Two Health or Not Two Health? That Is the Question

ABSTRACT How much drug-resistant infections in livestock contribute to disease in humans is controversial. While zoonoses are a prominent cause of emerging infections, and the profligate use of antibiotics as growth promoters is expected to lead to the spread of resistance, this resistance could rem...

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Autor principal:	William P. Hanage
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2019
Materias:	Escherichia coli antibiotic resistance genomics molecular epidemiology One Health Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/391bf7e0a2974848bbb9e95e5395c734
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spelling	oai:doaj.org-article:391bf7e0a2974848bbb9e95e5395c7342021-11-15T15:55:26ZTwo Health or Not Two Health? That Is the Question10.1128/mBio.00550-192150-7511https://doaj.org/article/391bf7e0a2974848bbb9e95e5395c7342019-04-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.00550-19https://doaj.org/toc/2150-7511ABSTRACT How much drug-resistant infections in livestock contribute to disease in humans is controversial. While zoonoses are a prominent cause of emerging infections, and the profligate use of antibiotics as growth promoters is expected to lead to the spread of resistance, this resistance could remain concentrated in animal pathogens and only rarely spill over into humans. A recent paper compares genomes of Escherichia coli isolates from human bloodstream infections in England, focused on the Cambridge area, with isolates collected from farms and the food chain in the east of the country, seeking evidence of transmission (C. Ludden, K. E. Raven, D. Jamrozy, T. Gouliouris, et al., mBio 10:e02693-18, 2019, https://doi.org/10.1128/mBio.02693-18). While the human and livestock populations were clearly distinct, with very limited evidence for transmission of E. coli or resistance elements to humans, the results also illustrate our limited ability to infer historical transmission events from even the best samples. The implications for the One Health framework, aiming to unify human and veterinary medicine, are discussed.William P. HanageAmerican Society for MicrobiologyarticleEscherichia coliantibiotic resistancegenomicsmolecular epidemiologyOne HealthMicrobiologyQR1-502ENmBio, Vol 10, Iss 2 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Escherichia coli antibiotic resistance genomics molecular epidemiology One Health Microbiology QR1-502
spellingShingle	Escherichia coli antibiotic resistance genomics molecular epidemiology One Health Microbiology QR1-502 William P. Hanage Two Health or Not Two Health? That Is the Question
description	ABSTRACT How much drug-resistant infections in livestock contribute to disease in humans is controversial. While zoonoses are a prominent cause of emerging infections, and the profligate use of antibiotics as growth promoters is expected to lead to the spread of resistance, this resistance could remain concentrated in animal pathogens and only rarely spill over into humans. A recent paper compares genomes of Escherichia coli isolates from human bloodstream infections in England, focused on the Cambridge area, with isolates collected from farms and the food chain in the east of the country, seeking evidence of transmission (C. Ludden, K. E. Raven, D. Jamrozy, T. Gouliouris, et al., mBio 10:e02693-18, 2019, https://doi.org/10.1128/mBio.02693-18). While the human and livestock populations were clearly distinct, with very limited evidence for transmission of E. coli or resistance elements to humans, the results also illustrate our limited ability to infer historical transmission events from even the best samples. The implications for the One Health framework, aiming to unify human and veterinary medicine, are discussed.
format	article
author	William P. Hanage
author_facet	William P. Hanage
author_sort	William P. Hanage
title	Two Health or Not Two Health? That Is the Question
title_short	Two Health or Not Two Health? That Is the Question
title_full	Two Health or Not Two Health? That Is the Question
title_fullStr	Two Health or Not Two Health? That Is the Question
title_full_unstemmed	Two Health or Not Two Health? That Is the Question
title_sort	two health or not two health? that is the question
publisher	American Society for Microbiology
publishDate	2019
url	https://doaj.org/article/391bf7e0a2974848bbb9e95e5395c734
work_keys_str_mv	AT williamphanage twohealthornottwohealththatisthequestion
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Two Health or Not Two Health? That Is the Question

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