Calcium Ions Aggravate Alzheimer’s Disease Through the Aberrant Activation of Neuronal Networks, Leading to Synaptic and Cognitive Deficits

Alzheimer’s disease (AD) is a neurodegenerative disease that is characterized by the production and deposition of β-amyloid protein (Aβ) and hyperphosphorylated tau, leading to the formation of β-amyloid plaques (APs) and neurofibrillary tangles (NFTs). Although calcium ions (Ca2+) promote the forma...

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Autores principales:	Pei-Pei Guan, Long-Long Cao, Yi Yang, Pu Wang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	calcium ions transporters mechanisms Alzheimer’s disease review Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/39366b1cc2fb4b1fb6a4dd2b690d2606
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spelling	oai:doaj.org-article:39366b1cc2fb4b1fb6a4dd2b690d26062021-12-02T10:20:31ZCalcium Ions Aggravate Alzheimer’s Disease Through the Aberrant Activation of Neuronal Networks, Leading to Synaptic and Cognitive Deficits1662-509910.3389/fnmol.2021.757515https://doaj.org/article/39366b1cc2fb4b1fb6a4dd2b690d26062021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fnmol.2021.757515/fullhttps://doaj.org/toc/1662-5099Alzheimer’s disease (AD) is a neurodegenerative disease that is characterized by the production and deposition of β-amyloid protein (Aβ) and hyperphosphorylated tau, leading to the formation of β-amyloid plaques (APs) and neurofibrillary tangles (NFTs). Although calcium ions (Ca2+) promote the formation of APs and NFTs, no systematic review of the mechanisms by which Ca2+ affects the development and progression of AD has been published. Therefore, the current review aimed to fill the gaps between elevated Ca2+ levels and the pathogenesis of AD. Specifically, we mainly focus on the molecular mechanisms by which Ca2+ affects the neuronal networks of neuroinflammation, neuronal injury, neurogenesis, neurotoxicity, neuroprotection, and autophagy. Furthermore, the roles of Ca2+ transporters located in the cell membrane, endoplasmic reticulum (ER), mitochondria and lysosome in mediating the effects of Ca2+ on activating neuronal networks that ultimately contribute to the development and progression of AD are discussed. Finally, the drug candidates derived from herbs used as food or seasoning in Chinese daily life are summarized to provide a theoretical basis for improving the clinical treatment of AD.Pei-Pei GuanLong-Long CaoYi YangPu WangFrontiers Media S.A.articlecalcium ionstransportersmechanismsAlzheimer’s diseasereviewNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENFrontiers in Molecular Neuroscience, Vol 14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	calcium ions transporters mechanisms Alzheimer’s disease review Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	calcium ions transporters mechanisms Alzheimer’s disease review Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Pei-Pei Guan Long-Long Cao Yi Yang Pu Wang Calcium Ions Aggravate Alzheimer’s Disease Through the Aberrant Activation of Neuronal Networks, Leading to Synaptic and Cognitive Deficits
description	Alzheimer’s disease (AD) is a neurodegenerative disease that is characterized by the production and deposition of β-amyloid protein (Aβ) and hyperphosphorylated tau, leading to the formation of β-amyloid plaques (APs) and neurofibrillary tangles (NFTs). Although calcium ions (Ca2+) promote the formation of APs and NFTs, no systematic review of the mechanisms by which Ca2+ affects the development and progression of AD has been published. Therefore, the current review aimed to fill the gaps between elevated Ca2+ levels and the pathogenesis of AD. Specifically, we mainly focus on the molecular mechanisms by which Ca2+ affects the neuronal networks of neuroinflammation, neuronal injury, neurogenesis, neurotoxicity, neuroprotection, and autophagy. Furthermore, the roles of Ca2+ transporters located in the cell membrane, endoplasmic reticulum (ER), mitochondria and lysosome in mediating the effects of Ca2+ on activating neuronal networks that ultimately contribute to the development and progression of AD are discussed. Finally, the drug candidates derived from herbs used as food or seasoning in Chinese daily life are summarized to provide a theoretical basis for improving the clinical treatment of AD.
format	article
author	Pei-Pei Guan Long-Long Cao Yi Yang Pu Wang
author_facet	Pei-Pei Guan Long-Long Cao Yi Yang Pu Wang
author_sort	Pei-Pei Guan
title	Calcium Ions Aggravate Alzheimer’s Disease Through the Aberrant Activation of Neuronal Networks, Leading to Synaptic and Cognitive Deficits
title_short	Calcium Ions Aggravate Alzheimer’s Disease Through the Aberrant Activation of Neuronal Networks, Leading to Synaptic and Cognitive Deficits
title_full	Calcium Ions Aggravate Alzheimer’s Disease Through the Aberrant Activation of Neuronal Networks, Leading to Synaptic and Cognitive Deficits
title_fullStr	Calcium Ions Aggravate Alzheimer’s Disease Through the Aberrant Activation of Neuronal Networks, Leading to Synaptic and Cognitive Deficits
title_full_unstemmed	Calcium Ions Aggravate Alzheimer’s Disease Through the Aberrant Activation of Neuronal Networks, Leading to Synaptic and Cognitive Deficits
title_sort	calcium ions aggravate alzheimer’s disease through the aberrant activation of neuronal networks, leading to synaptic and cognitive deficits
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/39366b1cc2fb4b1fb6a4dd2b690d2606
work_keys_str_mv	AT peipeiguan calciumionsaggravatealzheimersdiseasethroughtheaberrantactivationofneuronalnetworksleadingtosynapticandcognitivedeficits AT longlongcao calciumionsaggravatealzheimersdiseasethroughtheaberrantactivationofneuronalnetworksleadingtosynapticandcognitivedeficits AT yiyang calciumionsaggravatealzheimersdiseasethroughtheaberrantactivationofneuronalnetworksleadingtosynapticandcognitivedeficits AT puwang calciumionsaggravatealzheimersdiseasethroughtheaberrantactivationofneuronalnetworksleadingtosynapticandcognitivedeficits
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Calcium Ions Aggravate Alzheimer’s Disease Through the Aberrant Activation of Neuronal Networks, Leading to Synaptic and Cognitive Deficits

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