A novel mouse model demonstrates that oncogenic melanocyte stem cells engender melanoma resembling human disease
Currently, few mouse models exist to recapitulate human melanomagenesis. Here, the authors establish a c-Kit-CreER-driven model to target melanocyte stem cells (McSCs) and show that oncogenic McSCs give rise to epidermal melanoma that invade into the dermis, similar to human melanoma.
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2019
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/39566179028442d184f6030aa95f1bd5 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:39566179028442d184f6030aa95f1bd5 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:39566179028442d184f6030aa95f1bd52021-12-02T17:02:09ZA novel mouse model demonstrates that oncogenic melanocyte stem cells engender melanoma resembling human disease10.1038/s41467-019-12733-12041-1723https://doaj.org/article/39566179028442d184f6030aa95f1bd52019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12733-1https://doaj.org/toc/2041-1723Currently, few mouse models exist to recapitulate human melanomagenesis. Here, the authors establish a c-Kit-CreER-driven model to target melanocyte stem cells (McSCs) and show that oncogenic McSCs give rise to epidermal melanoma that invade into the dermis, similar to human melanoma.Qi SunWendy LeeYasuaki MohriMakoto TakeoChae Ho LimXiaowei XuPeggy MyungRadhika P. AtitM. Mark TaketoRana S. MoubarakMarkus SchoberIman OsmanDenise L. GayDieter SaurEmi K. NishimuraMayumi ItoNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Qi Sun Wendy Lee Yasuaki Mohri Makoto Takeo Chae Ho Lim Xiaowei Xu Peggy Myung Radhika P. Atit M. Mark Taketo Rana S. Moubarak Markus Schober Iman Osman Denise L. Gay Dieter Saur Emi K. Nishimura Mayumi Ito A novel mouse model demonstrates that oncogenic melanocyte stem cells engender melanoma resembling human disease |
| description |
Currently, few mouse models exist to recapitulate human melanomagenesis. Here, the authors establish a c-Kit-CreER-driven model to target melanocyte stem cells (McSCs) and show that oncogenic McSCs give rise to epidermal melanoma that invade into the dermis, similar to human melanoma. |
| format |
article |
| author |
Qi Sun Wendy Lee Yasuaki Mohri Makoto Takeo Chae Ho Lim Xiaowei Xu Peggy Myung Radhika P. Atit M. Mark Taketo Rana S. Moubarak Markus Schober Iman Osman Denise L. Gay Dieter Saur Emi K. Nishimura Mayumi Ito |
| author_facet |
Qi Sun Wendy Lee Yasuaki Mohri Makoto Takeo Chae Ho Lim Xiaowei Xu Peggy Myung Radhika P. Atit M. Mark Taketo Rana S. Moubarak Markus Schober Iman Osman Denise L. Gay Dieter Saur Emi K. Nishimura Mayumi Ito |
| author_sort |
Qi Sun |
| title |
A novel mouse model demonstrates that oncogenic melanocyte stem cells engender melanoma resembling human disease |
| title_short |
A novel mouse model demonstrates that oncogenic melanocyte stem cells engender melanoma resembling human disease |
| title_full |
A novel mouse model demonstrates that oncogenic melanocyte stem cells engender melanoma resembling human disease |
| title_fullStr |
A novel mouse model demonstrates that oncogenic melanocyte stem cells engender melanoma resembling human disease |
| title_full_unstemmed |
A novel mouse model demonstrates that oncogenic melanocyte stem cells engender melanoma resembling human disease |
| title_sort |
novel mouse model demonstrates that oncogenic melanocyte stem cells engender melanoma resembling human disease |
| publisher |
Nature Portfolio |
| publishDate |
2019 |
| url |
https://doaj.org/article/39566179028442d184f6030aa95f1bd5 |
| work_keys_str_mv |
