Thbs1 induces lethal cardiac atrophy through PERK-ATF4 regulated autophagy

Beneficial and detrimental effects have been ascribed to the different Thrombospondin (Thbs) proteins in the adult mammalian heart. Here, the authors show that Thbs1-mediated activation of PERK-eIF2α-ATF4-induced autophagy regulates adult cardiomyocyte size in the stressed heart.

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Autores principales: Davy Vanhoutte, Tobias G. Schips, Alexander Vo, Kelly M. Grimes, Tanya A. Baldwin, Matthew J. Brody, Federica Accornero, Michelle A. Sargent, Jeffery D. Molkentin
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/391d00d31af043e1bbe47abd09087451
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spelling oai:doaj.org-article:391d00d31af043e1bbe47abd090874512021-12-02T17:12:20ZThbs1 induces lethal cardiac atrophy through PERK-ATF4 regulated autophagy10.1038/s41467-021-24215-42041-1723https://doaj.org/article/391d00d31af043e1bbe47abd090874512021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24215-4https://doaj.org/toc/2041-1723Beneficial and detrimental effects have been ascribed to the different Thrombospondin (Thbs) proteins in the adult mammalian heart. Here, the authors show that Thbs1-mediated activation of PERK-eIF2α-ATF4-induced autophagy regulates adult cardiomyocyte size in the stressed heart.Davy VanhoutteTobias G. SchipsAlexander VoKelly M. GrimesTanya A. BaldwinMatthew J. BrodyFederica AccorneroMichelle A. SargentJeffery D. MolkentinNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Davy Vanhoutte
Tobias G. Schips
Alexander Vo
Kelly M. Grimes
Tanya A. Baldwin
Matthew J. Brody
Federica Accornero
Michelle A. Sargent
Jeffery D. Molkentin
Thbs1 induces lethal cardiac atrophy through PERK-ATF4 regulated autophagy
description Beneficial and detrimental effects have been ascribed to the different Thrombospondin (Thbs) proteins in the adult mammalian heart. Here, the authors show that Thbs1-mediated activation of PERK-eIF2α-ATF4-induced autophagy regulates adult cardiomyocyte size in the stressed heart.
format article
author Davy Vanhoutte
Tobias G. Schips
Alexander Vo
Kelly M. Grimes
Tanya A. Baldwin
Matthew J. Brody
Federica Accornero
Michelle A. Sargent
Jeffery D. Molkentin
author_facet Davy Vanhoutte
Tobias G. Schips
Alexander Vo
Kelly M. Grimes
Tanya A. Baldwin
Matthew J. Brody
Federica Accornero
Michelle A. Sargent
Jeffery D. Molkentin
author_sort Davy Vanhoutte
title Thbs1 induces lethal cardiac atrophy through PERK-ATF4 regulated autophagy
title_short Thbs1 induces lethal cardiac atrophy through PERK-ATF4 regulated autophagy
title_full Thbs1 induces lethal cardiac atrophy through PERK-ATF4 regulated autophagy
title_fullStr Thbs1 induces lethal cardiac atrophy through PERK-ATF4 regulated autophagy
title_full_unstemmed Thbs1 induces lethal cardiac atrophy through PERK-ATF4 regulated autophagy
title_sort thbs1 induces lethal cardiac atrophy through perk-atf4 regulated autophagy
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/391d00d31af043e1bbe47abd09087451
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