NMDAR-mediated modulation of gap junction circuit regulates olfactory learning in C. elegans

Neural plasticity underlies learning and is regulated by modulation of gap junctions. Here, the authors show that NMDAR- and CaMKII-mediated cell autonomous downregulation of gap junction molecules in a circuit of interneurons facilitates olfactory learning affecting behavior in C. elegans.

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Autores principales:	Myung-Kyu Choi, He Liu, Taihong Wu, Wenxing Yang, Yun Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/39398b289a3b4e4591f7870378ecd1af
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spelling	oai:doaj.org-article:39398b289a3b4e4591f7870378ecd1af2021-12-02T15:23:00ZNMDAR-mediated modulation of gap junction circuit regulates olfactory learning in C. elegans10.1038/s41467-020-17218-02041-1723https://doaj.org/article/39398b289a3b4e4591f7870378ecd1af2020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17218-0https://doaj.org/toc/2041-1723Neural plasticity underlies learning and is regulated by modulation of gap junctions. Here, the authors show that NMDAR- and CaMKII-mediated cell autonomous downregulation of gap junction molecules in a circuit of interneurons facilitates olfactory learning affecting behavior in C. elegans.Myung-Kyu ChoiHe LiuTaihong WuWenxing YangYun ZhangNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Myung-Kyu Choi He Liu Taihong Wu Wenxing Yang Yun Zhang NMDAR-mediated modulation of gap junction circuit regulates olfactory learning in C. elegans
description	Neural plasticity underlies learning and is regulated by modulation of gap junctions. Here, the authors show that NMDAR- and CaMKII-mediated cell autonomous downregulation of gap junction molecules in a circuit of interneurons facilitates olfactory learning affecting behavior in C. elegans.
format	article
author	Myung-Kyu Choi He Liu Taihong Wu Wenxing Yang Yun Zhang
author_facet	Myung-Kyu Choi He Liu Taihong Wu Wenxing Yang Yun Zhang
author_sort	Myung-Kyu Choi
title	NMDAR-mediated modulation of gap junction circuit regulates olfactory learning in C. elegans
title_short	NMDAR-mediated modulation of gap junction circuit regulates olfactory learning in C. elegans
title_full	NMDAR-mediated modulation of gap junction circuit regulates olfactory learning in C. elegans
title_fullStr	NMDAR-mediated modulation of gap junction circuit regulates olfactory learning in C. elegans
title_full_unstemmed	NMDAR-mediated modulation of gap junction circuit regulates olfactory learning in C. elegans
title_sort	nmdar-mediated modulation of gap junction circuit regulates olfactory learning in c. elegans
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/39398b289a3b4e4591f7870378ecd1af
work_keys_str_mv	AT myungkyuchoi nmdarmediatedmodulationofgapjunctioncircuitregulatesolfactorylearningincelegans AT heliu nmdarmediatedmodulationofgapjunctioncircuitregulatesolfactorylearningincelegans AT taihongwu nmdarmediatedmodulationofgapjunctioncircuitregulatesolfactorylearningincelegans AT wenxingyang nmdarmediatedmodulationofgapjunctioncircuitregulatesolfactorylearningincelegans AT yunzhang nmdarmediatedmodulationofgapjunctioncircuitregulatesolfactorylearningincelegans
_version_	1718387317928886272

NMDAR-mediated modulation of gap junction circuit regulates olfactory learning in C. elegans

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