Dynamics of detailed components of metabolic syndrome associated with the risk of cardiovascular disease and death

Abstract Few studies quantify a cascade of dynamic transitions on the detailed components of metabolic syndrome (MetS) and subsequent progressions to cardiovascular disease (CVD) and its death. A total of 47,495 subjects repeatedly attending a community-based integrated screening program in Taiwan w...

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Autores principales:	Ting-Yu Lin, Kuo-Liong Chien, Yueh-Hsia Chiu, Pi-Chun Chuang, Ming-Fang Yen, Hsiu-Hsi Chen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3925bae5ccca47d6b2ce274d21ce3097
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spelling	oai:doaj.org-article:3925bae5ccca47d6b2ce274d21ce30972021-12-02T12:09:51ZDynamics of detailed components of metabolic syndrome associated with the risk of cardiovascular disease and death10.1038/s41598-021-83118-y2045-2322https://doaj.org/article/3925bae5ccca47d6b2ce274d21ce30972021-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-83118-yhttps://doaj.org/toc/2045-2322Abstract Few studies quantify a cascade of dynamic transitions on the detailed components of metabolic syndrome (MetS) and subsequent progressions to cardiovascular disease (CVD) and its death. A total of 47,495 subjects repeatedly attending a community-based integrated screening program in Taiwan were recruited. The refined MetS-related classification (RMRC) in relation to five criteria of MetS was defined as free of metabolic disorder (FMD, none of any criteria), mild metabolic disorder (MMD, 1–2 criteria) and MetS. A multistate Markov model was used for modelling such a multistate process. The estimated progression rate from FMD to MMD was 44.82% (95% CI 42.95–46.70%) whereas the regression rate was estimated as 29.11% (95% CI 27.77–30.45%). The progression rate from MMD to MetS was estimated as 6.15% (95% CI 5.89–6.42%). The estimated annual incidence rates of CVD increased with the severity of RMRC, being 1.62% (95% CI 1.46–1.79%) for FMD, 4.74% (95% CI 4.52–4.96%) for MMD, to 20.22% (95% CI 19.52–20.92%) for MetS. The estimated hazard rate of CVD death was 6.1 (95% CI 4.6–7.7) per thousand. Elucidating the dynamics of MetS-related transition and quantifying the incidence and prognosis of CVD provide a new insight into the design and the evaluation of intervention programs for CVD.Ting-Yu LinKuo-Liong ChienYueh-Hsia ChiuPi-Chun ChuangMing-Fang YenHsiu-Hsi ChenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ting-Yu Lin Kuo-Liong Chien Yueh-Hsia Chiu Pi-Chun Chuang Ming-Fang Yen Hsiu-Hsi Chen Dynamics of detailed components of metabolic syndrome associated with the risk of cardiovascular disease and death
description	Abstract Few studies quantify a cascade of dynamic transitions on the detailed components of metabolic syndrome (MetS) and subsequent progressions to cardiovascular disease (CVD) and its death. A total of 47,495 subjects repeatedly attending a community-based integrated screening program in Taiwan were recruited. The refined MetS-related classification (RMRC) in relation to five criteria of MetS was defined as free of metabolic disorder (FMD, none of any criteria), mild metabolic disorder (MMD, 1–2 criteria) and MetS. A multistate Markov model was used for modelling such a multistate process. The estimated progression rate from FMD to MMD was 44.82% (95% CI 42.95–46.70%) whereas the regression rate was estimated as 29.11% (95% CI 27.77–30.45%). The progression rate from MMD to MetS was estimated as 6.15% (95% CI 5.89–6.42%). The estimated annual incidence rates of CVD increased with the severity of RMRC, being 1.62% (95% CI 1.46–1.79%) for FMD, 4.74% (95% CI 4.52–4.96%) for MMD, to 20.22% (95% CI 19.52–20.92%) for MetS. The estimated hazard rate of CVD death was 6.1 (95% CI 4.6–7.7) per thousand. Elucidating the dynamics of MetS-related transition and quantifying the incidence and prognosis of CVD provide a new insight into the design and the evaluation of intervention programs for CVD.
format	article
author	Ting-Yu Lin Kuo-Liong Chien Yueh-Hsia Chiu Pi-Chun Chuang Ming-Fang Yen Hsiu-Hsi Chen
author_facet	Ting-Yu Lin Kuo-Liong Chien Yueh-Hsia Chiu Pi-Chun Chuang Ming-Fang Yen Hsiu-Hsi Chen
author_sort	Ting-Yu Lin
title	Dynamics of detailed components of metabolic syndrome associated with the risk of cardiovascular disease and death
title_short	Dynamics of detailed components of metabolic syndrome associated with the risk of cardiovascular disease and death
title_full	Dynamics of detailed components of metabolic syndrome associated with the risk of cardiovascular disease and death
title_fullStr	Dynamics of detailed components of metabolic syndrome associated with the risk of cardiovascular disease and death
title_full_unstemmed	Dynamics of detailed components of metabolic syndrome associated with the risk of cardiovascular disease and death
title_sort	dynamics of detailed components of metabolic syndrome associated with the risk of cardiovascular disease and death
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3925bae5ccca47d6b2ce274d21ce3097
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Dynamics of detailed components of metabolic syndrome associated with the risk of cardiovascular disease and death

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