The deubiquitylating enzyme USP15 regulates homologous recombination repair and cancer cell response to PARP inhibitors

Deubiquitinases have been shown to be involved in double strand break repair pathways. Here the authors reveal that USP15 deybiquitinase plays a role in homologues recombination repair by targeting BARD1 and affecting cells response to PARP inhibitors.

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Autores principales:	Yihan Peng, Qingchao Liao, Wei Tan, Changmin Peng, Zhaohua Hu, Yali Chen, Zhuqing Li, Jing Li, Bei Zhen, Wenge Zhu, Xiangpan Li, Yi Yao, Qibin Song, Chengsheng Liu, Xiangdong Qi, Fuchu He, Huadong Pei
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3951c6375c58438dae1dcaab8823984a
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spelling	oai:doaj.org-article:3951c6375c58438dae1dcaab8823984a2021-12-02T17:01:48ZThe deubiquitylating enzyme USP15 regulates homologous recombination repair and cancer cell response to PARP inhibitors10.1038/s41467-019-09232-82041-1723https://doaj.org/article/3951c6375c58438dae1dcaab8823984a2019-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09232-8https://doaj.org/toc/2041-1723Deubiquitinases have been shown to be involved in double strand break repair pathways. Here the authors reveal that USP15 deybiquitinase plays a role in homologues recombination repair by targeting BARD1 and affecting cells response to PARP inhibitors.Yihan PengQingchao LiaoWei TanChangmin PengZhaohua HuYali ChenZhuqing LiJing LiBei ZhenWenge ZhuXiangpan LiYi YaoQibin SongChengsheng LiuXiangdong QiFuchu HeHuadong PeiNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yihan Peng Qingchao Liao Wei Tan Changmin Peng Zhaohua Hu Yali Chen Zhuqing Li Jing Li Bei Zhen Wenge Zhu Xiangpan Li Yi Yao Qibin Song Chengsheng Liu Xiangdong Qi Fuchu He Huadong Pei The deubiquitylating enzyme USP15 regulates homologous recombination repair and cancer cell response to PARP inhibitors
description	Deubiquitinases have been shown to be involved in double strand break repair pathways. Here the authors reveal that USP15 deybiquitinase plays a role in homologues recombination repair by targeting BARD1 and affecting cells response to PARP inhibitors.
format	article
author	Yihan Peng Qingchao Liao Wei Tan Changmin Peng Zhaohua Hu Yali Chen Zhuqing Li Jing Li Bei Zhen Wenge Zhu Xiangpan Li Yi Yao Qibin Song Chengsheng Liu Xiangdong Qi Fuchu He Huadong Pei
author_facet	Yihan Peng Qingchao Liao Wei Tan Changmin Peng Zhaohua Hu Yali Chen Zhuqing Li Jing Li Bei Zhen Wenge Zhu Xiangpan Li Yi Yao Qibin Song Chengsheng Liu Xiangdong Qi Fuchu He Huadong Pei
author_sort	Yihan Peng
title	The deubiquitylating enzyme USP15 regulates homologous recombination repair and cancer cell response to PARP inhibitors
title_short	The deubiquitylating enzyme USP15 regulates homologous recombination repair and cancer cell response to PARP inhibitors
title_full	The deubiquitylating enzyme USP15 regulates homologous recombination repair and cancer cell response to PARP inhibitors
title_fullStr	The deubiquitylating enzyme USP15 regulates homologous recombination repair and cancer cell response to PARP inhibitors
title_full_unstemmed	The deubiquitylating enzyme USP15 regulates homologous recombination repair and cancer cell response to PARP inhibitors
title_sort	deubiquitylating enzyme usp15 regulates homologous recombination repair and cancer cell response to parp inhibitors
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/3951c6375c58438dae1dcaab8823984a
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The deubiquitylating enzyme USP15 regulates homologous recombination repair and cancer cell response to PARP inhibitors

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