AT qisun anovelmousemodeldemonstratesthatoncogenicmelanocytestemcellsengendermelanomaresemblinghumandisease AT wendylee anovelmousemodeldemonstratesthatoncogenicmelanocytestemcellsengendermelanomaresemblinghumandisease AT yasuakimohri anovelmousemodeldemonstratesthatoncogenicmelanocytestemcellsengendermelanomaresemblinghumandisease AT makototakeo anovelmousemodeldemonstratesthatoncogenicmelanocytestemcellsengendermelanomaresemblinghumandisease AT chaeholim anovelmousemodeldemonstratesthatoncogenicmelanocytestemcellsengendermelanomaresemblinghumandisease AT xiaoweixu anovelmousemodeldemonstratesthatoncogenicmelanocytestemcellsengendermelanomaresemblinghumandisease AT peggymyung anovelmousemodeldemonstratesthatoncogenicmelanocytestemcellsengendermelanomaresemblinghumandisease AT radhikapatit anovelmousemodeldemonstratesthatoncogenicmelanocytestemcellsengendermelanomaresemblinghumandisease AT mmarktaketo anovelmousemodeldemonstratesthatoncogenicmelanocytestemcellsengendermelanomaresemblinghumandisease AT ranasmoubarak anovelmousemodeldemonstratesthatoncogenicmelanocytestemcellsengendermelanomaresemblinghumandisease AT markusschober anovelmousemodeldemonstratesthatoncogenicmelanocytestemcellsengendermelanomaresemblinghumandisease AT imanosman anovelmousemodeldemonstratesthatoncogenicmelanocytestemcellsengendermelanomaresemblinghumandisease AT deniselgay anovelmousemodeldemonstratesthatoncogenicmelanocytestemcellsengendermelanomaresemblinghumandisease AT dietersaur anovelmousemodeldemonstratesthatoncogenicmelanocytestemcellsengendermelanomaresemblinghumandisease AT emiknishimura anovelmousemodeldemonstratesthatoncogenicmelanocytestemcellsengendermelanomaresemblinghumandisease AT mayumiito anovelmousemodeldemonstratesthatoncogenicmelanocytestemcellsengendermelanomaresemblinghumandisease AT qisun novelmousemodeldemonstratesthatoncogenicmelanocytestemcellsengendermelanomaresemblinghumandisease AT wendylee novelmousemodeldemonstratesthatoncogenicmelanocytestemcellsengendermelanomaresemblinghumandisease AT yasuakimohri novelmousemodeldemonstratesthatoncogenicmelanocytestemcellsengendermelanomaresemblinghumandisease AT makototakeo novelmousemodeldemonstratesthatoncogenicmelanocytestemcellsengendermelanomaresemblinghumandisease AT chaeholim novelmousemodeldemonstratesthatoncogenicmelanocytestemcellsengendermelanomaresemblinghumandisease AT xiaoweixu novelmousemodeldemonstratesthatoncogenicmelanocytestemcellsengendermelanomaresemblinghumandisease AT peggymyung novelmousemodeldemonstratesthatoncogenicmelanocytestemcellsengendermelanomaresemblinghumandisease AT radhikapatit novelmousemodeldemonstratesthatoncogenicmelanocytestemcellsengendermelanomaresemblinghumandisease AT mmarktaketo novelmousemodeldemonstratesthatoncogenicmelanocytestemcellsengendermelanomaresemblinghumandisease AT ranasmoubarak novelmousemodeldemonstratesthatoncogenicmelanocytestemcellsengendermelanomaresemblinghumandisease AT markusschober novelmousemodeldemonstratesthatoncogenicmelanocytestemcellsengendermelanomaresemblinghumandisease AT imanosman novelmousemodeldemonstratesthatoncogenicmelanocytestemcellsengendermelanomaresemblinghumandisease AT deniselgay novelmousemodeldemonstratesthatoncogenicmelanocytestemcellsengendermelanomaresemblinghumandisease AT dietersaur novelmousemodeldemonstratesthatoncogenicmelanocytestemcellsengendermelanomaresemblinghumandisease AT emiknishimura novelmousemodeldemonstratesthatoncogenicmelanocytestemcellsengendermelanomaresemblinghumandisease AT mayumiito novelmousemodeldemonstratesthatoncogenicmelanocytestemcellsengendermelanomaresemblinghumandisease |
| _version_ |
1718381959892172800 |