Sequencing by hybridization of long targets.

Sequencing by Hybridization (SBH) reconstructs an n-long target DNA sequence from its biochemically determined l-long subsequences. In the standard approach, the length of a uniformly random sequence that can be unambiguously reconstructed is limited to n = O(2(l)) due to repetitive subsequences cau...

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Autores principales:	Yu Qin, Tobias M Schneider, Michael P Brenner
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/393b0e706b0b42b8ac0c11447bc0fc4d
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spelling	oai:doaj.org-article:393b0e706b0b42b8ac0c11447bc0fc4d2021-11-18T07:19:43ZSequencing by hybridization of long targets.1932-620310.1371/journal.pone.0035819https://doaj.org/article/393b0e706b0b42b8ac0c11447bc0fc4d2012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22574124/?tool=EBIhttps://doaj.org/toc/1932-6203Sequencing by Hybridization (SBH) reconstructs an n-long target DNA sequence from its biochemically determined l-long subsequences. In the standard approach, the length of a uniformly random sequence that can be unambiguously reconstructed is limited to n = O(2(l)) due to repetitive subsequences causing reconstruction degeneracies. We present a modified sequencing method that overcomes this limitation without the need for different types of biochemical assays and is robust to error.Yu QinTobias M SchneiderMichael P BrennerPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 5, p e35819 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yu Qin Tobias M Schneider Michael P Brenner Sequencing by hybridization of long targets.
description	Sequencing by Hybridization (SBH) reconstructs an n-long target DNA sequence from its biochemically determined l-long subsequences. In the standard approach, the length of a uniformly random sequence that can be unambiguously reconstructed is limited to n = O(2(l)) due to repetitive subsequences causing reconstruction degeneracies. We present a modified sequencing method that overcomes this limitation without the need for different types of biochemical assays and is robust to error.
format	article
author	Yu Qin Tobias M Schneider Michael P Brenner
author_facet	Yu Qin Tobias M Schneider Michael P Brenner
author_sort	Yu Qin
title	Sequencing by hybridization of long targets.
title_short	Sequencing by hybridization of long targets.
title_full	Sequencing by hybridization of long targets.
title_fullStr	Sequencing by hybridization of long targets.
title_full_unstemmed	Sequencing by hybridization of long targets.
title_sort	sequencing by hybridization of long targets.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/393b0e706b0b42b8ac0c11447bc0fc4d
work_keys_str_mv	AT yuqin sequencingbyhybridizationoflongtargets AT tobiasmschneider sequencingbyhybridizationoflongtargets AT michaelpbrenner sequencingbyhybridizationoflongtargets
_version_	1718423590610665472

Sequencing by hybridization of long targets.

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