Biological and epidemiological evidence of anti-allergic effects of traditional Japanese food ume (Prunus mume)

Abstract Japanese apricot (Prunus mume; ume) is a traditional food in Japan that has been shown to have various beneficial health effects. There is some evidence to suggest that ume is also effective against allergic disease. Here, we conducted a cross-sectional epidemiological pilot study to examin...

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Autores principales:	Ryohei Kono, Misa Nakamura, Sachiko Nomura, Naomi Kitano, Tomoko Kagiya, Yoshiharu Okuno, Ken-ichi Inada, Akihiko Tokuda, Hirotoshi Utsunomiya, Masami Ueno
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/392f8dc5541e40768af6f4d16b863e58
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spelling	oai:doaj.org-article:392f8dc5541e40768af6f4d16b863e582021-12-02T15:08:25ZBiological and epidemiological evidence of anti-allergic effects of traditional Japanese food ume (Prunus mume)10.1038/s41598-018-30086-52045-2322https://doaj.org/article/392f8dc5541e40768af6f4d16b863e582018-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-30086-5https://doaj.org/toc/2045-2322Abstract Japanese apricot (Prunus mume; ume) is a traditional food in Japan that has been shown to have various beneficial health effects. There is some evidence to suggest that ume is also effective against allergic disease. Here, we conducted a cross-sectional epidemiological pilot study to examine the association between ume intake frequency and allergic symptoms including rhinitis in 563 adults (288 men and 275 women) who resided in Wakayama, Japan. After adjusting for age, present illness and medication, women with high ume intake had significantly lower odds ratio (OR) for the presence of symptoms of allergy [OR: 0.49 with 95% confidence interval (CI): 0.25–0.97]. Therefore, we investigated the anti-allergic effect of ume on passive cutaneous anaphylaxis (PCA) reaction in immunoglobulin E (IgE)-sensitized mice. The animal study demonstrated that oral administration of ume extract attenuated the PCA reaction and mast cell degranulation. Furthermore, RBL-2H3 mast cells were used to identify anti-allergic ume compounds. The following ume compounds inhibited IgE-mediated mast cell degranulation: vanillin, syringic acid, protocatechuic aldehyde, lyoniresinol and p-coumaric acid. These results suggested that ume has the potential to inhibit mast cell degranulation and may be associated with reduced risk of allergic symptoms in women.Ryohei KonoMisa NakamuraSachiko NomuraNaomi KitanoTomoko KagiyaYoshiharu OkunoKen-ichi InadaAkihiko TokudaHirotoshi UtsunomiyaMasami UenoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ryohei Kono Misa Nakamura Sachiko Nomura Naomi Kitano Tomoko Kagiya Yoshiharu Okuno Ken-ichi Inada Akihiko Tokuda Hirotoshi Utsunomiya Masami Ueno Biological and epidemiological evidence of anti-allergic effects of traditional Japanese food ume (Prunus mume)
description	Abstract Japanese apricot (Prunus mume; ume) is a traditional food in Japan that has been shown to have various beneficial health effects. There is some evidence to suggest that ume is also effective against allergic disease. Here, we conducted a cross-sectional epidemiological pilot study to examine the association between ume intake frequency and allergic symptoms including rhinitis in 563 adults (288 men and 275 women) who resided in Wakayama, Japan. After adjusting for age, present illness and medication, women with high ume intake had significantly lower odds ratio (OR) for the presence of symptoms of allergy [OR: 0.49 with 95% confidence interval (CI): 0.25–0.97]. Therefore, we investigated the anti-allergic effect of ume on passive cutaneous anaphylaxis (PCA) reaction in immunoglobulin E (IgE)-sensitized mice. The animal study demonstrated that oral administration of ume extract attenuated the PCA reaction and mast cell degranulation. Furthermore, RBL-2H3 mast cells were used to identify anti-allergic ume compounds. The following ume compounds inhibited IgE-mediated mast cell degranulation: vanillin, syringic acid, protocatechuic aldehyde, lyoniresinol and p-coumaric acid. These results suggested that ume has the potential to inhibit mast cell degranulation and may be associated with reduced risk of allergic symptoms in women.
format	article
author	Ryohei Kono Misa Nakamura Sachiko Nomura Naomi Kitano Tomoko Kagiya Yoshiharu Okuno Ken-ichi Inada Akihiko Tokuda Hirotoshi Utsunomiya Masami Ueno
author_facet	Ryohei Kono Misa Nakamura Sachiko Nomura Naomi Kitano Tomoko Kagiya Yoshiharu Okuno Ken-ichi Inada Akihiko Tokuda Hirotoshi Utsunomiya Masami Ueno
author_sort	Ryohei Kono
title	Biological and epidemiological evidence of anti-allergic effects of traditional Japanese food ume (Prunus mume)
title_short	Biological and epidemiological evidence of anti-allergic effects of traditional Japanese food ume (Prunus mume)
title_full	Biological and epidemiological evidence of anti-allergic effects of traditional Japanese food ume (Prunus mume)
title_fullStr	Biological and epidemiological evidence of anti-allergic effects of traditional Japanese food ume (Prunus mume)
title_full_unstemmed	Biological and epidemiological evidence of anti-allergic effects of traditional Japanese food ume (Prunus mume)
title_sort	biological and epidemiological evidence of anti-allergic effects of traditional japanese food ume (prunus mume)
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/392f8dc5541e40768af6f4d16b863e58
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Biological and epidemiological evidence of anti-allergic effects of traditional Japanese food ume (Prunus mume)

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