Biochemistry, hormones and adipocytokines in prepubertal children born with IUGR evoke metabolic, hepatic and renal derangements

Abstract Children born with IUGR develop features of the metabolic syndrome and exhibit deranged markers of hepatorenal physiology. Metabolic and hepatorenal biochemistry and the rs9939609 FTO polymorphism were investigated in prepubertal children born with IUGR. Ninety-eight prepubertal children (4...

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Autores principales:	Elpida J. Sidiropoulou, George Paltoglou, George Valsamakis, Alexandra Margeli, Aimilia Mantzou, Ioannis Papassotiriou, Dimitrios Hassiakos, Nicoletta Iacovidou, George Mastorakos
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Intrauterine Growth Restriction (IUGR) Renal Derangement Adiponectin Concentrations Quantitative Insulin Sensitivity Check Index (QUICKI) Glucose Metabolism Parameters Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3941efc968e145f3b4020a552f3a481e
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spelling	oai:doaj.org-article:3941efc968e145f3b4020a552f3a481e2021-12-02T15:09:12ZBiochemistry, hormones and adipocytokines in prepubertal children born with IUGR evoke metabolic, hepatic and renal derangements10.1038/s41598-018-34075-62045-2322https://doaj.org/article/3941efc968e145f3b4020a552f3a481e2018-10-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-34075-6https://doaj.org/toc/2045-2322Abstract Children born with IUGR develop features of the metabolic syndrome and exhibit deranged markers of hepatorenal physiology. Metabolic and hepatorenal biochemistry and the rs9939609 FTO polymorphism were investigated in prepubertal children born with IUGR. Ninety-eight prepubertal children (46 IUGR and 52 AGA), subdivided in <5 years and >5 years old groups were included. Anthropometry; creatinine, eGFR, urea, AST, ALT, triglycerides, uric acid, total cholesterol, HDL-c, LDL-c, glucose, C-peptide, insulin and glucagon z-scores; HOMA-IR; leptin and adiponectin concentrations; rs9939609 FTO polymorphism frequency were measured. In males, weight and ALT were higher and adiponectin was lower, in IUGR < 5 years; C-peptide, insulin and leptin were higher in IUGR > 5 years; C-peptide was higher in all IUGR, than the respective AGA. In females, creatinine and triglycerides were higher in IUGR < 5 years old; creatinine was higher and eGFR was lower in all IUGR, than the respective AGA. In males and females, creatinine was higher in all IUGR, than the respective AGA; C-peptide, insulin and HOMA-IR were lower, and AST was higher in IUGR < 5 than in IUGR > 5 years old. FTO rs9939609 frequency did not differ between IUGR and AGA. In conclusion prepubertal males born with IUGR increased weight, insulin and leptin and decreased adiponectin, as compared to males born AGA, emerge as early metabolic syndrome characteristics. The concentrations of these hormones do not differ between prepubertal males and females born with IUGR. Weight control, healthy nutrition and physical exercise should be recommended to these children. The deranged renal (particularly evident in females below the age of 5) and liver biochemistry in prepubertal children born with IUGR suggests that hepatorenal derangements might commence in utero. Regular checkup of biochemical and lipid profile is recommended for all children born with IUGR.Elpida J. SidiropoulouGeorge PaltoglouGeorge ValsamakisAlexandra MargeliAimilia MantzouIoannis PapassotiriouDimitrios HassiakosNicoletta IacovidouGeorge MastorakosNature PortfolioarticleIntrauterine Growth Restriction (IUGR)Renal DerangementAdiponectin ConcentrationsQuantitative Insulin Sensitivity Check Index (QUICKI)Glucose Metabolism ParametersMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Intrauterine Growth Restriction (IUGR) Renal Derangement Adiponectin Concentrations Quantitative Insulin Sensitivity Check Index (QUICKI) Glucose Metabolism Parameters Medicine R Science Q
