A systems pharmacology approach to identify the autophagy-inducing effects of Traditional Persian medicinal plants

Abstract Aging is correlated with several complex diseases, including type 2 diabetes, neurodegeneration diseases, and cancer. Identifying the nature of this correlation and treatment of age-related diseases has been a major subject of both modern and traditional medicine. Traditional Persian Medici...

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Autores principales:	Pouria Mosaddeghi, Mahboobeh Eslami, Mitra Farahmandnejad, Mahshad Akhavein, Ratin Ranjbarfarrokhi, Mohammadhossein Khorraminejad-Shirazi, Farbod Shahabinezhad, Mohammadjavad Taghipour, Mohammadreza Dorvash, Amirhossein Sakhteman, Mohammad M. Zarshenas, Navid Nezafat, Meysam Mobasheri, Younes Ghasemi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/394332cd0e3b474ab5146d79d632744b
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spelling	oai:doaj.org-article:394332cd0e3b474ab5146d79d632744b2021-12-02T15:23:03ZA systems pharmacology approach to identify the autophagy-inducing effects of Traditional Persian medicinal plants10.1038/s41598-020-79472-y2045-2322https://doaj.org/article/394332cd0e3b474ab5146d79d632744b2021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-79472-yhttps://doaj.org/toc/2045-2322Abstract Aging is correlated with several complex diseases, including type 2 diabetes, neurodegeneration diseases, and cancer. Identifying the nature of this correlation and treatment of age-related diseases has been a major subject of both modern and traditional medicine. Traditional Persian Medicine (TPM) embodies many prescriptions for the treatment of ARDs. Given that autophagy plays a critical role in antiaging processes, the present study aimed to examine whether the documented effect of plants used in TPM might be relevant to the induction of autophagy? To this end, the TPM-based medicinal herbs used in the treatment of the ARDs were identified from modern and traditional references. The known phytochemicals of these plants were then examined against literature for evidence of having autophagy inducing effects. As a result, several plants were identified to have multiple active ingredients, which indeed regulate the autophagy or its upstream pathways. In addition, gene set enrichment analysis of the identified targets confirmed the collective contribution of the identified targets in autophagy regulating processes. Also, the protein–protein interaction (PPI) network of the targets was reconstructed. Network centrality analysis of the PPI network identified mTOR as the key network hub. Given the well-documented role of mTOR in inhibiting autophagy, our results hence support the hypothesis that the antiaging mechanism of TPM-based medicines might involve autophagy induction. Chemoinformatics study of the phytochemicals using docking and molecular dynamics simulation identified, among other compounds, the cyclo-trijuglone of Juglans regia L. as a potential ATP-competitive inhibitor of mTOR. Our results hence, provide a basis for the study of TPM-based prescriptions using modern tools in the quest for developing synergistic therapies for ARDs.Pouria MosaddeghiMahboobeh EslamiMitra FarahmandnejadMahshad AkhaveinRatin RanjbarfarrokhiMohammadhossein Khorraminejad-ShiraziFarbod ShahabinezhadMohammadjavad TaghipourMohammadreza DorvashAmirhossein SakhtemanMohammad M. ZarshenasNavid NezafatMeysam MobasheriYounes GhasemiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Pouria Mosaddeghi Mahboobeh Eslami Mitra Farahmandnejad Mahshad Akhavein Ratin Ranjbarfarrokhi Mohammadhossein Khorraminejad-Shirazi Farbod Shahabinezhad Mohammadjavad Taghipour Mohammadreza Dorvash Amirhossein Sakhteman Mohammad M. Zarshenas Navid Nezafat Meysam Mobasheri Younes Ghasemi A systems pharmacology approach to identify the autophagy-inducing effects of Traditional Persian medicinal plants
description	Abstract Aging is correlated with several complex diseases, including type 2 diabetes, neurodegeneration diseases, and cancer. Identifying the nature of this correlation and treatment of age-related diseases has been a major subject of both modern and traditional medicine. Traditional Persian Medicine (TPM) embodies many prescriptions for the treatment of ARDs. Given that autophagy plays a critical role in antiaging processes, the present study aimed to examine whether the documented effect of plants used in TPM might be relevant to the induction of autophagy? To this end, the TPM-based medicinal herbs used in the treatment of the ARDs were identified from modern and traditional references. The known phytochemicals of these plants were then examined against literature for evidence of having autophagy inducing effects. As a result, several plants were identified to have multiple active ingredients, which indeed regulate the autophagy or its upstream pathways. In addition, gene set enrichment analysis of the identified targets confirmed the collective contribution of the identified targets in autophagy regulating processes. Also, the protein–protein interaction (PPI) network of the targets was reconstructed. Network centrality analysis of the PPI network identified mTOR as the key network hub. Given the well-documented role of mTOR in inhibiting autophagy, our results hence support the hypothesis that the antiaging mechanism of TPM-based medicines might involve autophagy induction. Chemoinformatics study of the phytochemicals using docking and molecular dynamics simulation identified, among other compounds, the cyclo-trijuglone of Juglans regia L. as a potential ATP-competitive inhibitor of mTOR. Our results hence, provide a basis for the study of TPM-based prescriptions using modern tools in the quest for developing synergistic therapies for ARDs.
format	article
author	Pouria Mosaddeghi Mahboobeh Eslami Mitra Farahmandnejad Mahshad Akhavein Ratin Ranjbarfarrokhi Mohammadhossein Khorraminejad-Shirazi Farbod Shahabinezhad Mohammadjavad Taghipour Mohammadreza Dorvash Amirhossein Sakhteman Mohammad M. Zarshenas Navid Nezafat Meysam Mobasheri Younes Ghasemi
author_facet	Pouria Mosaddeghi Mahboobeh Eslami Mitra Farahmandnejad Mahshad Akhavein Ratin Ranjbarfarrokhi Mohammadhossein Khorraminejad-Shirazi Farbod Shahabinezhad Mohammadjavad Taghipour Mohammadreza Dorvash Amirhossein Sakhteman Mohammad M. Zarshenas Navid Nezafat Meysam Mobasheri Younes Ghasemi
author_sort	Pouria Mosaddeghi
title	A systems pharmacology approach to identify the autophagy-inducing effects of Traditional Persian medicinal plants
title_short	A systems pharmacology approach to identify the autophagy-inducing effects of Traditional Persian medicinal plants
title_full	A systems pharmacology approach to identify the autophagy-inducing effects of Traditional Persian medicinal plants
title_fullStr	A systems pharmacology approach to identify the autophagy-inducing effects of Traditional Persian medicinal plants
title_full_unstemmed	A systems pharmacology approach to identify the autophagy-inducing effects of Traditional Persian medicinal plants
title_sort	systems pharmacology approach to identify the autophagy-inducing effects of traditional persian medicinal plants
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/394332cd0e3b474ab5146d79d632744b
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A systems pharmacology approach to identify the autophagy-inducing effects of Traditional Persian medicinal plants

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