Phenazine production promotes antibiotic tolerance and metabolic heterogeneity in Pseudomonas aeruginosa biofilms

Pseudomonas aeruginosa releases redox-active metabolites called phenazines. Here, the authors use metabolic imaging by stimulated Raman scattering microscopy to show that phenazines antagonize the effects of antibiotics on P. aeruginosa biofilms by modulating bacterial metabolism.

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Autores principales:	Konstanze T. Schiessl, Fanghao Hu, Jeanyoung Jo, Sakila Z. Nazia, Bryan Wang, Alexa Price-Whelan, Wei Min, Lars E. P. Dietrich
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/391da8e46f344a68bdd44bdb1155726c
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spelling	oai:doaj.org-article:391da8e46f344a68bdd44bdb1155726c2021-12-02T14:39:57ZPhenazine production promotes antibiotic tolerance and metabolic heterogeneity in Pseudomonas aeruginosa biofilms10.1038/s41467-019-08733-w2041-1723https://doaj.org/article/391da8e46f344a68bdd44bdb1155726c2019-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-08733-whttps://doaj.org/toc/2041-1723Pseudomonas aeruginosa releases redox-active metabolites called phenazines. Here, the authors use metabolic imaging by stimulated Raman scattering microscopy to show that phenazines antagonize the effects of antibiotics on P. aeruginosa biofilms by modulating bacterial metabolism.Konstanze T. SchiesslFanghao HuJeanyoung JoSakila Z. NaziaBryan WangAlexa Price-WhelanWei MinLars E. P. DietrichNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Konstanze T. Schiessl Fanghao Hu Jeanyoung Jo Sakila Z. Nazia Bryan Wang Alexa Price-Whelan Wei Min Lars E. P. Dietrich Phenazine production promotes antibiotic tolerance and metabolic heterogeneity in Pseudomonas aeruginosa biofilms
description	Pseudomonas aeruginosa releases redox-active metabolites called phenazines. Here, the authors use metabolic imaging by stimulated Raman scattering microscopy to show that phenazines antagonize the effects of antibiotics on P. aeruginosa biofilms by modulating bacterial metabolism.
format	article
author	Konstanze T. Schiessl Fanghao Hu Jeanyoung Jo Sakila Z. Nazia Bryan Wang Alexa Price-Whelan Wei Min Lars E. P. Dietrich
author_facet	Konstanze T. Schiessl Fanghao Hu Jeanyoung Jo Sakila Z. Nazia Bryan Wang Alexa Price-Whelan Wei Min Lars E. P. Dietrich
author_sort	Konstanze T. Schiessl
title	Phenazine production promotes antibiotic tolerance and metabolic heterogeneity in Pseudomonas aeruginosa biofilms
title_short	Phenazine production promotes antibiotic tolerance and metabolic heterogeneity in Pseudomonas aeruginosa biofilms
title_full	Phenazine production promotes antibiotic tolerance and metabolic heterogeneity in Pseudomonas aeruginosa biofilms
title_fullStr	Phenazine production promotes antibiotic tolerance and metabolic heterogeneity in Pseudomonas aeruginosa biofilms
title_full_unstemmed	Phenazine production promotes antibiotic tolerance and metabolic heterogeneity in Pseudomonas aeruginosa biofilms
title_sort	phenazine production promotes antibiotic tolerance and metabolic heterogeneity in pseudomonas aeruginosa biofilms
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/391da8e46f344a68bdd44bdb1155726c
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Phenazine production promotes antibiotic tolerance and metabolic heterogeneity in Pseudomonas aeruginosa biofilms

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