Inhibition of glycine transporter-1 in the dorsal vagal complex improves metabolic homeostasis in diabetes and obesity

Glycine sensing in the dorsal vagal complex (DVC) regulates hepatic glucose production in rodents. Here the authors show that pharmacological and molecular inhibition of glycine reuptake in the DVC potentiates NMDA receptors, and improves metabolic homeostasis in animal models of obesity and diabete...

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Autores principales:	Jessica T. Y. Yue, Mona A. Abraham, Paige V. Bauer, Mary P. LaPierre, Peili Wang, Frank A. Duca, Beatrice M. Filippi, Owen Chan, Tony K. T. Lam
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/39518d1b32d94bf387969a5e946ba9b7
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spelling	oai:doaj.org-article:39518d1b32d94bf387969a5e946ba9b72021-12-02T17:32:07ZInhibition of glycine transporter-1 in the dorsal vagal complex improves metabolic homeostasis in diabetes and obesity10.1038/ncomms135012041-1723https://doaj.org/article/39518d1b32d94bf387969a5e946ba9b72016-11-01T00:00:00Zhttps://doi.org/10.1038/ncomms13501https://doaj.org/toc/2041-1723Glycine sensing in the dorsal vagal complex (DVC) regulates hepatic glucose production in rodents. Here the authors show that pharmacological and molecular inhibition of glycine reuptake in the DVC potentiates NMDA receptors, and improves metabolic homeostasis in animal models of obesity and diabetes.Jessica T. Y. YueMona A. AbrahamPaige V. BauerMary P. LaPierrePeili WangFrank A. DucaBeatrice M. FilippiOwen ChanTony K. T. LamNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jessica T. Y. Yue Mona A. Abraham Paige V. Bauer Mary P. LaPierre Peili Wang Frank A. Duca Beatrice M. Filippi Owen Chan Tony K. T. Lam Inhibition of glycine transporter-1 in the dorsal vagal complex improves metabolic homeostasis in diabetes and obesity
description	Glycine sensing in the dorsal vagal complex (DVC) regulates hepatic glucose production in rodents. Here the authors show that pharmacological and molecular inhibition of glycine reuptake in the DVC potentiates NMDA receptors, and improves metabolic homeostasis in animal models of obesity and diabetes.
format	article
author	Jessica T. Y. Yue Mona A. Abraham Paige V. Bauer Mary P. LaPierre Peili Wang Frank A. Duca Beatrice M. Filippi Owen Chan Tony K. T. Lam
author_facet	Jessica T. Y. Yue Mona A. Abraham Paige V. Bauer Mary P. LaPierre Peili Wang Frank A. Duca Beatrice M. Filippi Owen Chan Tony K. T. Lam
author_sort	Jessica T. Y. Yue
title	Inhibition of glycine transporter-1 in the dorsal vagal complex improves metabolic homeostasis in diabetes and obesity
title_short	Inhibition of glycine transporter-1 in the dorsal vagal complex improves metabolic homeostasis in diabetes and obesity
title_full	Inhibition of glycine transporter-1 in the dorsal vagal complex improves metabolic homeostasis in diabetes and obesity
title_fullStr	Inhibition of glycine transporter-1 in the dorsal vagal complex improves metabolic homeostasis in diabetes and obesity
title_full_unstemmed	Inhibition of glycine transporter-1 in the dorsal vagal complex improves metabolic homeostasis in diabetes and obesity
title_sort	inhibition of glycine transporter-1 in the dorsal vagal complex improves metabolic homeostasis in diabetes and obesity
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/39518d1b32d94bf387969a5e946ba9b7
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Inhibition of glycine transporter-1 in the dorsal vagal complex improves metabolic homeostasis in diabetes and obesity

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