A RAB35-p85/PI3K axis controls oscillatory apical protrusions required for efficient chemotactic migration

A RAB35-p85/PI3K axis controls oscillatory apical protrusions required for efficient chemotactic migration

Circular dorsal ruffles (CDRs) are apical actin enriched structures involved in the interpretation of growth factor gradients during cell migration. Here, the authors find that a RAB35/PI3K axis is necessary and sufficient for the formation and stabilization of polarized CDRs and persistent directio...

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Main Authors: Salvatore Corallino, Chiara Malinverno, Beate Neumann, Christian Tischer, Andrea Palamidessi, Emanuela Frittoli, Magdalini Panagiotakopoulou, Andrea Disanza, Gema Malet-Engra, Paulina Nastaly, Camilla Galli, Chiara Luise, Giovanni Bertalot, Salvatore Pece, Pier Paolo Di Fiore, Nils Gauthier, Aldo Ferrari, Paolo Maiuri, Giorgio Scita
Format: article
Language:EN
Published: Nature Portfolio 2018
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Science
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Online Access:https://doaj.org/article/391b87a586fe4ec382591d31347a221d
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https://doaj.org/article/391b87a586fe4ec382591d31347a221d

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