Comparison of choroidal neovascularization secondary to white dot syndromes and age-related macular degeneration by using optical coherence tomography angiography

Jay C Wang, Kenneth M McKay, Arjun B Sood, Inês Laíns, Lucia Sobrin, John B Miller Retina Service, Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA 02114, USA Purpose: To characterize and compare choroidal neovascularization (CNV) seco...

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Autores principales:	Wang JC, McKay KM, Sood AB, Laíns I, Sobrin L, Miller JB
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	white dot syndromes age-related macular degeneration choroidal neovascularization optical coherence tomography angiography Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/39306bbc5bc6491eb82717d1dbff1a47
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spelling	oai:doaj.org-article:39306bbc5bc6491eb82717d1dbff1a472021-12-02T04:11:20ZComparison of choroidal neovascularization secondary to white dot syndromes and age-related macular degeneration by using optical coherence tomography angiography1177-5483https://doaj.org/article/39306bbc5bc6491eb82717d1dbff1a472018-12-01T00:00:00Zhttps://www.dovepress.com/comparison-of-choroidal-neovascularization-secondary-to-white-dot-synd-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Jay C Wang, Kenneth M McKay, Arjun B Sood, Inês Laíns, Lucia Sobrin, John B Miller Retina Service, Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA 02114, USA Purpose: To characterize and compare choroidal neovascularization (CNV) secondary to white dot syndromes (WDS) and age-related macular degeneration (AMD) using optical coherence tomography angiography (OCT-A).Methods: This is a cross-sectional study in which we imaged patients with CNV secondary to WDS and AMD with either the Zeiss Angioplex OCT-A or Optovue AngioVue OCT-A. Relevant demographic and clinical characteristics were collected and analyzed. CNV area and vessel density (VD) were measured by three independent graders, and linear regression analysis was subsequently performed.Results: Three patients with multifocal choroiditis and panuveitis, one patient each with birdshot chorioretinopathy, presumed ocular histoplasmosis syndrome, and persistent placoid maculopathy, and eleven patients with AMD with sufficient image quality were included. CNV associated with WDS was significantly smaller than that secondary to AMD (0.56±0.32 vs 2.79±1.80 mm2, β=-2.22, P=0.01), while no difference in VD was detected (0.46±0.09 vs 0.44±0.09, β=0.02, P=0.71).Conclusion: CNV networks secondary to WDS appear to be smaller than those secondary to AMD but have similar VD. OCT-A is a powerful tool to investigate properties of CNV from various etiologies. Larger studies are needed for further characterization and understanding of CNV pathogenesis in inflammatory conditions. Keywords: white dot syndromes, age-related macular degeneration, choroidal neovascularization, optical coherence tomography angiography, uveitis, inflammation, choroidal neovascular membraneWang JCMcKay KMSood ABLaíns ISobrin LMiller JBDove Medical Pressarticlewhite dot syndromesage-related macular degenerationchoroidal neovascularizationoptical coherence tomography angiographyOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 13, Pp 95-105 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	white dot syndromes age-related macular degeneration choroidal neovascularization optical coherence tomography angiography Ophthalmology RE1-994
spellingShingle	white dot syndromes age-related macular degeneration choroidal neovascularization optical coherence tomography angiography Ophthalmology RE1-994 Wang JC McKay KM Sood AB Laíns I Sobrin L Miller JB Comparison of choroidal neovascularization secondary to white dot syndromes and age-related macular degeneration by using optical coherence tomography angiography
description	Jay C Wang, Kenneth M McKay, Arjun B Sood, Inês Laíns, Lucia Sobrin, John B Miller Retina Service, Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA 02114, USA Purpose: To characterize and compare choroidal neovascularization (CNV) secondary to white dot syndromes (WDS) and age-related macular degeneration (AMD) using optical coherence tomography angiography (OCT-A).Methods: This is a cross-sectional study in which we imaged patients with CNV secondary to WDS and AMD with either the Zeiss Angioplex OCT-A or Optovue AngioVue OCT-A. Relevant demographic and clinical characteristics were collected and analyzed. CNV area and vessel density (VD) were measured by three independent graders, and linear regression analysis was subsequently performed.Results: Three patients with multifocal choroiditis and panuveitis, one patient each with birdshot chorioretinopathy, presumed ocular histoplasmosis syndrome, and persistent placoid maculopathy, and eleven patients with AMD with sufficient image quality were included. CNV associated with WDS was significantly smaller than that secondary to AMD (0.56±0.32 vs 2.79±1.80 mm2, β=-2.22, P=0.01), while no difference in VD was detected (0.46±0.09 vs 0.44±0.09, β=0.02, P=0.71).Conclusion: CNV networks secondary to WDS appear to be smaller than those secondary to AMD but have similar VD. OCT-A is a powerful tool to investigate properties of CNV from various etiologies. Larger studies are needed for further characterization and understanding of CNV pathogenesis in inflammatory conditions. Keywords: white dot syndromes, age-related macular degeneration, choroidal neovascularization, optical coherence tomography angiography, uveitis, inflammation, choroidal neovascular membrane
format	article
author	Wang JC McKay KM Sood AB Laíns I Sobrin L Miller JB
author_facet	Wang JC McKay KM Sood AB Laíns I Sobrin L Miller JB
author_sort	Wang JC
title	Comparison of choroidal neovascularization secondary to white dot syndromes and age-related macular degeneration by using optical coherence tomography angiography
title_short	Comparison of choroidal neovascularization secondary to white dot syndromes and age-related macular degeneration by using optical coherence tomography angiography
title_full	Comparison of choroidal neovascularization secondary to white dot syndromes and age-related macular degeneration by using optical coherence tomography angiography
title_fullStr	Comparison of choroidal neovascularization secondary to white dot syndromes and age-related macular degeneration by using optical coherence tomography angiography
title_full_unstemmed	Comparison of choroidal neovascularization secondary to white dot syndromes and age-related macular degeneration by using optical coherence tomography angiography
title_sort	comparison of choroidal neovascularization secondary to white dot syndromes and age-related macular degeneration by using optical coherence tomography angiography
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/39306bbc5bc6491eb82717d1dbff1a47
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Comparison of choroidal neovascularization secondary to white dot syndromes and age-related macular degeneration by using optical coherence tomography angiography

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