Cord Blood Metabolome and BMI Trajectory from Birth to Adolescence: A Prospective Birth Cohort Study on Early Life Biomarkers of Persistent Obesity

There is increasing recognition on the role of early life metabolic programming in childhood obesity. This study sought to investigate whether newborn cord blood metabolome can predict future BMI. It included 946 children in the Boston Birth Cohort, a sample of high-risk yet understudied US urban, l...

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Autores principales:	Tingyi Cao, Jiaxuan Zhao, Xiumei Hong, Guoying Wang, Frank B. Hu, Xiaobin Wang, Liming Liang
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	metabolomics cord blood growth trajectory childhood obesity body mass index Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/39515e46be764cf2beb0b8be4eb0936e
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id	oai:doaj.org-article:39515e46be764cf2beb0b8be4eb0936e
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spelling	oai:doaj.org-article:39515e46be764cf2beb0b8be4eb0936e2021-11-25T18:20:34ZCord Blood Metabolome and BMI Trajectory from Birth to Adolescence: A Prospective Birth Cohort Study on Early Life Biomarkers of Persistent Obesity10.3390/metabo111107392218-1989https://doaj.org/article/39515e46be764cf2beb0b8be4eb0936e2021-10-01T00:00:00Zhttps://www.mdpi.com/2218-1989/11/11/739https://doaj.org/toc/2218-1989There is increasing recognition on the role of early life metabolic programming in childhood obesity. This study sought to investigate whether newborn cord blood metabolome can predict future BMI. It included 946 children in the Boston Birth Cohort, a sample of high-risk yet understudied US urban, low-income, predominantly Black and Hispanic children, who were enrolled at birth and followed prospectively up to age 18 years. A total of 376 metabolites were measured in cord blood plasma. Longitudinal BMI trajectories were defined and categorized into three distinct patterns: early onset overweight and obesity (early-OWO), late onset OWO (late-OWO), and normal weight trajectory (NW). Multinomial logistic regression models were used to identify metabolites individually or as network modules associated with BMI trajectories. Of the 946 children, 388, 254, and 304 were classified as early-OWO, late-OWO, and NW, respectively. Of the seven co-metabolomic network modules defined, two were inversely correlated with early-OWO. Among the 68 metabolites within the two modules, 22 triacylglycerols and diacylglycerols were negatively associated with early-OWO; 5 cholesterol esters were positively associated with early-OWO. In this prospective birth cohort, we demonstrated distinctive longitudinal BMI trajectories and identified multiple cord plasma metabolites in relevant biological pathways that were associated with early-OWO.Tingyi CaoJiaxuan ZhaoXiumei HongGuoying WangFrank B. HuXiaobin WangLiming LiangMDPI AGarticlemetabolomicscord bloodgrowth trajectorychildhood obesitybody mass indexMicrobiologyQR1-502ENMetabolites, Vol 11, Iss 739, p 739 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	metabolomics cord blood growth trajectory childhood obesity body mass index Microbiology QR1-502
spellingShingle	metabolomics cord blood growth trajectory childhood obesity body mass index Microbiology QR1-502 Tingyi Cao Jiaxuan Zhao Xiumei Hong Guoying Wang Frank B. Hu Xiaobin Wang Liming Liang Cord Blood Metabolome and BMI Trajectory from Birth to Adolescence: A Prospective Birth Cohort Study on Early Life Biomarkers of Persistent Obesity
description	There is increasing recognition on the role of early life metabolic programming in childhood obesity. This study sought to investigate whether newborn cord blood metabolome can predict future BMI. It included 946 children in the Boston Birth Cohort, a sample of high-risk yet understudied US urban, low-income, predominantly Black and Hispanic children, who were enrolled at birth and followed prospectively up to age 18 years. A total of 376 metabolites were measured in cord blood plasma. Longitudinal BMI trajectories were defined and categorized into three distinct patterns: early onset overweight and obesity (early-OWO), late onset OWO (late-OWO), and normal weight trajectory (NW). Multinomial logistic regression models were used to identify metabolites individually or as network modules associated with BMI trajectories. Of the 946 children, 388, 254, and 304 were classified as early-OWO, late-OWO, and NW, respectively. Of the seven co-metabolomic network modules defined, two were inversely correlated with early-OWO. Among the 68 metabolites within the two modules, 22 triacylglycerols and diacylglycerols were negatively associated with early-OWO; 5 cholesterol esters were positively associated with early-OWO. In this prospective birth cohort, we demonstrated distinctive longitudinal BMI trajectories and identified multiple cord plasma metabolites in relevant biological pathways that were associated with early-OWO.
format	article
author	Tingyi Cao Jiaxuan Zhao Xiumei Hong Guoying Wang Frank B. Hu Xiaobin Wang Liming Liang
author_facet	Tingyi Cao Jiaxuan Zhao Xiumei Hong Guoying Wang Frank B. Hu Xiaobin Wang Liming Liang
author_sort	Tingyi Cao
title	Cord Blood Metabolome and BMI Trajectory from Birth to Adolescence: A Prospective Birth Cohort Study on Early Life Biomarkers of Persistent Obesity
title_short	Cord Blood Metabolome and BMI Trajectory from Birth to Adolescence: A Prospective Birth Cohort Study on Early Life Biomarkers of Persistent Obesity
title_full	Cord Blood Metabolome and BMI Trajectory from Birth to Adolescence: A Prospective Birth Cohort Study on Early Life Biomarkers of Persistent Obesity
title_fullStr	Cord Blood Metabolome and BMI Trajectory from Birth to Adolescence: A Prospective Birth Cohort Study on Early Life Biomarkers of Persistent Obesity
title_full_unstemmed	Cord Blood Metabolome and BMI Trajectory from Birth to Adolescence: A Prospective Birth Cohort Study on Early Life Biomarkers of Persistent Obesity
title_sort	cord blood metabolome and bmi trajectory from birth to adolescence: a prospective birth cohort study on early life biomarkers of persistent obesity
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/39515e46be764cf2beb0b8be4eb0936e
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Cord Blood Metabolome and BMI Trajectory from Birth to Adolescence: A Prospective Birth Cohort Study on Early Life Biomarkers of Persistent Obesity

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