Multidrug Resistance in <named-content content-type="genus-species">Neisseria gonorrhoeae</named-content>: Identification of Functionally Important Residues in the MtrD Efflux Protein

Multidrug Resistance in <named-content content-type="genus-species">Neisseria gonorrhoeae</named-content>: Identification of Functionally Important Residues in the MtrD Efflux Protein

ABSTRACT A key mechanism that Neisseria gonorrhoeae uses to achieve multidrug resistance is the expulsion of structurally different antimicrobials by the MtrD multidrug efflux protein. MtrD resembles the homologous Escherichia coli AcrB efflux protein with several common structural features, includi...

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Autores principales: Mohsen Chitsaz, Lauren Booth, Mitchell T. Blyth, Megan L. O’Mara, Melissa H. Brown
Formato: article
Lenguaje:EN
Publicado: American Society for Microbiology 2019
Materias:
Neisseria gonorrhoeae
multidrug resistance
efflux pumps
MtrCDE system
resistance-nodulation-division
molecular dynamics simulations
Microbiology
QR1-502
Acceso en línea:https://doaj.org/article/395e0dfab8694e24b390afe000859feb
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