Quantitative assessment of protein activity in orphan tissues and single cells using the metaVIPER algorithm

VIPER has been successfully used to assess the regulatory activities of proteins from gene expression data, but its dependence on tissue-specific molecular profiles limits its applicability. MetaVIPER, introduced here, enables inference of the protein activities in orphan tissues and single cells.

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Autores principales:	Hongxu Ding, Eugene F. Douglass, Adam M. Sonabend, Angeliki Mela, Sayantan Bose, Christian Gonzalez, Peter D. Canoll, Peter A. Sims, Mariano J. Alvarez, Andrea Califano
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3934038bb326419f98860258816b7ced
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spelling	oai:doaj.org-article:3934038bb326419f98860258816b7ced2021-12-02T16:49:18ZQuantitative assessment of protein activity in orphan tissues and single cells using the metaVIPER algorithm10.1038/s41467-018-03843-32041-1723https://doaj.org/article/3934038bb326419f98860258816b7ced2018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03843-3https://doaj.org/toc/2041-1723VIPER has been successfully used to assess the regulatory activities of proteins from gene expression data, but its dependence on tissue-specific molecular profiles limits its applicability. MetaVIPER, introduced here, enables inference of the protein activities in orphan tissues and single cells.Hongxu DingEugene F. DouglassAdam M. SonabendAngeliki MelaSayantan BoseChristian GonzalezPeter D. CanollPeter A. SimsMariano J. AlvarezAndrea CalifanoNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hongxu Ding Eugene F. Douglass Adam M. Sonabend Angeliki Mela Sayantan Bose Christian Gonzalez Peter D. Canoll Peter A. Sims Mariano J. Alvarez Andrea Califano Quantitative assessment of protein activity in orphan tissues and single cells using the metaVIPER algorithm
description	VIPER has been successfully used to assess the regulatory activities of proteins from gene expression data, but its dependence on tissue-specific molecular profiles limits its applicability. MetaVIPER, introduced here, enables inference of the protein activities in orphan tissues and single cells.
format	article
author	Hongxu Ding Eugene F. Douglass Adam M. Sonabend Angeliki Mela Sayantan Bose Christian Gonzalez Peter D. Canoll Peter A. Sims Mariano J. Alvarez Andrea Califano
author_facet	Hongxu Ding Eugene F. Douglass Adam M. Sonabend Angeliki Mela Sayantan Bose Christian Gonzalez Peter D. Canoll Peter A. Sims Mariano J. Alvarez Andrea Califano
author_sort	Hongxu Ding
title	Quantitative assessment of protein activity in orphan tissues and single cells using the metaVIPER algorithm
title_short	Quantitative assessment of protein activity in orphan tissues and single cells using the metaVIPER algorithm
title_full	Quantitative assessment of protein activity in orphan tissues and single cells using the metaVIPER algorithm
title_fullStr	Quantitative assessment of protein activity in orphan tissues and single cells using the metaVIPER algorithm
title_full_unstemmed	Quantitative assessment of protein activity in orphan tissues and single cells using the metaVIPER algorithm
title_sort	quantitative assessment of protein activity in orphan tissues and single cells using the metaviper algorithm
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/3934038bb326419f98860258816b7ced
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Quantitative assessment of protein activity in orphan tissues and single cells using the metaVIPER algorithm

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