Structural insights on TRPV5 gating by endogenous modulators

Structural insights on TRPV5 gating by endogenous modulators

TRPV5 is a kidney specific transient receptor potential (TRP) channel with an important role in calcium reabsorption. Here the authors provide mechanistic insights into TRPV5 modulation by determining the phosphatidylinositol 4,5-bisphosphate and calmodulin bound TRPV5 cryo-EM structures.

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Detalles Bibliográficos
Autores principales: Taylor E. T. Hughes, Ruth A. Pumroy, Aysenur Torun Yazici, Marina A. Kasimova, Edwin C. Fluck, Kevin W. Huynh, Amrita Samanta, Sudheer K. Molugu, Z. Hong Zhou, Vincenzo Carnevale, Tibor Rohacs, Vera Y. Moiseenkova-Bell
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/395ce27b94e54cfa86305f1955b2fe21
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Descripción
Sumario:TRPV5 is a kidney specific transient receptor potential (TRP) channel with an important role in calcium reabsorption. Here the authors provide mechanistic insights into TRPV5 modulation by determining the phosphatidylinositol 4,5-bisphosphate and calmodulin bound TRPV5 cryo-EM structures.

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