p16Ink4a and p21Cip1/Waf1 promote tumour growth by enhancing myeloid-derived suppressor cells chemotaxis

Both p16Ink4a and p21Cip1/Waf1 are known oncosuppressors and have a role in senescence. Here, the authors show a pro-tumorigenic role for these two proteins: high expression in myeloid-derived suppressor cells stimulates their chemotactic function, favouring tumour progression.

Guardado en:

Detalles Bibliográficos
Autores principales:	Atsushi Okuma, Aki Hanyu, Sugiko Watanabe, Eiji Hara
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/392be485396f4baba3edd082b4c5ecbf
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:392be485396f4baba3edd082b4c5ecbf
record_format	dspace
spelling	oai:doaj.org-article:392be485396f4baba3edd082b4c5ecbf2021-12-02T15:37:01Zp16Ink4a and p21Cip1/Waf1 promote tumour growth by enhancing myeloid-derived suppressor cells chemotaxis10.1038/s41467-017-02281-x2041-1723https://doaj.org/article/392be485396f4baba3edd082b4c5ecbf2017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02281-xhttps://doaj.org/toc/2041-1723Both p16Ink4a and p21Cip1/Waf1 are known oncosuppressors and have a role in senescence. Here, the authors show a pro-tumorigenic role for these two proteins: high expression in myeloid-derived suppressor cells stimulates their chemotactic function, favouring tumour progression.Atsushi OkumaAki HanyuSugiko WatanabeEiji HaraNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Atsushi Okuma Aki Hanyu Sugiko Watanabe Eiji Hara p16Ink4a and p21Cip1/Waf1 promote tumour growth by enhancing myeloid-derived suppressor cells chemotaxis
description	Both p16Ink4a and p21Cip1/Waf1 are known oncosuppressors and have a role in senescence. Here, the authors show a pro-tumorigenic role for these two proteins: high expression in myeloid-derived suppressor cells stimulates their chemotactic function, favouring tumour progression.
format	article
author	Atsushi Okuma Aki Hanyu Sugiko Watanabe Eiji Hara
author_facet	Atsushi Okuma Aki Hanyu Sugiko Watanabe Eiji Hara
author_sort	Atsushi Okuma
title	p16Ink4a and p21Cip1/Waf1 promote tumour growth by enhancing myeloid-derived suppressor cells chemotaxis
title_short	p16Ink4a and p21Cip1/Waf1 promote tumour growth by enhancing myeloid-derived suppressor cells chemotaxis
title_full	p16Ink4a and p21Cip1/Waf1 promote tumour growth by enhancing myeloid-derived suppressor cells chemotaxis
title_fullStr	p16Ink4a and p21Cip1/Waf1 promote tumour growth by enhancing myeloid-derived suppressor cells chemotaxis
title_full_unstemmed	p16Ink4a and p21Cip1/Waf1 promote tumour growth by enhancing myeloid-derived suppressor cells chemotaxis
title_sort	p16ink4a and p21cip1/waf1 promote tumour growth by enhancing myeloid-derived suppressor cells chemotaxis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/392be485396f4baba3edd082b4c5ecbf
work_keys_str_mv	AT atsushiokuma p16ink4aandp21cip1waf1promotetumourgrowthbyenhancingmyeloidderivedsuppressorcellschemotaxis AT akihanyu p16ink4aandp21cip1waf1promotetumourgrowthbyenhancingmyeloidderivedsuppressorcellschemotaxis AT sugikowatanabe p16ink4aandp21cip1waf1promotetumourgrowthbyenhancingmyeloidderivedsuppressorcellschemotaxis AT eijihara p16ink4aandp21cip1waf1promotetumourgrowthbyenhancingmyeloidderivedsuppressorcellschemotaxis
_version_	1718386283847352320

p16Ink4a and p21Cip1/Waf1 promote tumour growth by enhancing myeloid-derived suppressor cells chemotaxis

Ejemplares similares