Breast-conserving surgery with 3D-printed surgical guide: a single-center, prospective clinical study

Abstract To facilitate precise tumor resection at the time of breast-conserving surgery (BCS), we developed and implemented a magnetic resonance imaging (MRI)-based three-dimensional-printed (3DP) breast surgical guide (BSG). This prospective cohort study was conducted at a single institution from J...

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Autores principales:	Zhen-Yu Wu, Hee Jeong Kim, Jongwon Lee, Il Yong Chung, Jisun Kim, Saebyeol Lee, Byung Ho Son, Sei-Hyun Ahn, Hak Hee Kim, Joon Beom Seo, Jae Ho Jeong, Gyungyub Gong, Namkug Kim, BeomSeok Ko
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3929c0ae2e0e4fd8a5b2f6f1ac4c8886
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spelling	oai:doaj.org-article:3929c0ae2e0e4fd8a5b2f6f1ac4c88862021-12-02T13:57:37ZBreast-conserving surgery with 3D-printed surgical guide: a single-center, prospective clinical study10.1038/s41598-021-81936-82045-2322https://doaj.org/article/3929c0ae2e0e4fd8a5b2f6f1ac4c88862021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81936-8https://doaj.org/toc/2045-2322Abstract To facilitate precise tumor resection at the time of breast-conserving surgery (BCS), we developed and implemented a magnetic resonance imaging (MRI)-based three-dimensional-printed (3DP) breast surgical guide (BSG). This prospective cohort study was conducted at a single institution from July 2017 to February 2019 on women with breast cancer who underwent partial breast resection using patient-specific 3DP BSGs. Eighty-eight patients with invasive cancer were enrolled, of whom 1 patient had bilateral breast cancer. The mean size of the tumor long-axis on MRI before surgery was 2.8 ± 0.9 cm, and multiple tumors were observed in 34 patients. In 16 cases (18.0%), the resection margin was tumor-positive according to intraoperative frozen biopsy; all of these tumors were ductal carcinoma in situ and were re-excised intraoperatively. In 93.3% of the cases, the resection margin was tumor-free in the permanent pathology. The mean pathological tumor size was 1.7 ± 1.0 cm, and the mean distance from the tumor to the border was 1.5 ± 1.0 cm. This exploratory study showed that the tumor area on the MRI could be directly displayed on the breast when using a 3DP BSG for BCS, thereby allowing precise surgery and safe tumor removal. Trial Registration Clinical Research Information Service (CRIS) Identifier (No. KCT0002375, KCT0003043).Zhen-Yu WuHee Jeong KimJongwon LeeIl Yong ChungJisun KimSaebyeol LeeByung Ho SonSei-Hyun AhnHak Hee KimJoon Beom SeoJae Ho JeongGyungyub GongNamkug KimBeomSeok KoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Zhen-Yu Wu Hee Jeong Kim Jongwon Lee Il Yong Chung Jisun Kim Saebyeol Lee Byung Ho Son Sei-Hyun Ahn Hak Hee Kim Joon Beom Seo Jae Ho Jeong Gyungyub Gong Namkug Kim BeomSeok Ko Breast-conserving surgery with 3D-printed surgical guide: a single-center, prospective clinical study
description	Abstract To facilitate precise tumor resection at the time of breast-conserving surgery (BCS), we developed and implemented a magnetic resonance imaging (MRI)-based three-dimensional-printed (3DP) breast surgical guide (BSG). This prospective cohort study was conducted at a single institution from July 2017 to February 2019 on women with breast cancer who underwent partial breast resection using patient-specific 3DP BSGs. Eighty-eight patients with invasive cancer were enrolled, of whom 1 patient had bilateral breast cancer. The mean size of the tumor long-axis on MRI before surgery was 2.8 ± 0.9 cm, and multiple tumors were observed in 34 patients. In 16 cases (18.0%), the resection margin was tumor-positive according to intraoperative frozen biopsy; all of these tumors were ductal carcinoma in situ and were re-excised intraoperatively. In 93.3% of the cases, the resection margin was tumor-free in the permanent pathology. The mean pathological tumor size was 1.7 ± 1.0 cm, and the mean distance from the tumor to the border was 1.5 ± 1.0 cm. This exploratory study showed that the tumor area on the MRI could be directly displayed on the breast when using a 3DP BSG for BCS, thereby allowing precise surgery and safe tumor removal. Trial Registration Clinical Research Information Service (CRIS) Identifier (No. KCT0002375, KCT0003043).
format	article
author	Zhen-Yu Wu Hee Jeong Kim Jongwon Lee Il Yong Chung Jisun Kim Saebyeol Lee Byung Ho Son Sei-Hyun Ahn Hak Hee Kim Joon Beom Seo Jae Ho Jeong Gyungyub Gong Namkug Kim BeomSeok Ko
author_facet	Zhen-Yu Wu Hee Jeong Kim Jongwon Lee Il Yong Chung Jisun Kim Saebyeol Lee Byung Ho Son Sei-Hyun Ahn Hak Hee Kim Joon Beom Seo Jae Ho Jeong Gyungyub Gong Namkug Kim BeomSeok Ko
author_sort	Zhen-Yu Wu
title	Breast-conserving surgery with 3D-printed surgical guide: a single-center, prospective clinical study
title_short	Breast-conserving surgery with 3D-printed surgical guide: a single-center, prospective clinical study
title_full	Breast-conserving surgery with 3D-printed surgical guide: a single-center, prospective clinical study
title_fullStr	Breast-conserving surgery with 3D-printed surgical guide: a single-center, prospective clinical study
title_full_unstemmed	Breast-conserving surgery with 3D-printed surgical guide: a single-center, prospective clinical study
title_sort	breast-conserving surgery with 3d-printed surgical guide: a single-center, prospective clinical study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3929c0ae2e0e4fd8a5b2f6f1ac4c8886
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Breast-conserving surgery with 3D-printed surgical guide: a single-center, prospective clinical study

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