Emerging Impact of Non-coding RNAs in the Pathology of Stroke

Ischemic stroke (IS) is an acute cerebral vascular event with high mortality and morbidity. Though the precise pathophysiologic routes leading to this condition are not entirely clarified, growing evidence from animal and human experiments has exhibited the impact of non-coding RNAs in the pathogene...

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Autores principales:	Soudeh Ghafouri-Fard, Zeinab Shirvani-Farsani, Bashdar Mahmud Hussen, Mohammad Taheri, Noormohammad Arefian
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	lncRNA miRNA stroke expression biomarker Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/39208a0c4e8e4c338e866a81683b1ed5
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id	oai:doaj.org-article:39208a0c4e8e4c338e866a81683b1ed5
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spelling	oai:doaj.org-article:39208a0c4e8e4c338e866a81683b1ed52021-11-19T07:42:11ZEmerging Impact of Non-coding RNAs in the Pathology of Stroke1663-436510.3389/fnagi.2021.780489https://doaj.org/article/39208a0c4e8e4c338e866a81683b1ed52021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnagi.2021.780489/fullhttps://doaj.org/toc/1663-4365Ischemic stroke (IS) is an acute cerebral vascular event with high mortality and morbidity. Though the precise pathophysiologic routes leading to this condition are not entirely clarified, growing evidence from animal and human experiments has exhibited the impact of non-coding RNAs in the pathogenesis of IS. Various lncRNAs namely MALAT1, linc-SLC22A2, linc-OBP2B-1, linc_luo_1172, linc-DHFRL1-4, SNHG15, linc-FAM98A-3, H19, MEG3, ANRIL, MIAT, and GAS5 are possibly involved in the pathogenesis of IS. Meanwhile, lots of miRNAs contribute in this process. Differential expression of lncRNAs and miRNAs in the sera of IS patients versus unaffected individuals has endowed these transcripts the aptitude to distinguish at risk patients. Despite conduction of comprehensive assays for evaluation of the influence of lncRNAs/miRNAs in the pathogenesis of IS, therapeutic impacts of these transcripts in IS have not been clarified. In the present paper, we review the impact of lncRNAs/miRNAs in the pathobiology of IS through assessment of evidence provided by human and animal studies.Soudeh Ghafouri-FardZeinab Shirvani-FarsaniBashdar Mahmud HussenMohammad TaheriNoormohammad ArefianFrontiers Media S.A.articlelncRNAmiRNAstrokeexpressionbiomarkerNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Aging Neuroscience, Vol 13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	lncRNA miRNA stroke expression biomarker Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	lncRNA miRNA stroke expression biomarker Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Soudeh Ghafouri-Fard Zeinab Shirvani-Farsani Bashdar Mahmud Hussen Mohammad Taheri Noormohammad Arefian Emerging Impact of Non-coding RNAs in the Pathology of Stroke
description	Ischemic stroke (IS) is an acute cerebral vascular event with high mortality and morbidity. Though the precise pathophysiologic routes leading to this condition are not entirely clarified, growing evidence from animal and human experiments has exhibited the impact of non-coding RNAs in the pathogenesis of IS. Various lncRNAs namely MALAT1, linc-SLC22A2, linc-OBP2B-1, linc_luo_1172, linc-DHFRL1-4, SNHG15, linc-FAM98A-3, H19, MEG3, ANRIL, MIAT, and GAS5 are possibly involved in the pathogenesis of IS. Meanwhile, lots of miRNAs contribute in this process. Differential expression of lncRNAs and miRNAs in the sera of IS patients versus unaffected individuals has endowed these transcripts the aptitude to distinguish at risk patients. Despite conduction of comprehensive assays for evaluation of the influence of lncRNAs/miRNAs in the pathogenesis of IS, therapeutic impacts of these transcripts in IS have not been clarified. In the present paper, we review the impact of lncRNAs/miRNAs in the pathobiology of IS through assessment of evidence provided by human and animal studies.
format	article
author	Soudeh Ghafouri-Fard Zeinab Shirvani-Farsani Bashdar Mahmud Hussen Mohammad Taheri Noormohammad Arefian
author_facet	Soudeh Ghafouri-Fard Zeinab Shirvani-Farsani Bashdar Mahmud Hussen Mohammad Taheri Noormohammad Arefian
author_sort	Soudeh Ghafouri-Fard
title	Emerging Impact of Non-coding RNAs in the Pathology of Stroke
title_short	Emerging Impact of Non-coding RNAs in the Pathology of Stroke
title_full	Emerging Impact of Non-coding RNAs in the Pathology of Stroke
title_fullStr	Emerging Impact of Non-coding RNAs in the Pathology of Stroke
title_full_unstemmed	Emerging Impact of Non-coding RNAs in the Pathology of Stroke
title_sort	emerging impact of non-coding rnas in the pathology of stroke
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/39208a0c4e8e4c338e866a81683b1ed5
work_keys_str_mv	AT soudehghafourifard emergingimpactofnoncodingrnasinthepathologyofstroke AT zeinabshirvanifarsani emergingimpactofnoncodingrnasinthepathologyofstroke AT bashdarmahmudhussen emergingimpactofnoncodingrnasinthepathologyofstroke AT mohammadtaheri emergingimpactofnoncodingrnasinthepathologyofstroke AT noormohammadarefian emergingimpactofnoncodingrnasinthepathologyofstroke
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Emerging Impact of Non-coding RNAs in the Pathology of Stroke

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