The High Impact of <i>Staphylococcus aureus</i> Biofilm Culture Medium on In Vitro Outcomes of Antimicrobial Activity of Wound Antiseptics and Antibiotic

The staphylococcal biofilm-based infections of wounds still pose a significant therapeutical challenge. Treated improperly, they increase the risk of limb amputation or even death of the patient. The present algorithms of infected wound treatment include, among others, the application of antiseptic...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Justyna Paleczny, Adam Junka, Malwina Brożyna, Karolina Dydak, Monika Oleksy-Wawrzyniak, Daria Ciecholewska-Juśko, Ewelina Dziedzic, Marzenna Bartoszewicz
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	biofilm <i>Staphylococcus aureus</i> wound infection exudate culture media antiseptics Medicine R
Acceso en línea:	https://doaj.org/article/392a37ce83cf47758435d3866b85bf09
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:392a37ce83cf47758435d3866b85bf09
record_format	dspace
spelling	oai:doaj.org-article:392a37ce83cf47758435d3866b85bf092021-11-25T18:37:49ZThe High Impact of <i>Staphylococcus aureus</i> Biofilm Culture Medium on In Vitro Outcomes of Antimicrobial Activity of Wound Antiseptics and Antibiotic10.3390/pathogens101113852076-0817https://doaj.org/article/392a37ce83cf47758435d3866b85bf092021-10-01T00:00:00Zhttps://www.mdpi.com/2076-0817/10/11/1385https://doaj.org/toc/2076-0817The staphylococcal biofilm-based infections of wounds still pose a significant therapeutical challenge. Treated improperly, they increase the risk of limb amputation or even death of the patient. The present algorithms of infected wound treatment include, among others, the application of antiseptic substances. In vitro wound biofilm models are applied in order to scrutinize their activity. In the present work, using a spectrum of techniques, we showed how the change of a single variable (medium composition) in the standard in vitro model translates not only to shift in staphylococcal biofilm features but also to the change of efficacy of clinically applied wound antimicrobials such as octenidine, polyhexamethylene biguanide, chlorhexidine, hypochlorite solutions, and locally applied gentamycin. The data presented in this study may be of a pivotal nature, taking into consideration the fact that results of in vitro analyses are frequently used to propagate application of specific antimicrobials in hospitals and ambulatory care units.Justyna PalecznyAdam JunkaMalwina BrożynaKarolina DydakMonika Oleksy-WawrzyniakDaria Ciecholewska-JuśkoEwelina DziedzicMarzenna BartoszewiczMDPI AGarticlebiofilm<i>Staphylococcus aureus</i>wound infectionexudateculture mediaantisepticsMedicineRENPathogens, Vol 10, Iss 1385, p 1385 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	biofilm <i>Staphylococcus aureus</i> wound infection exudate culture media antiseptics Medicine R
spellingShingle	biofilm <i>Staphylococcus aureus</i> wound infection exudate culture media antiseptics Medicine R Justyna Paleczny Adam Junka Malwina Brożyna Karolina Dydak Monika Oleksy-Wawrzyniak Daria Ciecholewska-Juśko Ewelina Dziedzic Marzenna Bartoszewicz The High Impact of <i>Staphylococcus aureus</i> Biofilm Culture Medium on In Vitro Outcomes of Antimicrobial Activity of Wound Antiseptics and Antibiotic
description	The staphylococcal biofilm-based infections of wounds still pose a significant therapeutical challenge. Treated improperly, they increase the risk of limb amputation or even death of the patient. The present algorithms of infected wound treatment include, among others, the application of antiseptic substances. In vitro wound biofilm models are applied in order to scrutinize their activity. In the present work, using a spectrum of techniques, we showed how the change of a single variable (medium composition) in the standard in vitro model translates not only to shift in staphylococcal biofilm features but also to the change of efficacy of clinically applied wound antimicrobials such as octenidine, polyhexamethylene biguanide, chlorhexidine, hypochlorite solutions, and locally applied gentamycin. The data presented in this study may be of a pivotal nature, taking into consideration the fact that results of in vitro analyses are frequently used to propagate application of specific antimicrobials in hospitals and ambulatory care units.
