Fighting the Monster: Applying the Host Damage Framework to Human Central Nervous System Infections

ABSTRACT The host damage-response framework states that microbial pathogenesis is a product of microbial virulence factors and collateral damage from host immune responses. Immune-mediated host damage is particularly important within the size-restricted central nervous system (CNS), where immune res...

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Autores principales:	Anil A. Panackal, Kim C. Williamson, Diederik van de Beek, David R. Boulware, Peter R. Williamson
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2016
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/39226142e39b43ccbbf6ed5771f02c7b
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spelling	oai:doaj.org-article:39226142e39b43ccbbf6ed5771f02c7b2021-11-15T15:49:40ZFighting the Monster: Applying the Host Damage Framework to Human Central Nervous System Infections10.1128/mBio.01906-152150-7511https://doaj.org/article/39226142e39b43ccbbf6ed5771f02c7b2016-03-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.01906-15https://doaj.org/toc/2150-7511ABSTRACT The host damage-response framework states that microbial pathogenesis is a product of microbial virulence factors and collateral damage from host immune responses. Immune-mediated host damage is particularly important within the size-restricted central nervous system (CNS), where immune responses may exacerbate cerebral edema and neurological damage, leading to coma and death. In this review, we compare human host and therapeutic responses in representative nonviral generalized CNS infections that induce archetypal host damage responses: cryptococcal menigoencephalitis and tuberculous meningitis in HIV-infected and non-HIV-infected patients, pneumococcal meningitis, and cerebral malaria. Consideration of the underlying patterns of host responses provides critical insights into host damage and may suggest tailored adjunctive therapeutics to improve disease outcome.Anil A. PanackalKim C. WilliamsonDiederik van de BeekDavid R. BoulwarePeter R. WilliamsonAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 7, Iss 1 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Anil A. Panackal Kim C. Williamson Diederik van de Beek David R. Boulware Peter R. Williamson Fighting the Monster: Applying the Host Damage Framework to Human Central Nervous System Infections
description	ABSTRACT The host damage-response framework states that microbial pathogenesis is a product of microbial virulence factors and collateral damage from host immune responses. Immune-mediated host damage is particularly important within the size-restricted central nervous system (CNS), where immune responses may exacerbate cerebral edema and neurological damage, leading to coma and death. In this review, we compare human host and therapeutic responses in representative nonviral generalized CNS infections that induce archetypal host damage responses: cryptococcal menigoencephalitis and tuberculous meningitis in HIV-infected and non-HIV-infected patients, pneumococcal meningitis, and cerebral malaria. Consideration of the underlying patterns of host responses provides critical insights into host damage and may suggest tailored adjunctive therapeutics to improve disease outcome.
format	article
author	Anil A. Panackal Kim C. Williamson Diederik van de Beek David R. Boulware Peter R. Williamson
author_facet	Anil A. Panackal Kim C. Williamson Diederik van de Beek David R. Boulware Peter R. Williamson
author_sort	Anil A. Panackal
title	Fighting the Monster: Applying the Host Damage Framework to Human Central Nervous System Infections
title_short	Fighting the Monster: Applying the Host Damage Framework to Human Central Nervous System Infections
title_full	Fighting the Monster: Applying the Host Damage Framework to Human Central Nervous System Infections
title_fullStr	Fighting the Monster: Applying the Host Damage Framework to Human Central Nervous System Infections
title_full_unstemmed	Fighting the Monster: Applying the Host Damage Framework to Human Central Nervous System Infections
title_sort	fighting the monster: applying the host damage framework to human central nervous system infections
publisher	American Society for Microbiology
publishDate	2016
url	https://doaj.org/article/39226142e39b43ccbbf6ed5771f02c7b
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Fighting the Monster: Applying the Host Damage Framework to Human Central Nervous System Infections

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