spellingShingle	Intrauterine Growth Restriction (IUGR) Renal Derangement Adiponectin Concentrations Quantitative Insulin Sensitivity Check Index (QUICKI) Glucose Metabolism Parameters Medicine R Science Q Elpida J. Sidiropoulou George Paltoglou George Valsamakis Alexandra Margeli Aimilia Mantzou Ioannis Papassotiriou Dimitrios Hassiakos Nicoletta Iacovidou George Mastorakos Biochemistry, hormones and adipocytokines in prepubertal children born with IUGR evoke metabolic, hepatic and renal derangements
description	Abstract Children born with IUGR develop features of the metabolic syndrome and exhibit deranged markers of hepatorenal physiology. Metabolic and hepatorenal biochemistry and the rs9939609 FTO polymorphism were investigated in prepubertal children born with IUGR. Ninety-eight prepubertal children (46 IUGR and 52 AGA), subdivided in <5 years and >5 years old groups were included. Anthropometry; creatinine, eGFR, urea, AST, ALT, triglycerides, uric acid, total cholesterol, HDL-c, LDL-c, glucose, C-peptide, insulin and glucagon z-scores; HOMA-IR; leptin and adiponectin concentrations; rs9939609 FTO polymorphism frequency were measured. In males, weight and ALT were higher and adiponectin was lower, in IUGR < 5 years; C-peptide, insulin and leptin were higher in IUGR > 5 years; C-peptide was higher in all IUGR, than the respective AGA. In females, creatinine and triglycerides were higher in IUGR < 5 years old; creatinine was higher and eGFR was lower in all IUGR, than the respective AGA. In males and females, creatinine was higher in all IUGR, than the respective AGA; C-peptide, insulin and HOMA-IR were lower, and AST was higher in IUGR < 5 than in IUGR > 5 years old. FTO rs9939609 frequency did not differ between IUGR and AGA. In conclusion prepubertal males born with IUGR increased weight, insulin and leptin and decreased adiponectin, as compared to males born AGA, emerge as early metabolic syndrome characteristics. The concentrations of these hormones do not differ between prepubertal males and females born with IUGR. Weight control, healthy nutrition and physical exercise should be recommended to these children. The deranged renal (particularly evident in females below the age of 5) and liver biochemistry in prepubertal children born with IUGR suggests that hepatorenal derangements might commence in utero. Regular checkup of biochemical and lipid profile is recommended for all children born with IUGR.
format	article
author	Elpida J. Sidiropoulou George Paltoglou George Valsamakis Alexandra Margeli Aimilia Mantzou Ioannis Papassotiriou Dimitrios Hassiakos Nicoletta Iacovidou George Mastorakos
author_facet	Elpida J. Sidiropoulou George Paltoglou George Valsamakis Alexandra Margeli Aimilia Mantzou Ioannis Papassotiriou Dimitrios Hassiakos Nicoletta Iacovidou George Mastorakos
author_sort	Elpida J. Sidiropoulou
title	Biochemistry, hormones and adipocytokines in prepubertal children born with IUGR evoke metabolic, hepatic and renal derangements
title_short	Biochemistry, hormones and adipocytokines in prepubertal children born with IUGR evoke metabolic, hepatic and renal derangements
title_full	Biochemistry, hormones and adipocytokines in prepubertal children born with IUGR evoke metabolic, hepatic and renal derangements
title_fullStr	Biochemistry, hormones and adipocytokines in prepubertal children born with IUGR evoke metabolic, hepatic and renal derangements
title_full_unstemmed	Biochemistry, hormones and adipocytokines in prepubertal children born with IUGR evoke metabolic, hepatic and renal derangements
title_sort	biochemistry, hormones and adipocytokines in prepubertal children born with iugr evoke metabolic, hepatic and renal derangements
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/3941efc968e145f3b4020a552f3a481e
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Biochemistry, hormones and adipocytokines in prepubertal children born with IUGR evoke metabolic, hepatic and renal derangements

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