Molecular Imaging in Primary Staging of Prostate Cancer Patients: Current Aspects and Future Trends

Accurate primary staging is the cornerstone in all malignancies. Different morphological imaging modalities are employed in the evaluation of prostate cancer (PCa). Regardless of all developments in imaging, invasive histopathologic evaluation is still the standard method for the detection and stagi...

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Autores principales:	Reyhaneh Manafi-Farid, Shaghayegh Ranjbar, Zahra Jamshidi Araghi, Julia Pilz, Gregor Schweighofer-Zwink, Christian Pirich, Mohsen Beheshti
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	prostate cancer primary staging PET/CT [<sup>11</sup>C]choline [<sup>18</sup>F]choline [<sup>11</sup>C]acetate Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/393dcb7411f740d384831462d8c50367
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spelling	oai:doaj.org-article:393dcb7411f740d384831462d8c503672021-11-11T15:29:00ZMolecular Imaging in Primary Staging of Prostate Cancer Patients: Current Aspects and Future Trends10.3390/cancers132153602072-6694https://doaj.org/article/393dcb7411f740d384831462d8c503672021-10-01T00:00:00Zhttps://www.mdpi.com/2072-6694/13/21/5360https://doaj.org/toc/2072-6694Accurate primary staging is the cornerstone in all malignancies. Different morphological imaging modalities are employed in the evaluation of prostate cancer (PCa). Regardless of all developments in imaging, invasive histopathologic evaluation is still the standard method for the detection and staging of the primary PCa. Magnetic resonance imaging (MRI) and computed tomography (CT) play crucial roles; however, functional imaging provides additional valuable information, and it is gaining ever-growing acceptance in the management of PCa. Targeted imaging with different radiotracers has remarkably evolved in the past two decades. [<sup>111</sup>In]In-capromab pendetide scintigraphy was a new approach in the management of PCa. Afterwards, positron emission tomography (PET) tracers such as [<sup>11</sup>C/<sup>18</sup>F]choline and [<sup>11</sup>C]acetate were developed. Nevertheless, none found a role in the primary staging. By introduction of the highly sensitive small molecule prostate-specific membrane antigen (PSMA) PET/CT, as well as recent developments in MRI and hybrid PET/MRI systems, non-invasive staging of PCa is being contemplated. Several studies investigated the role of these sophisticated modalities in the primary staging of PCa, showing promising results. Here, we recapitulate the role of targeted functional imaging. We briefly mention the most popular radiotracers, their diagnostic accuracy in the primary staging of PCa, and impact on patient management.Reyhaneh Manafi-FaridShaghayegh RanjbarZahra Jamshidi AraghiJulia PilzGregor Schweighofer-ZwinkChristian PirichMohsen BeheshtiMDPI AGarticleprostate cancerprimary stagingPET/CT[<sup>11</sup>C]choline[<sup>18</sup>F]choline[<sup>11</sup>C]acetateNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENCancers, Vol 13, Iss 5360, p 5360 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	prostate cancer primary staging PET/CT [<sup>11</sup>C]choline [<sup>18</sup>F]choline [<sup>11</sup>C]acetate Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	prostate cancer primary staging PET/CT [<sup>11</sup>C]choline [<sup>18</sup>F]choline [<sup>11</sup>C]acetate Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Reyhaneh Manafi-Farid Shaghayegh Ranjbar Zahra Jamshidi Araghi Julia Pilz Gregor Schweighofer-Zwink Christian Pirich Mohsen Beheshti Molecular Imaging in Primary Staging of Prostate Cancer Patients: Current Aspects and Future Trends
description	Accurate primary staging is the cornerstone in all malignancies. Different morphological imaging modalities are employed in the evaluation of prostate cancer (PCa). Regardless of all developments in imaging, invasive histopathologic evaluation is still the standard method for the detection and staging of the primary PCa. Magnetic resonance imaging (MRI) and computed tomography (CT) play crucial roles; however, functional imaging provides additional valuable information, and it is gaining ever-growing acceptance in the management of PCa. Targeted imaging with different radiotracers has remarkably evolved in the past two decades. [<sup>111</sup>In]In-capromab pendetide scintigraphy was a new approach in the management of PCa. Afterwards, positron emission tomography (PET) tracers such as [<sup>11</sup>C/<sup>18</sup>F]choline and [<sup>11</sup>C]acetate were developed. Nevertheless, none found a role in the primary staging. By introduction of the highly sensitive small molecule prostate-specific membrane antigen (PSMA) PET/CT, as well as recent developments in MRI and hybrid PET/MRI systems, non-invasive staging of PCa is being contemplated. Several studies investigated the role of these sophisticated modalities in the primary staging of PCa, showing promising results. Here, we recapitulate the role of targeted functional imaging. We briefly mention the most popular radiotracers, their diagnostic accuracy in the primary staging of PCa, and impact on patient management.
format	article
author	Reyhaneh Manafi-Farid Shaghayegh Ranjbar Zahra Jamshidi Araghi Julia Pilz Gregor Schweighofer-Zwink Christian Pirich Mohsen Beheshti
author_facet	Reyhaneh Manafi-Farid Shaghayegh Ranjbar Zahra Jamshidi Araghi Julia Pilz Gregor Schweighofer-Zwink Christian Pirich Mohsen Beheshti
author_sort	Reyhaneh Manafi-Farid
title	Molecular Imaging in Primary Staging of Prostate Cancer Patients: Current Aspects and Future Trends
title_short	Molecular Imaging in Primary Staging of Prostate Cancer Patients: Current Aspects and Future Trends
title_full	Molecular Imaging in Primary Staging of Prostate Cancer Patients: Current Aspects and Future Trends
title_fullStr	Molecular Imaging in Primary Staging of Prostate Cancer Patients: Current Aspects and Future Trends
title_full_unstemmed	Molecular Imaging in Primary Staging of Prostate Cancer Patients: Current Aspects and Future Trends
title_sort	molecular imaging in primary staging of prostate cancer patients: current aspects and future trends
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/393dcb7411f740d384831462d8c50367
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Molecular Imaging in Primary Staging of Prostate Cancer Patients: Current Aspects and Future Trends

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