Impact of physiologically shaped pancreatic stent for chronic pancreatitis

Abstract Endoscopic pancreatic stenting is used to prevent main pancreatic duct obstruction and relieve painful symptoms of chronic pancreatitis. However, the stent typically needs to be exchanged and the rate of adverse events is high. Few studies have evaluated the effect of stent shape on those o...

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Autores principales:	Yasuki Hori, Yuka Ichino, Itaru Naitoh, Kazuki Hayashi, Michihiro Yoshida, Makoto Natsume, Naruomi Jinno, Akihisa Kato, Kenta Kachi, Go Asano, Naoki Atsuta, Hidenori Sahashi, Hiromi Kataoka, Hirotaka Ohara
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3952b8f322d64fc18c7fda2a9f33839d
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spelling	oai:doaj.org-article:3952b8f322d64fc18c7fda2a9f33839d2021-12-02T18:02:47ZImpact of physiologically shaped pancreatic stent for chronic pancreatitis10.1038/s41598-021-87852-12045-2322https://doaj.org/article/3952b8f322d64fc18c7fda2a9f33839d2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-87852-1https://doaj.org/toc/2045-2322Abstract Endoscopic pancreatic stenting is used to prevent main pancreatic duct obstruction and relieve painful symptoms of chronic pancreatitis. However, the stent typically needs to be exchanged and the rate of adverse events is high. Few studies have evaluated the effect of stent shape on those outcomes. We evaluated the adverse events, stent patency, and total medical cost within 90 days of patients who received an 8.5 French (Fr) physiologically shaped pancreatic stent by comparing these features with those associated with a conventional straight-type stent for ≥ 90 days. The total stent-related adverse event rate was significantly lower for the physiologically shaped pancreatic stent (physiologically shaped, 6.7% [2/30]; straight-type, 50.6% [44/87]; P < 0.001). Stent occlusion was significantly less frequent (P < 0.001) and the total medical costs were significantly lower (P = 0.002) for the physiologically shaped stent. The stent-related adverse event rate was significantly higher for the 10 Fr straight type stent than for the 8.5 Fr physiologically shaped stent (10 Fr, straight-type vs. 8.5 Fr, physiologically shaped: 36.1% [13/36] vs. 6.7% [2/30]; P = 0.007). In conclusion, a physiologically shaped pancreatic stent was superior to a straight-type stent in terms of the patency rate and medical costs.Yasuki HoriYuka IchinoItaru NaitohKazuki HayashiMichihiro YoshidaMakoto NatsumeNaruomi JinnoAkihisa KatoKenta KachiGo AsanoNaoki AtsutaHidenori SahashiHiromi KataokaHirotaka OharaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yasuki Hori Yuka Ichino Itaru Naitoh Kazuki Hayashi Michihiro Yoshida Makoto Natsume Naruomi Jinno Akihisa Kato Kenta Kachi Go Asano Naoki Atsuta Hidenori Sahashi Hiromi Kataoka Hirotaka Ohara Impact of physiologically shaped pancreatic stent for chronic pancreatitis
description	Abstract Endoscopic pancreatic stenting is used to prevent main pancreatic duct obstruction and relieve painful symptoms of chronic pancreatitis. However, the stent typically needs to be exchanged and the rate of adverse events is high. Few studies have evaluated the effect of stent shape on those outcomes. We evaluated the adverse events, stent patency, and total medical cost within 90 days of patients who received an 8.5 French (Fr) physiologically shaped pancreatic stent by comparing these features with those associated with a conventional straight-type stent for ≥ 90 days. The total stent-related adverse event rate was significantly lower for the physiologically shaped pancreatic stent (physiologically shaped, 6.7% [2/30]; straight-type, 50.6% [44/87]; P < 0.001). Stent occlusion was significantly less frequent (P < 0.001) and the total medical costs were significantly lower (P = 0.002) for the physiologically shaped stent. The stent-related adverse event rate was significantly higher for the 10 Fr straight type stent than for the 8.5 Fr physiologically shaped stent (10 Fr, straight-type vs. 8.5 Fr, physiologically shaped: 36.1% [13/36] vs. 6.7% [2/30]; P = 0.007). In conclusion, a physiologically shaped pancreatic stent was superior to a straight-type stent in terms of the patency rate and medical costs.
format	article
author	Yasuki Hori Yuka Ichino Itaru Naitoh Kazuki Hayashi Michihiro Yoshida Makoto Natsume Naruomi Jinno Akihisa Kato Kenta Kachi Go Asano Naoki Atsuta Hidenori Sahashi Hiromi Kataoka Hirotaka Ohara
author_facet	Yasuki Hori Yuka Ichino Itaru Naitoh Kazuki Hayashi Michihiro Yoshida Makoto Natsume Naruomi Jinno Akihisa Kato Kenta Kachi Go Asano Naoki Atsuta Hidenori Sahashi Hiromi Kataoka Hirotaka Ohara
author_sort	Yasuki Hori
title	Impact of physiologically shaped pancreatic stent for chronic pancreatitis
title_short	Impact of physiologically shaped pancreatic stent for chronic pancreatitis
title_full	Impact of physiologically shaped pancreatic stent for chronic pancreatitis
title_fullStr	Impact of physiologically shaped pancreatic stent for chronic pancreatitis
title_full_unstemmed	Impact of physiologically shaped pancreatic stent for chronic pancreatitis
title_sort	impact of physiologically shaped pancreatic stent for chronic pancreatitis
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3952b8f322d64fc18c7fda2a9f33839d
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Impact of physiologically shaped pancreatic stent for chronic pancreatitis

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