Stromal Hedgehog signalling is downregulated in colon cancer and its restoration restrains tumour growth
The Hedgehog signalling pathway can drive tumorigenesis. Here, the authors show that in a colitis-associated colon cancer model downstream Hedgehog signalling is restricted to the stroma and its over-activation can inhibit tumorigenesis, associated with activation of BMP signaling.
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Nature Portfolio
2016
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oai:doaj.org-article:3935658324894f5a9a9d4187bc7ac9492021-12-02T15:34:33ZStromal Hedgehog signalling is downregulated in colon cancer and its restoration restrains tumour growth10.1038/ncomms123212041-1723https://doaj.org/article/3935658324894f5a9a9d4187bc7ac9492016-08-01T00:00:00Zhttps://doi.org/10.1038/ncomms12321https://doaj.org/toc/2041-1723The Hedgehog signalling pathway can drive tumorigenesis. Here, the authors show that in a colitis-associated colon cancer model downstream Hedgehog signalling is restricted to the stroma and its over-activation can inhibit tumorigenesis, associated with activation of BMP signaling.Marco GerlingNikè V. J. A. BüllerLeonard M. KirnSimon JoostOliver FringsBenjamin EnglertÅsa BergströmRaoul V. KuiperLeander BlaasMattheus C. B. WielengaSven AlmerAnja A. KühlErik FredlundGijs R. van den BrinkRune ToftgårdNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-17 (2016) |
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Science Q Marco Gerling Nikè V. J. A. Büller Leonard M. Kirn Simon Joost Oliver Frings Benjamin Englert Åsa Bergström Raoul V. Kuiper Leander Blaas Mattheus C. B. Wielenga Sven Almer Anja A. Kühl Erik Fredlund Gijs R. van den Brink Rune Toftgård Stromal Hedgehog signalling is downregulated in colon cancer and its restoration restrains tumour growth |
description |
The Hedgehog signalling pathway can drive tumorigenesis. Here, the authors show that in a colitis-associated colon cancer model downstream Hedgehog signalling is restricted to the stroma and its over-activation can inhibit tumorigenesis, associated with activation of BMP signaling. |
format |
article |
author |
Marco Gerling Nikè V. J. A. Büller Leonard M. Kirn Simon Joost Oliver Frings Benjamin Englert Åsa Bergström Raoul V. Kuiper Leander Blaas Mattheus C. B. Wielenga Sven Almer Anja A. Kühl Erik Fredlund Gijs R. van den Brink Rune Toftgård |
author_facet |
Marco Gerling Nikè V. J. A. Büller Leonard M. Kirn Simon Joost Oliver Frings Benjamin Englert Åsa Bergström Raoul V. Kuiper Leander Blaas Mattheus C. B. Wielenga Sven Almer Anja A. Kühl Erik Fredlund Gijs R. van den Brink Rune Toftgård |
author_sort |
Marco Gerling |
title |
Stromal Hedgehog signalling is downregulated in colon cancer and its restoration restrains tumour growth |
title_short |
Stromal Hedgehog signalling is downregulated in colon cancer and its restoration restrains tumour growth |
title_full |
Stromal Hedgehog signalling is downregulated in colon cancer and its restoration restrains tumour growth |
title_fullStr |
Stromal Hedgehog signalling is downregulated in colon cancer and its restoration restrains tumour growth |
title_full_unstemmed |
Stromal Hedgehog signalling is downregulated in colon cancer and its restoration restrains tumour growth |
title_sort |
stromal hedgehog signalling is downregulated in colon cancer and its restoration restrains tumour growth |
publisher |
Nature Portfolio |
publishDate |
2016 |
url |
https://doaj.org/article/3935658324894f5a9a9d4187bc7ac949 |
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