Introduction of neutralizing immunogenicity index to the rational design of MERS coronavirus subunit vaccines

Viral subunit vaccines contain epitopes that elicit non-neutralizing immune responses. Here, Duet al. mask an immunodominant non-neutralizing epitope on a MERS coronavirus subunit vaccine with a glycan probe, leading to significantly improved efficacy of the vaccine.

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Autores principales:	Lanying Du, Wanbo Tai, Yang Yang, Guangyu Zhao, Qing Zhu, Shihui Sun, Chang Liu, Xinrong Tao, Chien-Te K. Tseng, Stanley Perlman, Shibo Jiang, Yusen Zhou, Fang Li
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3934f045fa854cd7953df8a4748d42cb
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spelling	oai:doaj.org-article:3934f045fa854cd7953df8a4748d42cb2021-12-02T17:32:08ZIntroduction of neutralizing immunogenicity index to the rational design of MERS coronavirus subunit vaccines10.1038/ncomms134732041-1723https://doaj.org/article/3934f045fa854cd7953df8a4748d42cb2016-11-01T00:00:00Zhttps://doi.org/10.1038/ncomms13473https://doaj.org/toc/2041-1723Viral subunit vaccines contain epitopes that elicit non-neutralizing immune responses. Here, Duet al. mask an immunodominant non-neutralizing epitope on a MERS coronavirus subunit vaccine with a glycan probe, leading to significantly improved efficacy of the vaccine.Lanying DuWanbo TaiYang YangGuangyu ZhaoQing ZhuShihui SunChang LiuXinrong TaoChien-Te K. TsengStanley PerlmanShibo JiangYusen ZhouFang LiNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lanying Du Wanbo Tai Yang Yang Guangyu Zhao Qing Zhu Shihui Sun Chang Liu Xinrong Tao Chien-Te K. Tseng Stanley Perlman Shibo Jiang Yusen Zhou Fang Li Introduction of neutralizing immunogenicity index to the rational design of MERS coronavirus subunit vaccines
description	Viral subunit vaccines contain epitopes that elicit non-neutralizing immune responses. Here, Duet al. mask an immunodominant non-neutralizing epitope on a MERS coronavirus subunit vaccine with a glycan probe, leading to significantly improved efficacy of the vaccine.
format	article
author	Lanying Du Wanbo Tai Yang Yang Guangyu Zhao Qing Zhu Shihui Sun Chang Liu Xinrong Tao Chien-Te K. Tseng Stanley Perlman Shibo Jiang Yusen Zhou Fang Li
author_facet	Lanying Du Wanbo Tai Yang Yang Guangyu Zhao Qing Zhu Shihui Sun Chang Liu Xinrong Tao Chien-Te K. Tseng Stanley Perlman Shibo Jiang Yusen Zhou Fang Li
author_sort	Lanying Du
title	Introduction of neutralizing immunogenicity index to the rational design of MERS coronavirus subunit vaccines
title_short	Introduction of neutralizing immunogenicity index to the rational design of MERS coronavirus subunit vaccines
title_full	Introduction of neutralizing immunogenicity index to the rational design of MERS coronavirus subunit vaccines
title_fullStr	Introduction of neutralizing immunogenicity index to the rational design of MERS coronavirus subunit vaccines
title_full_unstemmed	Introduction of neutralizing immunogenicity index to the rational design of MERS coronavirus subunit vaccines
title_sort	introduction of neutralizing immunogenicity index to the rational design of mers coronavirus subunit vaccines
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/3934f045fa854cd7953df8a4748d42cb
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Introduction of neutralizing immunogenicity index to the rational design of MERS coronavirus subunit vaccines

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