Targeting stromal remodeling and cancer stem cell plasticity overcomes chemoresistance in triple negative breast cancer

Targeting stromal remodeling and cancer stem cell plasticity overcomes chemoresistance in triple negative breast cancer

Stromal cell recruitment, activation and crosstalk with cancer cells is poorly understood. Here, the authors demonstrate that cancer cell-derived Hedgehog ligand  triggers stromal remodeling that in turn induces a cancer-stem-cell like, drug-resistant phenotype of nearby cancer cells while treatment...

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Autores principales: Aurélie S. Cazet, Mun N. Hui, Benjamin L. Elsworth, Sunny Z. Wu, Daniel Roden, Chia-Ling Chan, Joanna N. Skhinas, Raphaël Collot, Jessica Yang, Kate Harvey, M. Zahied Johan, Caroline Cooper, Radhika Nair, David Herrmann, Andrea McFarland, Niantao Deng, Manuel Ruiz-Borrego, Federico Rojo, José M. Trigo, Susana Bezares, Rosalía Caballero, Elgene Lim, Paul Timpson, Sandra O’Toole, D. Neil Watkins, Thomas R. Cox, Michael S. Samuel, Miguel Martín, Alexander Swarbrick
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/39594924f30743e1a45878b7f73d9070
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spelling oai:doaj.org-article:39594924f30743e1a45878b7f73d90702021-12-02T15:33:54ZTargeting stromal remodeling and cancer stem cell plasticity overcomes chemoresistance in triple negative breast cancer10.1038/s41467-018-05220-62041-1723https://doaj.org/article/39594924f30743e1a45878b7f73d90702018-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-05220-6https://doaj.org/toc/2041-1723Stromal cell recruitment, activation and crosstalk with cancer cells is poorly understood. Here, the authors demonstrate that cancer cell-derived Hedgehog ligand  triggers stromal remodeling that in turn induces a cancer-stem-cell like, drug-resistant phenotype of nearby cancer cells while treatment with smoothened inhibitors reverses these phenotypes.Aurélie S. CazetMun N. HuiBenjamin L. ElsworthSunny Z. WuDaniel RodenChia-Ling ChanJoanna N. SkhinasRaphaël CollotJessica YangKate HarveyM. Zahied JohanCaroline CooperRadhika NairDavid HerrmannAndrea McFarlandNiantao DengManuel Ruiz-BorregoFederico RojoJosé M. TrigoSusana BezaresRosalía CaballeroElgene LimPaul TimpsonSandra O’TooleD. Neil WatkinsThomas R. CoxMichael S. SamuelMiguel MartínAlexander SwarbrickNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-18 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Aurélie S. Cazet
Mun N. Hui
Benjamin L. Elsworth
Sunny Z. Wu
Daniel Roden
Chia-Ling Chan
Joanna N. Skhinas
Raphaël Collot
Jessica Yang
Kate Harvey
M. Zahied Johan
Caroline Cooper
Radhika Nair
David Herrmann
Andrea McFarland
Niantao Deng
Manuel Ruiz-Borrego
Federico Rojo
José M. Trigo
Susana Bezares
Rosalía Caballero
Elgene Lim
Paul Timpson
Sandra O’Toole
D. Neil Watkins
Thomas R. Cox
Michael S. Samuel
Miguel Martín
Alexander Swarbrick
Targeting stromal remodeling and cancer stem cell plasticity overcomes chemoresistance in triple negative breast cancer
description Stromal cell recruitment, activation and crosstalk with cancer cells is poorly understood. Here, the authors demonstrate that cancer cell-derived Hedgehog ligand  triggers stromal remodeling that in turn induces a cancer-stem-cell like, drug-resistant phenotype of nearby cancer cells while treatment with smoothened inhibitors reverses these phenotypes.
format article
author Aurélie S. Cazet
Mun N. Hui
Benjamin L. Elsworth
Sunny Z. Wu
Daniel Roden
Chia-Ling Chan
Joanna N. Skhinas
Raphaël Collot
Jessica Yang
Kate Harvey
M. Zahied Johan
Caroline Cooper
Radhika Nair
David Herrmann
Andrea McFarland
Niantao Deng
Manuel Ruiz-Borrego
Federico Rojo
José M. Trigo
Susana Bezares
Rosalía Caballero
Elgene Lim
Paul Timpson
Sandra O’Toole
D. Neil Watkins
Thomas R. Cox
Michael S. Samuel
Miguel Martín
Alexander Swarbrick
author_facet Aurélie S. Cazet
Mun N. Hui
Benjamin L. Elsworth
Sunny Z. Wu
Daniel Roden
Chia-Ling Chan
Joanna N. Skhinas
Raphaël Collot
Jessica Yang
Kate Harvey
M. Zahied Johan
Caroline Cooper
Radhika Nair
David Herrmann
Andrea McFarland
Niantao Deng
Manuel Ruiz-Borrego
Federico Rojo
José M. Trigo
Susana Bezares
Rosalía Caballero
Elgene Lim
Paul Timpson
Sandra O’Toole
D. Neil Watkins
Thomas R. Cox
Michael S. Samuel
Miguel Martín
Alexander Swarbrick
author_sort Aurélie S. Cazet
title Targeting stromal remodeling and cancer stem cell plasticity overcomes chemoresistance in triple negative breast cancer
title_short Targeting stromal remodeling and cancer stem cell plasticity overcomes chemoresistance in triple negative breast cancer
title_full Targeting stromal remodeling and cancer stem cell plasticity overcomes chemoresistance in triple negative breast cancer
title_fullStr Targeting stromal remodeling and cancer stem cell plasticity overcomes chemoresistance in triple negative breast cancer
title_full_unstemmed Targeting stromal remodeling and cancer stem cell plasticity overcomes chemoresistance in triple negative breast cancer
title_sort targeting stromal remodeling and cancer stem cell plasticity overcomes chemoresistance in triple negative breast cancer
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/39594924f30743e1a45878b7f73d9070
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