Thbs1 induces lethal cardiac atrophy through PERK-ATF4 regulated autophagy
Beneficial and detrimental effects have been ascribed to the different Thrombospondin (Thbs) proteins in the adult mammalian heart. Here, the authors show that Thbs1-mediated activation of PERK-eIF2α-ATF4-induced autophagy regulates adult cardiomyocyte size in the stressed heart.
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Nature Portfolio
2021
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oai:doaj.org-article:391d00d31af043e1bbe47abd090874512021-12-02T17:12:20ZThbs1 induces lethal cardiac atrophy through PERK-ATF4 regulated autophagy10.1038/s41467-021-24215-42041-1723https://doaj.org/article/391d00d31af043e1bbe47abd090874512021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24215-4https://doaj.org/toc/2041-1723Beneficial and detrimental effects have been ascribed to the different Thrombospondin (Thbs) proteins in the adult mammalian heart. Here, the authors show that Thbs1-mediated activation of PERK-eIF2α-ATF4-induced autophagy regulates adult cardiomyocyte size in the stressed heart.Davy VanhoutteTobias G. SchipsAlexander VoKelly M. GrimesTanya A. BaldwinMatthew J. BrodyFederica AccorneroMichelle A. SargentJeffery D. MolkentinNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021) |
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Science Q Davy Vanhoutte Tobias G. Schips Alexander Vo Kelly M. Grimes Tanya A. Baldwin Matthew J. Brody Federica Accornero Michelle A. Sargent Jeffery D. Molkentin Thbs1 induces lethal cardiac atrophy through PERK-ATF4 regulated autophagy |
description |
Beneficial and detrimental effects have been ascribed to the different Thrombospondin (Thbs) proteins in the adult mammalian heart. Here, the authors show that Thbs1-mediated activation of PERK-eIF2α-ATF4-induced autophagy regulates adult cardiomyocyte size in the stressed heart. |
format |
article |
author |
Davy Vanhoutte Tobias G. Schips Alexander Vo Kelly M. Grimes Tanya A. Baldwin Matthew J. Brody Federica Accornero Michelle A. Sargent Jeffery D. Molkentin |
author_facet |
Davy Vanhoutte Tobias G. Schips Alexander Vo Kelly M. Grimes Tanya A. Baldwin Matthew J. Brody Federica Accornero Michelle A. Sargent Jeffery D. Molkentin |
author_sort |
Davy Vanhoutte |
title |
Thbs1 induces lethal cardiac atrophy through PERK-ATF4 regulated autophagy |
title_short |
Thbs1 induces lethal cardiac atrophy through PERK-ATF4 regulated autophagy |
title_full |
Thbs1 induces lethal cardiac atrophy through PERK-ATF4 regulated autophagy |
title_fullStr |
Thbs1 induces lethal cardiac atrophy through PERK-ATF4 regulated autophagy |
title_full_unstemmed |
Thbs1 induces lethal cardiac atrophy through PERK-ATF4 regulated autophagy |
title_sort |
thbs1 induces lethal cardiac atrophy through perk-atf4 regulated autophagy |
publisher |
Nature Portfolio |
publishDate |
2021 |
url |
https://doaj.org/article/391d00d31af043e1bbe47abd09087451 |
work_keys_str_mv |
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_version_ |
1718381427270090752 |