1913-1918 (2013)
institution DOAJ
collection DOAJ
language EN
topic Ophthalmology
RE1-994
spellingShingle Ophthalmology
RE1-994
Chelala E
Dirani A
Fadlallah A
Fahd S
The role of topical vitamin A in promoting healing in surface refractive procedures: a prospective randomized controlled study
description Elias Chelala,1 Ali Dirani,1 Ali Fadlallah,1 Sharbel Fahd21Saint Joseph University, Faculty of Medicine, Beirut, Lebanon; 2Ophthalmic Consultant of Beirut, Chairman Ophthalmology, Lebanese American University, Beirut, LebanonAim: To evaluate the effect of topical vitamin A supplementation on corneal re-epithelialization time, postoperative pain, visual acuity, and haze following photorefractive keratectomy (PRK).Patients and methods: This prospective study included 32 patients. For each patient, one eye was randomized to the vitamin A group and the fellow eye to the non-vitamin A group (control group). Eyes in the vitamin A group received perioperative topical vitamin A (retinol palmitate, 250 IU/g VitAPOS eye ointment [AFT Pharmaceuticals Pty, Ltd, Sydney, NSW, Australia]) in addition to the classic treatment for PRK. Clinical outcomes were evaluated up to 3 months after PRK.Results: There was no difference in the mean time to complete healing between the vitamin A group and the control group (3.36 ± 0.6 days in the control group; 3.42 ± 0.7 days in the vitamin A group; P = 0.854). Mean postoperative pain at the 48-hour visit was 4.35 ± 1.42 over 10 in the control group, and 4.42 ± 1.37 over 10 in the vitamin A group, with no difference between the two groups (P = 0.589). Subepithelial haze evaluated at 3 months postoperatively did not differ between the two groups (P = 0.960). Also, visual and refractive outcomes were not different between the two groups 3 months postoperatively.Conclusion: Topical vitamin A supplementation did not affect re-epithelialization time, postoperative pain, corneal haze formation, or visual outcomes after PRK.Keywords: photorefractive keratectomy, topical vitamin A, corneal re-epithelialization
format article
author Chelala E
Dirani A
Fadlallah A
Fahd S
author_facet Chelala E
Dirani A
Fadlallah A
Fahd S
author_sort Chelala E
title The role of topical vitamin A in promoting healing in surface refractive procedures: a prospective randomized controlled study
title_short The role of topical vitamin A in promoting healing in surface refractive procedures: a prospective randomized controlled study
title_full The role of topical vitamin A in promoting healing in surface refractive procedures: a prospective randomized controlled study
title_fullStr The role of topical vitamin A in promoting healing in surface refractive procedures: a prospective randomized controlled study
title_full_unstemmed The role of topical vitamin A in promoting healing in surface refractive procedures: a prospective randomized controlled study
title_sort role of topical vitamin a in promoting healing in surface refractive procedures: a prospective randomized controlled study
publisher Dove Medical Press
publishDate 2013
url https://doaj.org/article/3917045d0ee54c7bb1d9565bb73b3683
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