The role of dissociation in ketamine’s antidepressant effects

Ketamine is associated with rapid antidepressant effects and temporary dissociative experiences, and this review examines whether these dissociative symptoms are necessary for antidepressant efficacy. Although the current literature does not support this relationship, further work is needed to explo...

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Autores principales:	Elizabeth D. Ballard, Carlos A. Zarate
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/394919950fd04c0ab1c26373e36a6bc7
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spelling	oai:doaj.org-article:394919950fd04c0ab1c26373e36a6bc72021-12-02T14:16:32ZThe role of dissociation in ketamine’s antidepressant effects10.1038/s41467-020-20190-42041-1723https://doaj.org/article/394919950fd04c0ab1c26373e36a6bc72020-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20190-4https://doaj.org/toc/2041-1723Ketamine is associated with rapid antidepressant effects and temporary dissociative experiences, and this review examines whether these dissociative symptoms are necessary for antidepressant efficacy. Although the current literature does not support this relationship, further work is needed to explore possible associations at the molecular, biomarker, and psychological levels.Elizabeth D. BallardCarlos A. ZarateNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-7 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Elizabeth D. Ballard Carlos A. Zarate The role of dissociation in ketamine’s antidepressant effects
description	Ketamine is associated with rapid antidepressant effects and temporary dissociative experiences, and this review examines whether these dissociative symptoms are necessary for antidepressant efficacy. Although the current literature does not support this relationship, further work is needed to explore possible associations at the molecular, biomarker, and psychological levels.
format	article
author	Elizabeth D. Ballard Carlos A. Zarate
author_facet	Elizabeth D. Ballard Carlos A. Zarate
author_sort	Elizabeth D. Ballard
title	The role of dissociation in ketamine’s antidepressant effects
title_short	The role of dissociation in ketamine’s antidepressant effects
title_full	The role of dissociation in ketamine’s antidepressant effects
title_fullStr	The role of dissociation in ketamine’s antidepressant effects
title_full_unstemmed	The role of dissociation in ketamine’s antidepressant effects
title_sort	role of dissociation in ketamine’s antidepressant effects
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/394919950fd04c0ab1c26373e36a6bc7
work_keys_str_mv	AT elizabethdballard theroleofdissociationinketaminesantidepressanteffects AT carlosazarate theroleofdissociationinketaminesantidepressanteffects AT elizabethdballard roleofdissociationinketaminesantidepressanteffects AT carlosazarate roleofdissociationinketaminesantidepressanteffects
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The role of dissociation in ketamine’s antidepressant effects

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