Drosophila neurotrophins reveal a common mechanism for nervous system formation.

Neurotrophic interactions occur in Drosophila, but to date, no neurotrophic factor had been found. Neurotrophins are the main vertebrate secreted signalling molecules that link nervous system structure and function: they regulate neuronal survival, targeting, synaptic plasticity, memory and cognitio...

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Autores principales:	Bangfu Zhu, Jenny A Pennack, Peter McQuilton, Manuel G Forero, Kenji Mizuguchi, Ben Sutcliffe, Chun-Jing Gu, Janine C Fenton, Alicia Hidalgo
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2008
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/3920974e2c8c4f8aa84b63b899a3effa
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spelling	oai:doaj.org-article:3920974e2c8c4f8aa84b63b899a3effa2021-12-02T19:54:30ZDrosophila neurotrophins reveal a common mechanism for nervous system formation.1544-91731545-788510.1371/journal.pbio.0060284https://doaj.org/article/3920974e2c8c4f8aa84b63b899a3effa2008-11-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/19018662/?tool=EBIhttps://doaj.org/toc/1544-9173https://doaj.org/toc/1545-7885Neurotrophic interactions occur in Drosophila, but to date, no neurotrophic factor had been found. Neurotrophins are the main vertebrate secreted signalling molecules that link nervous system structure and function: they regulate neuronal survival, targeting, synaptic plasticity, memory and cognition. We have identified a neurotrophic factor in flies, Drosophila Neurotrophin (DNT1), structurally related to all known neurotrophins and highly conserved in insects. By investigating with genetics the consequences of removing DNT1 or adding it in excess, we show that DNT1 maintains neuronal survival, as more neurons die in DNT1 mutants and expression of DNT1 rescues naturally occurring cell death, and it enables targeting by motor neurons. We show that Spätzle and a further fly neurotrophin superfamily member, DNT2, also have neurotrophic functions in flies. Our findings imply that most likely a neurotrophin was present in the common ancestor of all bilateral organisms, giving rise to invertebrate and vertebrate neurotrophins through gene or whole-genome duplications. This work provides a missing link between aspects of neuronal function in flies and vertebrates, and it opens the opportunity to use Drosophila to investigate further aspects of neurotrophin function and to model related diseases.Bangfu ZhuJenny A PennackPeter McQuiltonManuel G ForeroKenji MizuguchiBen SutcliffeChun-Jing GuJanine C FentonAlicia HidalgoPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Biology, Vol 6, Iss 11, p e284 (2008)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Bangfu Zhu Jenny A Pennack Peter McQuilton Manuel G Forero Kenji Mizuguchi Ben Sutcliffe Chun-Jing Gu Janine C Fenton Alicia Hidalgo Drosophila neurotrophins reveal a common mechanism for nervous system formation.
description	Neurotrophic interactions occur in Drosophila, but to date, no neurotrophic factor had been found. Neurotrophins are the main vertebrate secreted signalling molecules that link nervous system structure and function: they regulate neuronal survival, targeting, synaptic plasticity, memory and cognition. We have identified a neurotrophic factor in flies, Drosophila Neurotrophin (DNT1), structurally related to all known neurotrophins and highly conserved in insects. By investigating with genetics the consequences of removing DNT1 or adding it in excess, we show that DNT1 maintains neuronal survival, as more neurons die in DNT1 mutants and expression of DNT1 rescues naturally occurring cell death, and it enables targeting by motor neurons. We show that Spätzle and a further fly neurotrophin superfamily member, DNT2, also have neurotrophic functions in flies. Our findings imply that most likely a neurotrophin was present in the common ancestor of all bilateral organisms, giving rise to invertebrate and vertebrate neurotrophins through gene or whole-genome duplications. This work provides a missing link between aspects of neuronal function in flies and vertebrates, and it opens the opportunity to use Drosophila to investigate further aspects of neurotrophin function and to model related diseases.
format	article
author	Bangfu Zhu Jenny A Pennack Peter McQuilton Manuel G Forero Kenji Mizuguchi Ben Sutcliffe Chun-Jing Gu Janine C Fenton Alicia Hidalgo
author_facet	Bangfu Zhu Jenny A Pennack Peter McQuilton Manuel G Forero Kenji Mizuguchi Ben Sutcliffe Chun-Jing Gu Janine C Fenton Alicia Hidalgo
author_sort	Bangfu Zhu
title	Drosophila neurotrophins reveal a common mechanism for nervous system formation.
title_short	Drosophila neurotrophins reveal a common mechanism for nervous system formation.
title_full	Drosophila neurotrophins reveal a common mechanism for nervous system formation.
title_fullStr	Drosophila neurotrophins reveal a common mechanism for nervous system formation.
title_full_unstemmed	Drosophila neurotrophins reveal a common mechanism for nervous system formation.
title_sort	drosophila neurotrophins reveal a common mechanism for nervous system formation.
publisher	Public Library of Science (PLoS)
publishDate	2008
url	https://doaj.org/article/3920974e2c8c4f8aa84b63b899a3effa
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Drosophila neurotrophins reveal a common mechanism for nervous system formation.

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