Granule Leakage Induces Cell-Intrinsic, Granzyme B-Mediated Apoptosis in Mast Cells

Mast cells are multifunctional immune cells scattered in tissues near blood vessels and mucosal surfaces where they mediate important reactions against parasites and contribute to the pathogenesis of allergic reactions. Serine proteases released from secretory granules upon mast cell activation cont...

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Autores principales: Sabrina Sofia Burgener, Melanie Brügger, Nathan Georges François Leborgne, Sophia Sollberger, Paola Basilico, Thomas Kaufmann, Phillip Ian Bird, Charaf Benarafa
Formato: article
Lenguaje:EN
Publicado: Frontiers Media S.A. 2021
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Acceso en línea:https://doaj.org/article/3926c7813b9048e8960603bad8c3adb4
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