A RAB35-p85/PI3K axis controls oscillatory apical protrusions required for efficient chemotactic migration

A RAB35-p85/PI3K axis controls oscillatory apical protrusions required for efficient chemotactic migration

Circular dorsal ruffles (CDRs) are apical actin enriched structures involved in the interpretation of growth factor gradients during cell migration. Here, the authors find that a RAB35/PI3K axis is necessary and sufficient for the formation and stabilization of polarized CDRs and persistent directio...

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Autores principales: Salvatore Corallino, Chiara Malinverno, Beate Neumann, Christian Tischer, Andrea Palamidessi, Emanuela Frittoli, Magdalini Panagiotakopoulou, Andrea Disanza, Gema Malet-Engra, Paulina Nastaly, Camilla Galli, Chiara Luise, Giovanni Bertalot, Salvatore Pece, Pier Paolo Di Fiore, Nils Gauthier, Aldo Ferrari, Paolo Maiuri, Giorgio Scita
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/391b87a586fe4ec382591d31347a221d
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spelling oai:doaj.org-article:391b87a586fe4ec382591d31347a221d2021-12-02T14:39:05ZA RAB35-p85/PI3K axis controls oscillatory apical protrusions required for efficient chemotactic migration10.1038/s41467-018-03571-82041-1723https://doaj.org/article/391b87a586fe4ec382591d31347a221d2018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03571-8https://doaj.org/toc/2041-1723Circular dorsal ruffles (CDRs) are apical actin enriched structures involved in the interpretation of growth factor gradients during cell migration. Here, the authors find that a RAB35/PI3K axis is necessary and sufficient for the formation and stabilization of polarized CDRs and persistent directional migration.Salvatore CorallinoChiara MalinvernoBeate NeumannChristian TischerAndrea PalamidessiEmanuela FrittoliMagdalini PanagiotakopoulouAndrea DisanzaGema Malet-EngraPaulina NastalyCamilla GalliChiara LuiseGiovanni BertalotSalvatore PecePier Paolo Di FioreNils GauthierAldo FerrariPaolo MaiuriGiorgio ScitaNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-19 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Salvatore Corallino
Chiara Malinverno
Beate Neumann
Christian Tischer
Andrea Palamidessi
Emanuela Frittoli
Magdalini Panagiotakopoulou
Andrea Disanza
Gema Malet-Engra
Paulina Nastaly
Camilla Galli
Chiara Luise
Giovanni Bertalot
Salvatore Pece
Pier Paolo Di Fiore
Nils Gauthier
Aldo Ferrari
Paolo Maiuri
Giorgio Scita
A RAB35-p85/PI3K axis controls oscillatory apical protrusions required for efficient chemotactic migration
description Circular dorsal ruffles (CDRs) are apical actin enriched structures involved in the interpretation of growth factor gradients during cell migration. Here, the authors find that a RAB35/PI3K axis is necessary and sufficient for the formation and stabilization of polarized CDRs and persistent directional migration.
format article
author Salvatore Corallino
Chiara Malinverno
Beate Neumann
Christian Tischer
Andrea Palamidessi
Emanuela Frittoli
Magdalini Panagiotakopoulou
Andrea Disanza
Gema Malet-Engra
Paulina Nastaly
Camilla Galli
Chiara Luise
Giovanni Bertalot
Salvatore Pece
Pier Paolo Di Fiore
Nils Gauthier
Aldo Ferrari
Paolo Maiuri
Giorgio Scita
author_facet Salvatore Corallino
Chiara Malinverno
Beate Neumann
Christian Tischer
Andrea Palamidessi
Emanuela Frittoli
Magdalini Panagiotakopoulou
Andrea Disanza
Gema Malet-Engra
Paulina Nastaly
Camilla Galli
Chiara Luise
Giovanni Bertalot
Salvatore Pece
Pier Paolo Di Fiore
Nils Gauthier
Aldo Ferrari
Paolo Maiuri
Giorgio Scita
author_sort Salvatore Corallino
title A RAB35-p85/PI3K axis controls oscillatory apical protrusions required for efficient chemotactic migration
title_short A RAB35-p85/PI3K axis controls oscillatory apical protrusions required for efficient chemotactic migration
title_full A RAB35-p85/PI3K axis controls oscillatory apical protrusions required for efficient chemotactic migration
title_fullStr A RAB35-p85/PI3K axis controls oscillatory apical protrusions required for efficient chemotactic migration
title_full_unstemmed A RAB35-p85/PI3K axis controls oscillatory apical protrusions required for efficient chemotactic migration
title_sort rab35-p85/pi3k axis controls oscillatory apical protrusions required for efficient chemotactic migration
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/391b87a586fe4ec382591d31347a221d
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