Adipogenesis as a Potential Anti-Obesity Target: A Review of Pharmacological Treatment and Natural Products
Jelena Jakab,1,2 Blaženka Miškić,2,3 Štefica Mikšić,2 Brankica Juranić,2,4 Vesna Ćosić,2 Dragan Schwarz,2,5 Aleksandar Včev2 1Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia; 2Faculty of Dental Medicine and Health Osijek, Josip Jura...
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Dove Medical Press
2021
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oai:doaj.org-article:393d8a28922c4962923f7be894a8391c2021-12-02T15:13:18ZAdipogenesis as a Potential Anti-Obesity Target: A Review of Pharmacological Treatment and Natural Products1178-7007https://doaj.org/article/393d8a28922c4962923f7be894a8391c2021-01-01T00:00:00Zhttps://www.dovepress.com/adipogenesis-as-a-potential-anti-obesity-target-a-review-of-pharmacolo-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Jelena Jakab,1,2 Blaženka Miškić,2,3 Štefica Mikšić,2 Brankica Juranić,2,4 Vesna Ćosić,2 Dragan Schwarz,2,5 Aleksandar Včev2 1Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia; 2Faculty of Dental Medicine and Health Osijek, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia; 3Department of Internal Medicine, General Hospital “Dr. Josip Benčević”, Slavonski Brod, Croatia; 4Department of Cardiology, University Hospital Osijek, Osijek, Croatia; 5Special Hospital Radiochirurgia Zagreb, Zagreb, CroatiaCorrespondence: Jelena JakabFaculty of Medicine, Josip Juraj Strossmayer University of Osijek, Crkvena 21, Osijek 31 000, CroatiaTel +385 91 224 1502Email jelena.jakab@fdmz.hrAbstract: Obesity is recognized as a severe threat to overall human health and is associated with type 2 diabetes mellitus, dyslipidemia, hypertension, and cardiovascular diseases. Abnormal expansion of white adipose tissue involves increasing the existing adipocytes’ cell size or increasing the number through the differentiation of new adipocytes. Adipogenesis is a process of proliferation and differentiation of adipocyte precursor cells in mature adipocytes. As a key process in determining the number of adipocytes, it is a possible therapeutic approach for obesity. Therefore, it is necessary to identify the molecular mechanisms involved in adipogenesis that could serve as suitable therapeutic targets. Reducing bodyweight is regarded as a major health benefit. Limited efficacy and possible side effects and drug interactions of available anti-obesity treatment highlight a constant need for finding novel efficient and safe anti-obesity ingredients. Numerous studies have recently investigated the inhibitory effects of natural products on adipocyte differentiation and lipid accumulation. Possible anti-obesity effects of natural products include the induction of apoptosis, cell-cycle arrest or delayed progression, and interference with transcription factor cascade or intracellular signaling pathways during the early phase of adipogenesis.Keywords: adipogenesis, transcriptional cascades, signaling pathways, anti-obesity treatment, bioactive moleculesJakab JMiškić BMikšić SJuranić BĆosić VSchwarz DVčev ADove Medical Pressarticleadipogenesistranscriptional cascadessignaling pathwaysanti-obesity treatmentbioactive moleculesSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 14, Pp 67-83 (2021) |
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adipogenesis transcriptional cascades signaling pathways anti-obesity treatment bioactive molecules Specialties of internal medicine RC581-951 |
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adipogenesis transcriptional cascades signaling pathways anti-obesity treatment bioactive molecules Specialties of internal medicine RC581-951 Jakab J Miškić B Mikšić S Juranić B Ćosić V Schwarz D Včev A Adipogenesis as a Potential Anti-Obesity Target: A Review of Pharmacological Treatment and Natural Products |
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Jelena Jakab,1,2 Blaženka Miškić,2,3 Štefica Mikšić,2 Brankica Juranić,2,4 Vesna Ćosić,2 Dragan Schwarz,2,5 Aleksandar Včev2 1Faculty of Medicine, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia; 2Faculty of Dental Medicine and Health Osijek, Josip Juraj Strossmayer University of Osijek, Osijek, Croatia; 3Department of Internal Medicine, General Hospital “Dr. Josip Benčević”, Slavonski Brod, Croatia; 4Department of Cardiology, University Hospital Osijek, Osijek, Croatia; 5Special Hospital Radiochirurgia Zagreb, Zagreb, CroatiaCorrespondence: Jelena JakabFaculty of Medicine, Josip Juraj Strossmayer University of Osijek, Crkvena 21, Osijek 31 000, CroatiaTel +385 91 224 1502Email jelena.jakab@fdmz.hrAbstract: Obesity is recognized as a severe threat to overall human health and is associated with type 2 diabetes mellitus, dyslipidemia, hypertension, and cardiovascular diseases. Abnormal expansion of white adipose tissue involves increasing the existing adipocytes’ cell size or increasing the number through the differentiation of new adipocytes. Adipogenesis is a process of proliferation and differentiation of adipocyte precursor cells in mature adipocytes. As a key process in determining the number of adipocytes, it is a possible therapeutic approach for obesity. Therefore, it is necessary to identify the molecular mechanisms involved in adipogenesis that could serve as suitable therapeutic targets. Reducing bodyweight is regarded as a major health benefit. Limited efficacy and possible side effects and drug interactions of available anti-obesity treatment highlight a constant need for finding novel efficient and safe anti-obesity ingredients. Numerous studies have recently investigated the inhibitory effects of natural products on adipocyte differentiation and lipid accumulation. Possible anti-obesity effects of natural products include the induction of apoptosis, cell-cycle arrest or delayed progression, and interference with transcription factor cascade or intracellular signaling pathways during the early phase of adipogenesis.Keywords: adipogenesis, transcriptional cascades, signaling pathways, anti-obesity treatment, bioactive molecules |
format |
article |
author |
Jakab J Miškić B Mikšić S Juranić B Ćosić V Schwarz D Včev A |
author_facet |
Jakab J Miškić B Mikšić S Juranić B Ćosić V Schwarz D Včev A |
author_sort |
Jakab J |
title |
Adipogenesis as a Potential Anti-Obesity Target: A Review of Pharmacological Treatment and Natural Products |
title_short |
Adipogenesis as a Potential Anti-Obesity Target: A Review of Pharmacological Treatment and Natural Products |
title_full |
Adipogenesis as a Potential Anti-Obesity Target: A Review of Pharmacological Treatment and Natural Products |
title_fullStr |
Adipogenesis as a Potential Anti-Obesity Target: A Review of Pharmacological Treatment and Natural Products |
title_full_unstemmed |
Adipogenesis as a Potential Anti-Obesity Target: A Review of Pharmacological Treatment and Natural Products |
title_sort |
adipogenesis as a potential anti-obesity target: a review of pharmacological treatment and natural products |
publisher |
Dove Medical Press |
publishDate |
2021 |
url |
https://doaj.org/article/393d8a28922c4962923f7be894a8391c |
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