Stromal Hedgehog signalling is downregulated in colon cancer and its restoration restrains tumour growth

The Hedgehog signalling pathway can drive tumorigenesis. Here, the authors show that in a colitis-associated colon cancer model downstream Hedgehog signalling is restricted to the stroma and its over-activation can inhibit tumorigenesis, associated with activation of BMP signaling.

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Autores principales: Marco Gerling, Nikè V. J. A. Büller, Leonard M. Kirn, Simon Joost, Oliver Frings, Benjamin Englert, Åsa Bergström, Raoul V. Kuiper, Leander Blaas, Mattheus C. B. Wielenga, Sven Almer, Anja A. Kühl, Erik Fredlund, Gijs R. van den Brink, Rune Toftgård
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Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/3935658324894f5a9a9d4187bc7ac949
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spelling oai:doaj.org-article:3935658324894f5a9a9d4187bc7ac9492021-12-02T15:34:33ZStromal Hedgehog signalling is downregulated in colon cancer and its restoration restrains tumour growth10.1038/ncomms123212041-1723https://doaj.org/article/3935658324894f5a9a9d4187bc7ac9492016-08-01T00:00:00Zhttps://doi.org/10.1038/ncomms12321https://doaj.org/toc/2041-1723The Hedgehog signalling pathway can drive tumorigenesis. Here, the authors show that in a colitis-associated colon cancer model downstream Hedgehog signalling is restricted to the stroma and its over-activation can inhibit tumorigenesis, associated with activation of BMP signaling.Marco GerlingNikè V. J. A. BüllerLeonard M. KirnSimon JoostOliver FringsBenjamin EnglertÅsa BergströmRaoul V. KuiperLeander BlaasMattheus C. B. WielengaSven AlmerAnja A. KühlErik FredlundGijs R. van den BrinkRune ToftgårdNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-17 (2016)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Marco Gerling
Nikè V. J. A. Büller
Leonard M. Kirn
Simon Joost
Oliver Frings
Benjamin Englert
Åsa Bergström
Raoul V. Kuiper
Leander Blaas
Mattheus C. B. Wielenga
Sven Almer
Anja A. Kühl
Erik Fredlund
Gijs R. van den Brink
Rune Toftgård
Stromal Hedgehog signalling is downregulated in colon cancer and its restoration restrains tumour growth
description The Hedgehog signalling pathway can drive tumorigenesis. Here, the authors show that in a colitis-associated colon cancer model downstream Hedgehog signalling is restricted to the stroma and its over-activation can inhibit tumorigenesis, associated with activation of BMP signaling.
format article
author Marco Gerling
Nikè V. J. A. Büller
Leonard M. Kirn
Simon Joost
Oliver Frings
Benjamin Englert
Åsa Bergström
Raoul V. Kuiper
Leander Blaas
Mattheus C. B. Wielenga
Sven Almer
Anja A. Kühl
Erik Fredlund
Gijs R. van den Brink
Rune Toftgård
author_facet Marco Gerling
Nikè V. J. A. Büller
Leonard M. Kirn
Simon Joost
Oliver Frings
Benjamin Englert
Åsa Bergström
Raoul V. Kuiper
Leander Blaas
Mattheus C. B. Wielenga
Sven Almer
Anja A. Kühl
Erik Fredlund
Gijs R. van den Brink
Rune Toftgård
author_sort Marco Gerling
title Stromal Hedgehog signalling is downregulated in colon cancer and its restoration restrains tumour growth
title_short Stromal Hedgehog signalling is downregulated in colon cancer and its restoration restrains tumour growth
title_full Stromal Hedgehog signalling is downregulated in colon cancer and its restoration restrains tumour growth
title_fullStr Stromal Hedgehog signalling is downregulated in colon cancer and its restoration restrains tumour growth
title_full_unstemmed Stromal Hedgehog signalling is downregulated in colon cancer and its restoration restrains tumour growth
title_sort stromal hedgehog signalling is downregulated in colon cancer and its restoration restrains tumour growth
publisher Nature Portfolio
publishDate 2016
url https://doaj.org/article/3935658324894f5a9a9d4187bc7ac949
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