Unveiling the neuromechanical mechanisms underlying the synergistic interactions in human sensorimotor system

Abstract Motor synergies are neural organizations of a set of redundant motor effectors that interact with one another to compensate for each other’s error and ensure the stabilization of a performance variable. Recent studies have demonstrated that central nervous system synergistically coordinates...

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Autores principales:	S. Honarvar, C. Kim, Y. Diaz-Mercado, K. Koh, H. J. Kwon, T. Kiemel, M. Caminita, J. O. Hahn, J. K. Shim
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/392b63832b494bbaa9eed49b8d8e4981
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id	oai:doaj.org-article:392b63832b494bbaa9eed49b8d8e4981
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spelling	oai:doaj.org-article:392b63832b494bbaa9eed49b8d8e49812021-12-02T15:08:23ZUnveiling the neuromechanical mechanisms underlying the synergistic interactions in human sensorimotor system10.1038/s41598-020-80420-z2045-2322https://doaj.org/article/392b63832b494bbaa9eed49b8d8e49812021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-80420-zhttps://doaj.org/toc/2045-2322Abstract Motor synergies are neural organizations of a set of redundant motor effectors that interact with one another to compensate for each other’s error and ensure the stabilization of a performance variable. Recent studies have demonstrated that central nervous system synergistically coordinates its numerous motor effectors through Bayesian multi-sensory integration. Deficiency in sensory synergy weakens the synergistic interaction between the motor effectors. Here, we scrutinize the neuromechanical mechanism underlying this phenomenon through spectral analysis and modeling. We validate our model-generated results using experimental data reported in the literature collected from participants performing a finger force production task with and without tactile feedback (manipulated through injection of anesthetic in fingers). Spectral analysis reveals that the error compensation feature of synergies occurs only at low frequencies. Modeling suggests that the neurophysiological structures involving short-latency back-coupling loops similar to the well-known Renshaw cells explain the deterioration of synergy due to sensory deprivation.S. HonarvarC. KimY. Diaz-MercadoK. KohH. J. KwonT. KiemelM. CaminitaJ. O. HahnJ. K. ShimNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q S. Honarvar C. Kim Y. Diaz-Mercado K. Koh H. J. Kwon T. Kiemel M. Caminita J. O. Hahn J. K. Shim Unveiling the neuromechanical mechanisms underlying the synergistic interactions in human sensorimotor system
description	Abstract Motor synergies are neural organizations of a set of redundant motor effectors that interact with one another to compensate for each other’s error and ensure the stabilization of a performance variable. Recent studies have demonstrated that central nervous system synergistically coordinates its numerous motor effectors through Bayesian multi-sensory integration. Deficiency in sensory synergy weakens the synergistic interaction between the motor effectors. Here, we scrutinize the neuromechanical mechanism underlying this phenomenon through spectral analysis and modeling. We validate our model-generated results using experimental data reported in the literature collected from participants performing a finger force production task with and without tactile feedback (manipulated through injection of anesthetic in fingers). Spectral analysis reveals that the error compensation feature of synergies occurs only at low frequencies. Modeling suggests that the neurophysiological structures involving short-latency back-coupling loops similar to the well-known Renshaw cells explain the deterioration of synergy due to sensory deprivation.
format	article
author	S. Honarvar C. Kim Y. Diaz-Mercado K. Koh H. J. Kwon T. Kiemel M. Caminita J. O. Hahn J. K. Shim
author_facet	S. Honarvar C. Kim Y. Diaz-Mercado K. Koh H. J. Kwon T. Kiemel M. Caminita J. O. Hahn J. K. Shim
author_sort	S. Honarvar
title	Unveiling the neuromechanical mechanisms underlying the synergistic interactions in human sensorimotor system
title_short	Unveiling the neuromechanical mechanisms underlying the synergistic interactions in human sensorimotor system
title_full	Unveiling the neuromechanical mechanisms underlying the synergistic interactions in human sensorimotor system
title_fullStr	Unveiling the neuromechanical mechanisms underlying the synergistic interactions in human sensorimotor system
title_full_unstemmed	Unveiling the neuromechanical mechanisms underlying the synergistic interactions in human sensorimotor system
title_sort	unveiling the neuromechanical mechanisms underlying the synergistic interactions in human sensorimotor system
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/392b63832b494bbaa9eed49b8d8e4981
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Unveiling the neuromechanical mechanisms underlying the synergistic interactions in human sensorimotor system

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