Quantitative assessment of protein activity in orphan tissues and single cells using the metaVIPER algorithm

VIPER has been successfully used to assess the regulatory activities of proteins from gene expression data, but its dependence on tissue-specific molecular profiles limits its applicability. MetaVIPER, introduced here, enables inference of the protein activities in orphan tissues and single cells.

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Detalles Bibliográficos
Autores principales: Hongxu Ding, Eugene F. Douglass, Adam M. Sonabend, Angeliki Mela, Sayantan Bose, Christian Gonzalez, Peter D. Canoll, Peter A. Sims, Mariano J. Alvarez, Andrea Califano
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/3934038bb326419f98860258816b7ced
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Sumario:VIPER has been successfully used to assess the regulatory activities of proteins from gene expression data, but its dependence on tissue-specific molecular profiles limits its applicability. MetaVIPER, introduced here, enables inference of the protein activities in orphan tissues and single cells.