CLINICAL SIGNIFICANCE OF Toll2, Toll4, CD14, AND HLA-DR EXPRESSION ON THE MONOCYTES IN PATIENTS WITH SEPSIS

Expression of Toll-like receptors (TLRs) on myeloid cells is of key importance for induction of systemic reactions caused by bacterial damage, and activation mechanisms of innate immune response. The study included thirty-six patients with sepsis in whom we assessed a prognostic value of TLR2, TLR4,...

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Autores principales:	V. A. Lazanovich, E. V. Markelova, G. A. Smirnov, T. P. Smolina
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2015
Materias:	toll-like receptors monocytes sepsis Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/391ffc98583b49f3bcc33354ac1ce1f0
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spelling	oai:doaj.org-article:391ffc98583b49f3bcc33354ac1ce1f02021-11-18T08:03:44ZCLINICAL SIGNIFICANCE OF Toll2, Toll4, CD14, AND HLA-DR EXPRESSION ON THE MONOCYTES IN PATIENTS WITH SEPSIS1563-06252313-741X10.15789/1563-0625-2015-3-221-228https://doaj.org/article/391ffc98583b49f3bcc33354ac1ce1f02015-06-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/886https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XExpression of Toll-like receptors (TLRs) on myeloid cells is of key importance for induction of systemic reactions caused by bacterial damage, and activation mechanisms of innate immune response. The study included thirty-six patients with sepsis in whom we assessed a prognostic value of TLR2, TLR4, CD14, HLA-DR expressed on monocytes, depending on severity of the disease and clinical outcomes. There were neither significant differences in TLR4 expression at all stages of clinical observation, nor correlations between expression of this marker on monocytes and severity of the disease, or outcomes of septic conditions. Low levels of MFI on monocytes TLR2, HLA-DR at 5 and 10 days, like as decreased expression of CD14 on 10th day of the disease were shown to be predictive for poor clinical outcomes of sepsis.V. A. LazanovichE. V. MarkelovaG. A. SmirnovT. P. SmolinaSPb RAACIarticletoll-like receptorsmonocytessepsisImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 17, Iss 3, Pp 221-228 (2015)
institution	DOAJ
collection	DOAJ
language	RU
topic	toll-like receptors monocytes sepsis Immunologic diseases. Allergy RC581-607
spellingShingle	toll-like receptors monocytes sepsis Immunologic diseases. Allergy RC581-607 V. A. Lazanovich E. V. Markelova G. A. Smirnov T. P. Smolina CLINICAL SIGNIFICANCE OF Toll2, Toll4, CD14, AND HLA-DR EXPRESSION ON THE MONOCYTES IN PATIENTS WITH SEPSIS
description	Expression of Toll-like receptors (TLRs) on myeloid cells is of key importance for induction of systemic reactions caused by bacterial damage, and activation mechanisms of innate immune response. The study included thirty-six patients with sepsis in whom we assessed a prognostic value of TLR2, TLR4, CD14, HLA-DR expressed on monocytes, depending on severity of the disease and clinical outcomes. There were neither significant differences in TLR4 expression at all stages of clinical observation, nor correlations between expression of this marker on monocytes and severity of the disease, or outcomes of septic conditions. Low levels of MFI on monocytes TLR2, HLA-DR at 5 and 10 days, like as decreased expression of CD14 on 10th day of the disease were shown to be predictive for poor clinical outcomes of sepsis.
format	article
author	V. A. Lazanovich E. V. Markelova G. A. Smirnov T. P. Smolina
author_facet	V. A. Lazanovich E. V. Markelova G. A. Smirnov T. P. Smolina
author_sort	V. A. Lazanovich
title	CLINICAL SIGNIFICANCE OF Toll2, Toll4, CD14, AND HLA-DR EXPRESSION ON THE MONOCYTES IN PATIENTS WITH SEPSIS
title_short	CLINICAL SIGNIFICANCE OF Toll2, Toll4, CD14, AND HLA-DR EXPRESSION ON THE MONOCYTES IN PATIENTS WITH SEPSIS
title_full	CLINICAL SIGNIFICANCE OF Toll2, Toll4, CD14, AND HLA-DR EXPRESSION ON THE MONOCYTES IN PATIENTS WITH SEPSIS
title_fullStr	CLINICAL SIGNIFICANCE OF Toll2, Toll4, CD14, AND HLA-DR EXPRESSION ON THE MONOCYTES IN PATIENTS WITH SEPSIS
title_full_unstemmed	CLINICAL SIGNIFICANCE OF Toll2, Toll4, CD14, AND HLA-DR EXPRESSION ON THE MONOCYTES IN PATIENTS WITH SEPSIS
title_sort	clinical significance of toll2, toll4, cd14, and hla-dr expression on the monocytes in patients with sepsis
publisher	SPb RAACI
publishDate	2015
url	https://doaj.org/article/391ffc98583b49f3bcc33354ac1ce1f0
work_keys_str_mv	AT valazanovich clinicalsignificanceoftoll2toll4cd14andhladrexpressiononthemonocytesinpatientswithsepsis AT evmarkelova clinicalsignificanceoftoll2toll4cd14andhladrexpressiononthemonocytesinpatientswithsepsis AT gasmirnov clinicalsignificanceoftoll2toll4cd14andhladrexpressiononthemonocytesinpatientswithsepsis AT tpsmolina clinicalsignificanceoftoll2toll4cd14andhladrexpressiononthemonocytesinpatientswithsepsis
_version_	1718422409623633920

CLINICAL SIGNIFICANCE OF Toll2, Toll4, CD14, AND HLA-DR EXPRESSION ON THE MONOCYTES IN PATIENTS WITH SEPSIS

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