Impact of aging on cardiac function in a female rat model of menopause: role of autonomic control, inflammation, and oxidative stress

Jacqueline Freire Machi,1,2 Danielle da Silva Dias,3 Sarah Cristina Freitas,3 Oscar Albuquerque de Moraes,1 Maikon Barbosa da Silva,1 Paula Lázara Cruz,1 Cristiano Mostarda,4 Vera M C Salemi,1 Mariana Morris,2 Kátia De Angelis,3 Maria-Cláudia Irigoyen1 1Hypertension...

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Autores principales:	Machi JF, Dias DS, Freitas SC, Moraes OA, da Silva MB, Cruz PL, Mostarda C, Salemi VMC, Morris M, De Angelis K, Irigoyen MC
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	aging menopause autonomic nervous system echocardiography inflammation oxidative stress rats. Geriatrics RC952-954.6
Acceso en línea:	https://doaj.org/article/394ea01a003c4b728e47e67a7ad13063
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spelling	oai:doaj.org-article:394ea01a003c4b728e47e67a7ad130632021-12-02T05:35:39ZImpact of aging on cardiac function in a female rat model of menopause: role of autonomic control, inflammation, and oxidative stress1178-1998https://doaj.org/article/394ea01a003c4b728e47e67a7ad130632016-03-01T00:00:00Zhttps://www.dovepress.com/impact-of-aging-on-cardiac-function-in-a-female-rat-model-of-menopause-peer-reviewed-article-CIAhttps://doaj.org/toc/1178-1998Jacqueline Freire Machi,1,2 Danielle da Silva Dias,3 Sarah Cristina Freitas,3 Oscar Albuquerque de Moraes,1 Maikon Barbosa da Silva,1 Paula Lázara Cruz,1 Cristiano Mostarda,4 Vera M C Salemi,1 Mariana Morris,2 Kátia De Angelis,3 Maria-Cláudia Irigoyen1 1Hypertension Unit, Heart Institute (InCor), School of Medicine, University of Sao Paulo, São Paulo, Brazil; 2Institute of Neuro-Immune Medicine, Nova Southeastern University, Fort Lauderdale, FL, USA; 3Laboratory of Translational Physiology, Universidade Nove de Julho (UNINOVE), São Paulo, 4Health Adult and Child, Federal University of Maranhao (UFMA), São Luiz, Maranhão, Brazil Objective: The aim of this study was to evaluate the effects of aging on metabolic, cardiovascular, autonomic, inflammatory, and oxidative stress parameters after ovarian hormone deprivation (OVX). Methods: Female Wistar rats (3 or 22 months old) were divided into: young controls, young ovariectomized, old controls, and old ovariectomized (bilateral ovaries removal). After a 9-week follow-up, physical capacity, metabolic parameters, and morphometric and cardiac functions were assessed. Subsequently, arterial pressure was recorded and cardiac autonomic control was evaluated. Oxidative stress was measured on the cardiac tissue, while inflammatory profile was assessed in the plasma. Results: Aging or OVX caused an increase in body and fat weight and triglyceride concentration and a decrease in both insulin sensitivity and aerobic exercise capacity. Left ventricular diastolic dysfunction and increased cardiac overload (myocardial performance index) were reported in old groups when compared with young groups. Aging and OVX led to an increased sympathetic tonus, and vagal tonus was lower only for the old groups. Tumor necrosis factor-α and interleukin-6 were increased in old groups when compared with young groups. Glutathione redox balance (GSH/GSSG) was reduced in young ovariectomized, old controls, and old ovariectomized groups when compared with young controls, indicating an increased oxidative stress. A negative correlation was found between GSH/GSSG and tumor necrosis factor-α (r=-0.6, P<0.003). Correlations were found between interleukin-6 with adipose tissue (r=0.5, P<0.009) and vagal tonus (r=-0.7, P<0.0002); and among myocardial performance index with interleukin-6 (r=0.65, P<0.0002), sympathetic tonus (r=0.55, P<0.006), and physical capacity (r=-0.55, P<0.003). The findings in this trial showed that ovariectomy aggravated the impairment of cardiac and functional effects of aging in female rats, probably associated with exacerbated autonomic dysfunction, inflammation, and oxidative stress. Keywords: autonomic nervous system, aging, aerobic exercise, female ratsMachi JFDias DSFreitas SCMoraes OAda Silva MBCruz PLMostarda CSalemi VMCMorris MDe Angelis KIrigoyen MCDove Medical Pressarticleagingmenopauseautonomic nervous systemechocardiographyinflammationoxidative stressrats.GeriatricsRC952-954.6ENClinical Interventions in Aging, Vol Volume 11, Pp 341-350 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	aging menopause autonomic nervous system echocardiography inflammation oxidative stress rats. Geriatrics RC952-954.6
