Validation of asynchronous quantitative bone densitometry of the spine: Accuracy, short-term reproducibility, and a comparison with conventional quantitative computed tomography

Abstract Asynchronous calibration quantitative computed tomography (QCT) is a new tool that allows the quantification of bone mineral density (BMD) without the use of a calibration phantom during scanning; however, this tool is not fully validated for clinical use. We used the European spine phantom...

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Autores principales:	Ling Wang, Yongbin Su, Qianqian Wang, Yangyang Duanmu, Minghui Yang, Chen Yi, Xiaoguang Cheng
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/395007e166ae4bddbbe145404d76847f
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spelling	oai:doaj.org-article:395007e166ae4bddbbe145404d76847f2021-12-02T15:06:22ZValidation of asynchronous quantitative bone densitometry of the spine: Accuracy, short-term reproducibility, and a comparison with conventional quantitative computed tomography10.1038/s41598-017-06608-y2045-2322https://doaj.org/article/395007e166ae4bddbbe145404d76847f2017-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-06608-yhttps://doaj.org/toc/2045-2322Abstract Asynchronous calibration quantitative computed tomography (QCT) is a new tool that allows the quantification of bone mineral density (BMD) without the use of a calibration phantom during scanning; however, this tool is not fully validated for clinical use. We used the European spine phantom (ESP) with repositioning during scanning and assessed the accuracy and short-term reproducibility of asynchronous QCT. Intra-scanner and intra-observer precision were each calculated as the root mean square of the standard deviation (RMSSD) and the coefficient of variation (CV-RMSSD). We also compared asynchronous and conventional QCT results in 50 clinical subjects. The accuracy of asynchronous QCT for three ESP vertebrae ranged from 1.4–6.7%, whereas intra-scanner precision for these vertebrae ranged from 0.53–0.91 mg/cc. Asynchronous QCT was most precise for a trabecular BMD of 100 mg/cc (CV-RMSSD = 0.2%). For intra-observer variability, overall precision error was smaller than 3%. In clinical subjects there was excellent agreement between the two calibration methods with correlation coefficients ranging from 0.96–0.99. A Bland–Altman analysis demonstrated that methodological differences depended on the magnitude of the BMD variable. Our findings indicate that the asynchronous QCT has good accuracy and precision for assessing trabecular BMD in the spine.Ling WangYongbin SuQianqian WangYangyang DuanmuMinghui YangChen YiXiaoguang ChengNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ling Wang Yongbin Su Qianqian Wang Yangyang Duanmu Minghui Yang Chen Yi Xiaoguang Cheng Validation of asynchronous quantitative bone densitometry of the spine: Accuracy, short-term reproducibility, and a comparison with conventional quantitative computed tomography
description	Abstract Asynchronous calibration quantitative computed tomography (QCT) is a new tool that allows the quantification of bone mineral density (BMD) without the use of a calibration phantom during scanning; however, this tool is not fully validated for clinical use. We used the European spine phantom (ESP) with repositioning during scanning and assessed the accuracy and short-term reproducibility of asynchronous QCT. Intra-scanner and intra-observer precision were each calculated as the root mean square of the standard deviation (RMSSD) and the coefficient of variation (CV-RMSSD). We also compared asynchronous and conventional QCT results in 50 clinical subjects. The accuracy of asynchronous QCT for three ESP vertebrae ranged from 1.4–6.7%, whereas intra-scanner precision for these vertebrae ranged from 0.53–0.91 mg/cc. Asynchronous QCT was most precise for a trabecular BMD of 100 mg/cc (CV-RMSSD = 0.2%). For intra-observer variability, overall precision error was smaller than 3%. In clinical subjects there was excellent agreement between the two calibration methods with correlation coefficients ranging from 0.96–0.99. A Bland–Altman analysis demonstrated that methodological differences depended on the magnitude of the BMD variable. Our findings indicate that the asynchronous QCT has good accuracy and precision for assessing trabecular BMD in the spine.
format	article
author	Ling Wang Yongbin Su Qianqian Wang Yangyang Duanmu Minghui Yang Chen Yi Xiaoguang Cheng
author_facet	Ling Wang Yongbin Su Qianqian Wang Yangyang Duanmu Minghui Yang Chen Yi Xiaoguang Cheng
author_sort	Ling Wang
title	Validation of asynchronous quantitative bone densitometry of the spine: Accuracy, short-term reproducibility, and a comparison with conventional quantitative computed tomography
title_short	Validation of asynchronous quantitative bone densitometry of the spine: Accuracy, short-term reproducibility, and a comparison with conventional quantitative computed tomography
title_full	Validation of asynchronous quantitative bone densitometry of the spine: Accuracy, short-term reproducibility, and a comparison with conventional quantitative computed tomography
title_fullStr	Validation of asynchronous quantitative bone densitometry of the spine: Accuracy, short-term reproducibility, and a comparison with conventional quantitative computed tomography
title_full_unstemmed	Validation of asynchronous quantitative bone densitometry of the spine: Accuracy, short-term reproducibility, and a comparison with conventional quantitative computed tomography
title_sort	validation of asynchronous quantitative bone densitometry of the spine: accuracy, short-term reproducibility, and a comparison with conventional quantitative computed tomography
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/395007e166ae4bddbbe145404d76847f
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Validation of asynchronous quantitative bone densitometry of the spine: Accuracy, short-term reproducibility, and a comparison with conventional quantitative computed tomography

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