Research progress on the application of nanoparticle drug delivery systems in local drug treatment of periodontitis

Periodontitis is a common oral disease that represents one of the main causes of tooth loss in adults. In recent years, the application of nanotechnology has provided a new drug delivery system and innovative therapy for the treatment of periodontitis and opens up new prospects for the regeneration...

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Autores principales:	ZHANG Xinjian, ZHANG Bin
Formato:	article
Lenguaje:	ZH
Publicado:	Editorial Department of Journal of Prevention and Treatment for Stomatological Diseases 2022
Materias:	periodontitis nanoparticles liposomes polymer nanoparticles inorganic nanoparticles nanocrystals dendrimers delivery system microorganism anti-inflammatory antibacterial drug therapy drug carrier Medicine R
Acceso en línea:	https://doaj.org/article/3939ccd99b474720adf384107cf570d9
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spelling	oai:doaj.org-article:3939ccd99b474720adf384107cf570d92021-11-23T08:25:51ZResearch progress on the application of nanoparticle drug delivery systems in local drug treatment of periodontitis10.12016/j.issn.2096-1456.2022.01.0132096-1456https://doaj.org/article/3939ccd99b474720adf384107cf570d92022-01-01T00:00:00Zhttp://www.kqjbfz.com/CN/10.12016/j.issn.2096-1456.2022.01.013https://doaj.org/toc/2096-1456Periodontitis is a common oral disease that represents one of the main causes of tooth loss in adults. In recent years, the application of nanotechnology has provided a new drug delivery system and innovative therapy for the treatment of periodontitis and opens up new prospects for the regeneration of periodontal tissue. The nanoparticle drug delivery system is composed of degradable carrier materials and drugs. Compared with the traditional film, namely, the fragment and strip-shaped periodontal local drug delivery system, the nanoparticle drug delivery system has the characteristics of biopharmaceuticals and pharmacokinetics. Moreover, it has special advantages, including controlled release of drugs, long-term maintenance of drug concentration, biodegradability and biocompatibility, etc. Antibiotics, protein drugs, such as growth factors, and nucleic acids used for gene delivery or mRNA knockout can be absorbed or dissolved in nanoparticles. Liposomes and polymer nanoparticle delivery systems can target bacteria and specific host cells. Inorganic nanoparticles and nanocrystals have good antibacterial activity that can promote periodontal tissue regeneration and play an important role in bone regeneration and bone repair. Dendrimers have internal hydrophobic and external hydrophilic structures and are good drug carriers for periodontitis.ZHANG XinjianZHANG BinEditorial Department of Journal of Prevention and Treatment for Stomatological Diseasesarticleperiodontitisnanoparticlesliposomespolymer nanoparticlesinorganic nanoparticlesnanocrystalsdendrimersdelivery systemmicroorganismanti-inflammatoryantibacterialdrug therapydrug carrierMedicineRZH口腔疾病防治, Vol 30, Iss 1, Pp 73-76 (2022)
institution	DOAJ
collection	DOAJ
language	ZH
topic	periodontitis nanoparticles liposomes polymer nanoparticles inorganic nanoparticles nanocrystals dendrimers delivery system microorganism anti-inflammatory antibacterial drug therapy drug carrier Medicine R
spellingShingle	periodontitis nanoparticles liposomes polymer nanoparticles inorganic nanoparticles nanocrystals dendrimers delivery system microorganism anti-inflammatory antibacterial drug therapy drug carrier Medicine R ZHANG Xinjian ZHANG Bin Research progress on the application of nanoparticle drug delivery systems in local drug treatment of periodontitis
description	Periodontitis is a common oral disease that represents one of the main causes of tooth loss in adults. In recent years, the application of nanotechnology has provided a new drug delivery system and innovative therapy for the treatment of periodontitis and opens up new prospects for the regeneration of periodontal tissue. The nanoparticle drug delivery system is composed of degradable carrier materials and drugs. Compared with the traditional film, namely, the fragment and strip-shaped periodontal local drug delivery system, the nanoparticle drug delivery system has the characteristics of biopharmaceuticals and pharmacokinetics. Moreover, it has special advantages, including controlled release of drugs, long-term maintenance of drug concentration, biodegradability and biocompatibility, etc. Antibiotics, protein drugs, such as growth factors, and nucleic acids used for gene delivery or mRNA knockout can be absorbed or dissolved in nanoparticles. Liposomes and polymer nanoparticle delivery systems can target bacteria and specific host cells. Inorganic nanoparticles and nanocrystals have good antibacterial activity that can promote periodontal tissue regeneration and play an important role in bone regeneration and bone repair. Dendrimers have internal hydrophobic and external hydrophilic structures and are good drug carriers for periodontitis.
format	article
author	ZHANG Xinjian ZHANG Bin
author_facet	ZHANG Xinjian ZHANG Bin
author_sort	ZHANG Xinjian
title	Research progress on the application of nanoparticle drug delivery systems in local drug treatment of periodontitis
title_short	Research progress on the application of nanoparticle drug delivery systems in local drug treatment of periodontitis
title_full	Research progress on the application of nanoparticle drug delivery systems in local drug treatment of periodontitis
title_fullStr	Research progress on the application of nanoparticle drug delivery systems in local drug treatment of periodontitis
title_full_unstemmed	Research progress on the application of nanoparticle drug delivery systems in local drug treatment of periodontitis
title_sort	research progress on the application of nanoparticle drug delivery systems in local drug treatment of periodontitis
publisher	Editorial Department of Journal of Prevention and Treatment for Stomatological Diseases
publishDate	2022
url	https://doaj.org/article/3939ccd99b474720adf384107cf570d9
work_keys_str_mv	AT zhangxinjian researchprogressontheapplicationofnanoparticledrugdeliverysystemsinlocaldrugtreatmentofperiodontitis AT zhangbin researchprogressontheapplicationofnanoparticledrugdeliverysystemsinlocaldrugtreatmentofperiodontitis
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Research progress on the application of nanoparticle drug delivery systems in local drug treatment of periodontitis

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