A novel mouse model demonstrates that oncogenic melanocyte stem cells engender melanoma resembling human disease

A novel mouse model demonstrates that oncogenic melanocyte stem cells engender melanoma resembling human disease

Currently, few mouse models exist to recapitulate human melanomagenesis. Here, the authors establish a c-Kit-CreER-driven model to target melanocyte stem cells (McSCs) and show that oncogenic McSCs give rise to epidermal melanoma that invade into the dermis, similar to human melanoma.

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Detalles Bibliográficos
Autores principales: Qi Sun, Wendy Lee, Yasuaki Mohri, Makoto Takeo, Chae Ho Lim, Xiaowei Xu, Peggy Myung, Radhika P. Atit, M. Mark Taketo, Rana S. Moubarak, Markus Schober, Iman Osman, Denise L. Gay, Dieter Saur, Emi K. Nishimura, Mayumi Ito
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/39566179028442d184f6030aa95f1bd5
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Descripción
Sumario:Currently, few mouse models exist to recapitulate human melanomagenesis. Here, the authors establish a c-Kit-CreER-driven model to target melanocyte stem cells (McSCs) and show that oncogenic McSCs give rise to epidermal melanoma that invade into the dermis, similar to human melanoma.

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