Structural insights on TRPV5 gating by endogenous modulators

TRPV5 is a kidney specific transient receptor potential (TRP) channel with an important role in calcium reabsorption. Here the authors provide mechanistic insights into TRPV5 modulation by determining the phosphatidylinositol 4,5-bisphosphate and calmodulin bound TRPV5 cryo-EM structures.

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Autores principales:	Taylor E. T. Hughes, Ruth A. Pumroy, Aysenur Torun Yazici, Marina A. Kasimova, Edwin C. Fluck, Kevin W. Huynh, Amrita Samanta, Sudheer K. Molugu, Z. Hong Zhou, Vincenzo Carnevale, Tibor Rohacs, Vera Y. Moiseenkova-Bell
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/395ce27b94e54cfa86305f1955b2fe21
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spelling	oai:doaj.org-article:395ce27b94e54cfa86305f1955b2fe212021-12-02T16:56:53ZStructural insights on TRPV5 gating by endogenous modulators10.1038/s41467-018-06753-62041-1723https://doaj.org/article/395ce27b94e54cfa86305f1955b2fe212018-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06753-6https://doaj.org/toc/2041-1723TRPV5 is a kidney specific transient receptor potential (TRP) channel with an important role in calcium reabsorption. Here the authors provide mechanistic insights into TRPV5 modulation by determining the phosphatidylinositol 4,5-bisphosphate and calmodulin bound TRPV5 cryo-EM structures.Taylor E. T. HughesRuth A. PumroyAysenur Torun YaziciMarina A. KasimovaEdwin C. FluckKevin W. HuynhAmrita SamantaSudheer K. MoluguZ. Hong ZhouVincenzo CarnevaleTibor RohacsVera Y. Moiseenkova-BellNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Taylor E. T. Hughes Ruth A. Pumroy Aysenur Torun Yazici Marina A. Kasimova Edwin C. Fluck Kevin W. Huynh Amrita Samanta Sudheer K. Molugu Z. Hong Zhou Vincenzo Carnevale Tibor Rohacs Vera Y. Moiseenkova-Bell Structural insights on TRPV5 gating by endogenous modulators
description	TRPV5 is a kidney specific transient receptor potential (TRP) channel with an important role in calcium reabsorption. Here the authors provide mechanistic insights into TRPV5 modulation by determining the phosphatidylinositol 4,5-bisphosphate and calmodulin bound TRPV5 cryo-EM structures.
format	article
author	Taylor E. T. Hughes Ruth A. Pumroy Aysenur Torun Yazici Marina A. Kasimova Edwin C. Fluck Kevin W. Huynh Amrita Samanta Sudheer K. Molugu Z. Hong Zhou Vincenzo Carnevale Tibor Rohacs Vera Y. Moiseenkova-Bell
author_facet	Taylor E. T. Hughes Ruth A. Pumroy Aysenur Torun Yazici Marina A. Kasimova Edwin C. Fluck Kevin W. Huynh Amrita Samanta Sudheer K. Molugu Z. Hong Zhou Vincenzo Carnevale Tibor Rohacs Vera Y. Moiseenkova-Bell
author_sort	Taylor E. T. Hughes
title	Structural insights on TRPV5 gating by endogenous modulators
title_short	Structural insights on TRPV5 gating by endogenous modulators
title_full	Structural insights on TRPV5 gating by endogenous modulators
title_fullStr	Structural insights on TRPV5 gating by endogenous modulators
title_full_unstemmed	Structural insights on TRPV5 gating by endogenous modulators
title_sort	structural insights on trpv5 gating by endogenous modulators
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/395ce27b94e54cfa86305f1955b2fe21
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Structural insights on TRPV5 gating by endogenous modulators

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