format	article
author	Justyna Paleczny Adam Junka Malwina Brożyna Karolina Dydak Monika Oleksy-Wawrzyniak Daria Ciecholewska-Juśko Ewelina Dziedzic Marzenna Bartoszewicz
author_facet	Justyna Paleczny Adam Junka Malwina Brożyna Karolina Dydak Monika Oleksy-Wawrzyniak Daria Ciecholewska-Juśko Ewelina Dziedzic Marzenna Bartoszewicz
author_sort	Justyna Paleczny
title	The High Impact of <i>Staphylococcus aureus</i> Biofilm Culture Medium on In Vitro Outcomes of Antimicrobial Activity of Wound Antiseptics and Antibiotic
title_short	The High Impact of <i>Staphylococcus aureus</i> Biofilm Culture Medium on In Vitro Outcomes of Antimicrobial Activity of Wound Antiseptics and Antibiotic
title_full	The High Impact of <i>Staphylococcus aureus</i> Biofilm Culture Medium on In Vitro Outcomes of Antimicrobial Activity of Wound Antiseptics and Antibiotic
title_fullStr	The High Impact of <i>Staphylococcus aureus</i> Biofilm Culture Medium on In Vitro Outcomes of Antimicrobial Activity of Wound Antiseptics and Antibiotic
title_full_unstemmed	The High Impact of <i>Staphylococcus aureus</i> Biofilm Culture Medium on In Vitro Outcomes of Antimicrobial Activity of Wound Antiseptics and Antibiotic
title_sort	high impact of <i>staphylococcus aureus</i> biofilm culture medium on in vitro outcomes of antimicrobial activity of wound antiseptics and antibiotic
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/392a37ce83cf47758435d3866b85bf09
work_keys_str_mv	AT justynapaleczny thehighimpactofistaphylococcusaureusibiofilmculturemediumoninvitrooutcomesofantimicrobialactivityofwoundantisepticsandantibiotic AT adamjunka thehighimpactofistaphylococcusaureusibiofilmculturemediumoninvitrooutcomesofantimicrobialactivityofwoundantisepticsandantibiotic AT malwinabrozyna thehighimpactofistaphylococcusaureusibiofilmculturemediumoninvitrooutcomesofantimicrobialactivityofwoundantisepticsandantibiotic AT karolinadydak thehighimpactofistaphylococcusaureusibiofilmculturemediumoninvitrooutcomesofantimicrobialactivityofwoundantisepticsandantibiotic AT monikaoleksywawrzyniak thehighimpactofistaphylococcusaureusibiofilmculturemediumoninvitrooutcomesofantimicrobialactivityofwoundantisepticsandantibiotic AT dariaciecholewskajusko thehighimpactofistaphylococcusaureusibiofilmculturemediumoninvitrooutcomesofantimicrobialactivityofwoundantisepticsandantibiotic AT ewelinadziedzic thehighimpactofistaphylococcusaureusibiofilmculturemediumoninvitrooutcomesofantimicrobialactivityofwoundantisepticsandantibiotic AT marzennabartoszewicz thehighimpactofistaphylococcusaureusibiofilmculturemediumoninvitrooutcomesofantimicrobialactivityofwoundantisepticsandantibiotic AT justynapaleczny highimpactofistaphylococcusaureusibiofilmculturemediumoninvitrooutcomesofantimicrobialactivityofwoundantisepticsandantibiotic AT adamjunka highimpactofistaphylococcusaureusibiofilmculturemediumoninvitrooutcomesofantimicrobialactivityofwoundantisepticsandantibiotic AT malwinabrozyna highimpactofistaphylococcusaureusibiofilmculturemediumoninvitrooutcomesofantimicrobialactivityofwoundantisepticsandantibiotic AT karolinadydak highimpactofistaphylococcusaureusibiofilmculturemediumoninvitrooutcomesofantimicrobialactivityofwoundantisepticsandantibiotic AT monikaoleksywawrzyniak highimpactofistaphylococcusaureusibiofilmculturemediumoninvitrooutcomesofantimicrobialactivityofwoundantisepticsandantibiotic AT dariaciecholewskajusko highimpactofistaphylococcusaureusibiofilmculturemediumoninvitrooutcomesofantimicrobialactivityofwoundantisepticsandantibiotic AT ewelinadziedzic highimpactofistaphylococcusaureusibiofilmculturemediumoninvitrooutcomesofantimicrobialactivityofwoundantisepticsandantibiotic AT marzennabartoszewicz highimpactofistaphylococcusaureusibiofilmculturemediumoninvitrooutcomesofantimicrobialactivityofwoundantisepticsandantibiotic
_version_	1718410886534660096

The High Impact of <i>Staphylococcus aureus</i> Biofilm Culture Medium on In Vitro Outcomes of Antimicrobial Activity of Wound Antiseptics and Antibiotic

Ejemplares similares