Dinucleosome specificity and allosteric switch of the ISW1a ATP-dependent chromatin remodeler in transcription regulation

Here the authors show that the preference of yeast chromatin remodeler ISW1a for dinucleosomes hinges on conformational changes that occur in the transition from binding mononucleosomes to dinucleosomes. These changes are critical for ISW1a organizing chromatin at promoters and regulating transcript...

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Autores principales:	Saurabh K. Bhardwaj, Solomon G. Hailu, Lola Olufemi, Sandipan Brahma, Soumyadipta Kundu, Swetansu K. Hota, Jim Persinger, Blaine Bartholomew
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3925090b229e433189477ec58c630f47
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spelling	oai:doaj.org-article:3925090b229e433189477ec58c630f472021-12-02T17:31:54ZDinucleosome specificity and allosteric switch of the ISW1a ATP-dependent chromatin remodeler in transcription regulation10.1038/s41467-020-19700-12041-1723https://doaj.org/article/3925090b229e433189477ec58c630f472020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19700-1https://doaj.org/toc/2041-1723Here the authors show that the preference of yeast chromatin remodeler ISW1a for dinucleosomes hinges on conformational changes that occur in the transition from binding mononucleosomes to dinucleosomes. These changes are critical for ISW1a organizing chromatin at promoters and regulating transcription in conjunction with other chromatin remodelers.Saurabh K. BhardwajSolomon G. HailuLola OlufemiSandipan BrahmaSoumyadipta KunduSwetansu K. HotaJim PersingerBlaine BartholomewNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Saurabh K. Bhardwaj Solomon G. Hailu Lola Olufemi Sandipan Brahma Soumyadipta Kundu Swetansu K. Hota Jim Persinger Blaine Bartholomew Dinucleosome specificity and allosteric switch of the ISW1a ATP-dependent chromatin remodeler in transcription regulation
description	Here the authors show that the preference of yeast chromatin remodeler ISW1a for dinucleosomes hinges on conformational changes that occur in the transition from binding mononucleosomes to dinucleosomes. These changes are critical for ISW1a organizing chromatin at promoters and regulating transcription in conjunction with other chromatin remodelers.
format	article
author	Saurabh K. Bhardwaj Solomon G. Hailu Lola Olufemi Sandipan Brahma Soumyadipta Kundu Swetansu K. Hota Jim Persinger Blaine Bartholomew
author_facet	Saurabh K. Bhardwaj Solomon G. Hailu Lola Olufemi Sandipan Brahma Soumyadipta Kundu Swetansu K. Hota Jim Persinger Blaine Bartholomew
author_sort	Saurabh K. Bhardwaj
title	Dinucleosome specificity and allosteric switch of the ISW1a ATP-dependent chromatin remodeler in transcription regulation
title_short	Dinucleosome specificity and allosteric switch of the ISW1a ATP-dependent chromatin remodeler in transcription regulation
title_full	Dinucleosome specificity and allosteric switch of the ISW1a ATP-dependent chromatin remodeler in transcription regulation
title_fullStr	Dinucleosome specificity and allosteric switch of the ISW1a ATP-dependent chromatin remodeler in transcription regulation
title_full_unstemmed	Dinucleosome specificity and allosteric switch of the ISW1a ATP-dependent chromatin remodeler in transcription regulation
title_sort	dinucleosome specificity and allosteric switch of the isw1a atp-dependent chromatin remodeler in transcription regulation
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/3925090b229e433189477ec58c630f47
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Dinucleosome specificity and allosteric switch of the ISW1a ATP-dependent chromatin remodeler in transcription regulation

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