A genome-wide association study identifies risk loci to equine recurrent uveitis in German warmblood horses.
Equine recurrent uveitis (ERU) is a common eye disease affecting up to 3-15% of the horse population. A genome-wide association study (GWAS) using the Illumina equine SNP50 bead chip was performed to identify loci conferring risk to ERU. The sample included a total of 144 German warmblood horses. A...
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2013
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oai:doaj.org-article:3951fb5b22f04e77a249b003e0bd895c2021-11-18T08:59:35ZA genome-wide association study identifies risk loci to equine recurrent uveitis in German warmblood horses.1932-620310.1371/journal.pone.0071619https://doaj.org/article/3951fb5b22f04e77a249b003e0bd895c2013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23977091/?tool=EBIhttps://doaj.org/toc/1932-6203Equine recurrent uveitis (ERU) is a common eye disease affecting up to 3-15% of the horse population. A genome-wide association study (GWAS) using the Illumina equine SNP50 bead chip was performed to identify loci conferring risk to ERU. The sample included a total of 144 German warmblood horses. A GWAS showed a significant single nucleotide polymorphism (SNP) on horse chromosome (ECA) 20 at 49.3 Mb, with IL-17A and IL-17F being the closest genes. This locus explained a fraction of 23% of the phenotypic variance for ERU. A GWAS taking into account the severity of ERU, revealed a SNP on ECA18 nearby to the crystalline gene cluster CRYGA-CRYGF. For both genomic regions on ECA18 and 20, significantly associated haplotypes containing the genome-wide significant SNPs could be demonstrated. In conclusion, our results are indicative for a genetic component regulating the possible critical role of IL-17A and IL-17F in the pathogenesis of ERU. The associated SNP on ECA18 may be indicative for cataract formation in the course of ERU.Maike KulbrockStefanie LehnerJulia MetzgerBernhard OhnesorgeOttmar DistlPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 8, p e71619 (2013) |
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Medicine R Science Q Maike Kulbrock Stefanie Lehner Julia Metzger Bernhard Ohnesorge Ottmar Distl A genome-wide association study identifies risk loci to equine recurrent uveitis in German warmblood horses. |
| description |
Equine recurrent uveitis (ERU) is a common eye disease affecting up to 3-15% of the horse population. A genome-wide association study (GWAS) using the Illumina equine SNP50 bead chip was performed to identify loci conferring risk to ERU. The sample included a total of 144 German warmblood horses. A GWAS showed a significant single nucleotide polymorphism (SNP) on horse chromosome (ECA) 20 at 49.3 Mb, with IL-17A and IL-17F being the closest genes. This locus explained a fraction of 23% of the phenotypic variance for ERU. A GWAS taking into account the severity of ERU, revealed a SNP on ECA18 nearby to the crystalline gene cluster CRYGA-CRYGF. For both genomic regions on ECA18 and 20, significantly associated haplotypes containing the genome-wide significant SNPs could be demonstrated. In conclusion, our results are indicative for a genetic component regulating the possible critical role of IL-17A and IL-17F in the pathogenesis of ERU. The associated SNP on ECA18 may be indicative for cataract formation in the course of ERU. |
| format |
article |
| author |
Maike Kulbrock Stefanie Lehner Julia Metzger Bernhard Ohnesorge Ottmar Distl |
| author_facet |
Maike Kulbrock Stefanie Lehner Julia Metzger Bernhard Ohnesorge Ottmar Distl |
| author_sort |
Maike Kulbrock |
| title |
A genome-wide association study identifies risk loci to equine recurrent uveitis in German warmblood horses. |
| title_short |
A genome-wide association study identifies risk loci to equine recurrent uveitis in German warmblood horses. |
| title_full |
A genome-wide association study identifies risk loci to equine recurrent uveitis in German warmblood horses. |
| title_fullStr |
A genome-wide association study identifies risk loci to equine recurrent uveitis in German warmblood horses. |
| title_full_unstemmed |
A genome-wide association study identifies risk loci to equine recurrent uveitis in German warmblood horses. |
| title_sort |
genome-wide association study identifies risk loci to equine recurrent uveitis in german warmblood horses. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2013 |
| url |
https://doaj.org/article/3951fb5b22f04e77a249b003e0bd895c |
| work_keys_str_mv |
AT maikekulbrock agenomewideassociationstudyidentifiesrisklocitoequinerecurrentuveitisingermanwarmbloodhorses AT stefanielehner agenomewideassociationstudyidentifiesrisklocitoequinerecurrentuveitisingermanwarmbloodhorses AT juliametzger agenomewideassociationstudyidentifiesrisklocitoequinerecurrentuveitisingermanwarmbloodhorses AT bernhardohnesorge agenomewideassociationstudyidentifiesrisklocitoequinerecurrentuveitisingermanwarmbloodhorses AT ottmardistl agenomewideassociationstudyidentifiesrisklocitoequinerecurrentuveitisingermanwarmbloodhorses AT maikekulbrock genomewideassociationstudyidentifiesrisklocitoequinerecurrentuveitisingermanwarmbloodhorses AT stefanielehner genomewideassociationstudyidentifiesrisklocitoequinerecurrentuveitisingermanwarmbloodhorses AT juliametzger genomewideassociationstudyidentifiesrisklocitoequinerecurrentuveitisingermanwarmbloodhorses AT bernhardohnesorge genomewideassociationstudyidentifiesrisklocitoequinerecurrentuveitisingermanwarmbloodhorses AT ottmardistl genomewideassociationstudyidentifiesrisklocitoequinerecurrentuveitisingermanwarmbloodhorses |
| _version_ |
1718421074569330688 |