In situ dissection of domain boundaries affect genome topology and gene transcription in Drosophila

In Drosophila, transcription is thought to be required for TAD formation, while the role of architectural proteins remains controversial. Here, the authors find that deletion of domain boundaries at the fly Notch locus results in TAD fusion and long-range topological defects, loss of architectural p...

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Autores principales:	Rodrigo G. Arzate-Mejía, Angel Josué Cerecedo-Castillo, Georgina Guerrero, Mayra Furlan-Magaril, Félix Recillas-Targa
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/393e8b7027a242d192e00adcd68c2093
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spelling	oai:doaj.org-article:393e8b7027a242d192e00adcd68c20932021-12-02T16:49:15ZIn situ dissection of domain boundaries affect genome topology and gene transcription in Drosophila10.1038/s41467-020-14651-z2041-1723https://doaj.org/article/393e8b7027a242d192e00adcd68c20932020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14651-zhttps://doaj.org/toc/2041-1723In Drosophila, transcription is thought to be required for TAD formation, while the role of architectural proteins remains controversial. Here, the authors find that deletion of domain boundaries at the fly Notch locus results in TAD fusion and long-range topological defects, loss of architectural protein and RNA Pol II chromatin binding, and transcription defects.Rodrigo G. Arzate-MejíaAngel Josué Cerecedo-CastilloGeorgina GuerreroMayra Furlan-MagarilFélix Recillas-TargaNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Rodrigo G. Arzate-Mejía Angel Josué Cerecedo-Castillo Georgina Guerrero Mayra Furlan-Magaril Félix Recillas-Targa In situ dissection of domain boundaries affect genome topology and gene transcription in Drosophila
description	In Drosophila, transcription is thought to be required for TAD formation, while the role of architectural proteins remains controversial. Here, the authors find that deletion of domain boundaries at the fly Notch locus results in TAD fusion and long-range topological defects, loss of architectural protein and RNA Pol II chromatin binding, and transcription defects.
format	article
author	Rodrigo G. Arzate-Mejía Angel Josué Cerecedo-Castillo Georgina Guerrero Mayra Furlan-Magaril Félix Recillas-Targa
author_facet	Rodrigo G. Arzate-Mejía Angel Josué Cerecedo-Castillo Georgina Guerrero Mayra Furlan-Magaril Félix Recillas-Targa
author_sort	Rodrigo G. Arzate-Mejía
title	In situ dissection of domain boundaries affect genome topology and gene transcription in Drosophila
title_short	In situ dissection of domain boundaries affect genome topology and gene transcription in Drosophila
title_full	In situ dissection of domain boundaries affect genome topology and gene transcription in Drosophila
title_fullStr	In situ dissection of domain boundaries affect genome topology and gene transcription in Drosophila
title_full_unstemmed	In situ dissection of domain boundaries affect genome topology and gene transcription in Drosophila
title_sort	in situ dissection of domain boundaries affect genome topology and gene transcription in drosophila
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/393e8b7027a242d192e00adcd68c2093
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In situ dissection of domain boundaries affect genome topology and gene transcription in Drosophila

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