The F-BAR protein pacsin2 inhibits asymmetric VE-cadherin internalization from tensile adherens junctions

Cell-cell adhesion of endothelial tissue, mediated by the adhesion molecule VE-cadherin, is tightly regulated. Here the authors show that the F-BAR domain protein pacsin2 is recruited to the trailing end of mechanically unbalanced Focal Adherens Junctions, where it inhibits internalization of VE-cad...

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Autores principales:	Yvonne L. Dorland, Tsveta S. Malinova, Anne-Marieke D. van Stalborch, Adam G. Grieve, Daphne van Geemen, Nicolette S. Jansen, Bart-Jan de Kreuk, Kalim Nawaz, Jeroen Kole, Dirk Geerts, René J. P. Musters, Johan de Rooij, Peter L. Hordijk, Stephan Huveneers
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/39489597f19d45109896f9a7f11b9fb8
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spelling	oai:doaj.org-article:39489597f19d45109896f9a7f11b9fb82021-12-02T15:35:25ZThe F-BAR protein pacsin2 inhibits asymmetric VE-cadherin internalization from tensile adherens junctions10.1038/ncomms122102041-1723https://doaj.org/article/39489597f19d45109896f9a7f11b9fb82016-07-01T00:00:00Zhttps://doi.org/10.1038/ncomms12210https://doaj.org/toc/2041-1723Cell-cell adhesion of endothelial tissue, mediated by the adhesion molecule VE-cadherin, is tightly regulated. Here the authors show that the F-BAR domain protein pacsin2 is recruited to the trailing end of mechanically unbalanced Focal Adherens Junctions, where it inhibits internalization of VE-cadherin and protects cell-cell adhesion.Yvonne L. DorlandTsveta S. MalinovaAnne-Marieke D. van StalborchAdam G. GrieveDaphne van GeemenNicolette S. JansenBart-Jan de KreukKalim NawazJeroen KoleDirk GeertsRené J. P. MustersJohan de RooijPeter L. HordijkStephan HuveneersNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-18 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yvonne L. Dorland Tsveta S. Malinova Anne-Marieke D. van Stalborch Adam G. Grieve Daphne van Geemen Nicolette S. Jansen Bart-Jan de Kreuk Kalim Nawaz Jeroen Kole Dirk Geerts René J. P. Musters Johan de Rooij Peter L. Hordijk Stephan Huveneers The F-BAR protein pacsin2 inhibits asymmetric VE-cadherin internalization from tensile adherens junctions
description	Cell-cell adhesion of endothelial tissue, mediated by the adhesion molecule VE-cadherin, is tightly regulated. Here the authors show that the F-BAR domain protein pacsin2 is recruited to the trailing end of mechanically unbalanced Focal Adherens Junctions, where it inhibits internalization of VE-cadherin and protects cell-cell adhesion.
format	article
author	Yvonne L. Dorland Tsveta S. Malinova Anne-Marieke D. van Stalborch Adam G. Grieve Daphne van Geemen Nicolette S. Jansen Bart-Jan de Kreuk Kalim Nawaz Jeroen Kole Dirk Geerts René J. P. Musters Johan de Rooij Peter L. Hordijk Stephan Huveneers
author_facet	Yvonne L. Dorland Tsveta S. Malinova Anne-Marieke D. van Stalborch Adam G. Grieve Daphne van Geemen Nicolette S. Jansen Bart-Jan de Kreuk Kalim Nawaz Jeroen Kole Dirk Geerts René J. P. Musters Johan de Rooij Peter L. Hordijk Stephan Huveneers
author_sort	Yvonne L. Dorland
title	The F-BAR protein pacsin2 inhibits asymmetric VE-cadherin internalization from tensile adherens junctions
title_short	The F-BAR protein pacsin2 inhibits asymmetric VE-cadherin internalization from tensile adherens junctions
title_full	The F-BAR protein pacsin2 inhibits asymmetric VE-cadherin internalization from tensile adherens junctions
title_fullStr	The F-BAR protein pacsin2 inhibits asymmetric VE-cadherin internalization from tensile adherens junctions
title_full_unstemmed	The F-BAR protein pacsin2 inhibits asymmetric VE-cadherin internalization from tensile adherens junctions
title_sort	f-bar protein pacsin2 inhibits asymmetric ve-cadherin internalization from tensile adherens junctions
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/39489597f19d45109896f9a7f11b9fb8
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The F-BAR protein pacsin2 inhibits asymmetric VE-cadherin internalization from tensile adherens junctions

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