spellingShingle	aging menopause autonomic nervous system echocardiography inflammation oxidative stress rats. Geriatrics RC952-954.6 Machi JF Dias DS Freitas SC Moraes OA da Silva MB Cruz PL Mostarda C Salemi VMC Morris M De Angelis K Irigoyen MC Impact of aging on cardiac function in a female rat model of menopause: role of autonomic control, inflammation, and oxidative stress
description	Jacqueline Freire Machi,1,2 Danielle da Silva Dias,3 Sarah Cristina Freitas,3 Oscar Albuquerque de Moraes,1 Maikon Barbosa da Silva,1 Paula Lázara Cruz,1 Cristiano Mostarda,4 Vera M C Salemi,1 Mariana Morris,2 Kátia De Angelis,3 Maria-Cláudia Irigoyen1 1Hypertension Unit, Heart Institute (InCor), School of Medicine, University of Sao Paulo, São Paulo, Brazil; 2Institute of Neuro-Immune Medicine, Nova Southeastern University, Fort Lauderdale, FL, USA; 3Laboratory of Translational Physiology, Universidade Nove de Julho (UNINOVE), São Paulo, 4Health Adult and Child, Federal University of Maranhao (UFMA), São Luiz, Maranhão, Brazil Objective: The aim of this study was to evaluate the effects of aging on metabolic, cardiovascular, autonomic, inflammatory, and oxidative stress parameters after ovarian hormone deprivation (OVX). Methods: Female Wistar rats (3 or 22 months old) were divided into: young controls, young ovariectomized, old controls, and old ovariectomized (bilateral ovaries removal). After a 9-week follow-up, physical capacity, metabolic parameters, and morphometric and cardiac functions were assessed. Subsequently, arterial pressure was recorded and cardiac autonomic control was evaluated. Oxidative stress was measured on the cardiac tissue, while inflammatory profile was assessed in the plasma. Results: Aging or OVX caused an increase in body and fat weight and triglyceride concentration and a decrease in both insulin sensitivity and aerobic exercise capacity. Left ventricular diastolic dysfunction and increased cardiac overload (myocardial performance index) were reported in old groups when compared with young groups. Aging and OVX led to an increased sympathetic tonus, and vagal tonus was lower only for the old groups. Tumor necrosis factor-α and interleukin-6 were increased in old groups when compared with young groups. Glutathione redox balance (GSH/GSSG) was reduced in young ovariectomized, old controls, and old ovariectomized groups when compared with young controls, indicating an increased oxidative stress. A negative correlation was found between GSH/GSSG and tumor necrosis factor-α (r=-0.6, P<0.003). Correlations were found between interleukin-6 with adipose tissue (r=0.5, P<0.009) and vagal tonus (r=-0.7, P<0.0002); and among myocardial performance index with interleukin-6 (r=0.65, P<0.0002), sympathetic tonus (r=0.55, P<0.006), and physical capacity (r=-0.55, P<0.003). The findings in this trial showed that ovariectomy aggravated the impairment of cardiac and functional effects of aging in female rats, probably associated with exacerbated autonomic dysfunction, inflammation, and oxidative stress. Keywords: autonomic nervous system, aging, aerobic exercise, female rats
format	article
author	Machi JF Dias DS Freitas SC Moraes OA da Silva MB Cruz PL Mostarda C Salemi VMC Morris M De Angelis K Irigoyen MC
author_facet	Machi JF Dias DS Freitas SC Moraes OA da Silva MB Cruz PL Mostarda C Salemi VMC Morris M De Angelis K Irigoyen MC
author_sort	Machi JF
title	Impact of aging on cardiac function in a female rat model of menopause: role of autonomic control, inflammation, and oxidative stress
title_short	Impact of aging on cardiac function in a female rat model of menopause: role of autonomic control, inflammation, and oxidative stress
title_full	Impact of aging on cardiac function in a female rat model of menopause: role of autonomic control, inflammation, and oxidative stress
title_fullStr	Impact of aging on cardiac function in a female rat model of menopause: role of autonomic control, inflammation, and oxidative stress
title_full_unstemmed	Impact of aging on cardiac function in a female rat model of menopause: role of autonomic control, inflammation, and oxidative stress
title_sort	impact of aging on cardiac function in a female rat model of menopause: role of autonomic control, inflammation, and oxidative stress
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/394ea01a003c4b728e47e67a7ad13063
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Impact of aging on cardiac function in a female rat model of menopause: role of autonomic control, inflammation, and oxidative stress

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